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The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

Scientific reports, 2017-10, Vol.7 (1), p.13767-15, Article 13767

2017

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The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid

Nature communications, 2019-11, Vol.10 (1), p.5433-14, Article 5433

2019

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Comparison of mechanistic transport cycle models of ABC exporters

Biochimica et biophysica acta. Biomembranes, 2018-04, Vol.1860 (4), p.818-832

2018

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Investigating the Mechanism of Sodium Binding to SERT Using Direct Simulations

Frontiers in cellular neuroscience, 2021-05, Vol.15, p.673782-673782

2021

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Structural basis of organic cation transporter-3 inhibition

Nature communications, 2022-11, Vol.13 (1), p.6714-6714, Article 6714

2022

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An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel

Nature chemical biology, 2018-04, Vol.14 (4), p.396-404

2018

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Sodium Binding Stabilizes the Outward-Open State of SERT by Limiting Bundle Domain Motions

Cells (Basel, Switzerland), 2022-01, Vol.11 (2), p.255

2022

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Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter

Nature communications, 2017-01, Vol.8 (1), p.14089-14089, Article 14089

2017

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PIP2 modulates TRPC3 activity via TRP helix and S4-S5 linker

Nature communications, 2024-06, Vol.15 (1), p.5220-13

2024

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The Bile Salt Export Pump: Molecular Structure, Study Models and Small-Molecule Drugs for the Treatment of Inherited BSEP Deficiencies

International journal of molecular sciences, 2021-01, Vol.22 (2), p.784

2021

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Exploring TRPC3 Interaction with Cholesterol through Coarse-Grained Molecular Dynamics Simulations

Biomolecules (Basel, Switzerland), 2022-06, Vol.12 (7), p.890

2022

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Membrane-Mediated Effect on Ion Channels Induced by the Anesthetic Drug Ketamine

Journal of the American Chemical Society, 2010-06, Vol.132 (23), p.7990-7997

2010

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Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

Nature communications, 2024-01, Vol.15 (1), p.417-417, Article 417

2024

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A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain

Frontiers in physiology, 2023-04, Vol.14, p.1145973-1145973

2023

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Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion

PLoS genetics, 2020-10, Vol.16 (10), p.e1009016-e1009016

2020

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Mechanisms and significance of Ca2+ entry through TRPC channels

Current opinion in physiology, 2020-10, Vol.17, p.25-33

2020

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Analysis of Sequence Divergence in Mammalian ABCGs Predicts a Structural Network of Residues That Underlies Functional Divergence

International journal of molecular sciences, 2021-03, Vol.22 (6), p.3012

2021

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Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (28), p.11642-11647

2013

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Nucleotide binding is the critical regulator of ABCG2 conformational transitions

eLife, 2023-02, Vol.12

2023

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Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain

PLoS computational biology, 2018-06, Vol.14 (6), p.e1006229-e1006229

2018

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Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients

Molecular cancer therapeutics, 2014-07, Vol.13 (7), p.1777-1790

2014

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Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model

PLoS computational biology, 2013-02, Vol.9 (2), p.e1002909

2013

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Comparative oncology: ErbB-1 and ErbB-2 homologues in canine cancer are susceptible to cetuximab and trastuzumab targeting

Molecular immunology, 2012-04, Vol.50 (4), p.200-209

2012

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PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes

Proceedings of the National Academy of Sciences - PNAS, 2011-06, Vol.108 (26), p.10556-10561

2011

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Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux

Communications biology, 2022-11, Vol.5 (1), p.1259-11, Article 1259

2022

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The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid

Comparison of mechanistic transport cycle models of ABC exporters

Investigating the Mechanism of Sodium Binding to SERT Using Direct Simulations

Structural basis of organic cation transporter-3 inhibition

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel

Sodium Binding Stabilizes the Outward-Open State of SERT by Limiting Bundle Domain Motions

Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter

PIP2 modulates TRPC3 activity via TRP helix and S4-S5 linker

The Bile Salt Export Pump: Molecular Structure, Study Models and Small-Molecule Drugs for the Treatment of Inherited BSEP Deficiencies

Exploring TRPC3 Interaction with Cholesterol through Coarse-Grained Molecular Dynamics Simulations

Membrane-Mediated Effect on Ion Channels Induced by the Anesthetic Drug Ketamine

Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain

Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion

Mechanisms and significance of Ca2+ entry through TRPC channels

Analysis of Sequence Divergence in Mammalian ABCGs Predicts a Structural Network of Residues That Underlies Functional Divergence

Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate

Nucleotide binding is the critical regulator of ABCG2 conformational transitions

Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain

Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients

Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model

Comparative oncology: ErbB-1 and ErbB-2 homologues in canine cancer are susceptible to cetuximab and trastuzumab targeting

PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes

Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux

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