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Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes

Genome research, 2017-02, Vol.27 (2), p.208-222

2017

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Genomics of Islet (Dys)function and Type 2 Diabetes

Trends in genetics, 2017-04, Vol.33 (4), p.244-255

2017

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Regulation of the Oocyte-to-Zygote Transition

Science (American Association for the Advancement of Science), 2007-04, Vol.316 (5823), p.407-408

2007

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CoRE-ATAC: A deep learning model for the functional classification of regulatory elements from single cell and bulk ATAC-seq data

PLoS computational biology, 2021-12, Vol.17 (12), p.e1009670-e1009670

2021

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AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

Genome Biology, 2021-09, Vol.22 (1), p.252-252, Article 252

2021

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Single Cell Analysis of Blood Mononuclear Cells Stimulated Through Either LPS or Anti-CD3 and Anti-CD28

Frontiers in immunology, 2021-03, Vol.12, p.636720-636720

2021

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Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

Nature communications, 2021-09, Vol.12 (1), p.5242-5242, Article 5242

2021

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Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes

Nature communications, 2021-08, Vol.12 (1), p.5074-5074, Article 5074

2021

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A Common Functional Regulatory Variant at a Type 2 Diabetes Locus Upregulates ARAP1 Expression in the Pancreatic Beta Cell

American journal of human genetics, 2014-02, Vol.94 (2), p.186-197

2014

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(Epi)genomic heterogeneity of pancreatic islet function and failure in type 2 diabetes

Molecular metabolism (Germany), 2019-09, Vol.27 (Suppl), p.S15-S24

2019

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Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

Diabetes (New York, N.Y.), 2013-11, Vol.62 (11), p.3943-3950

2013

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A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus

Diabetes (New York, N.Y.), 2017-09, Vol.66 (9), p.2521-2530

2017

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"FunDNAmethyl" Mechanism for Developmental Restriction of a β-Cell Subpopulation

Diabetes (New York, N.Y.), 2023-05, Vol.72 (5), p.557-559

2023

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The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation

Current biology, 2006-01, Vol.16 (1), p.56-62

2006

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QuIN: A Web Server for Querying and Visualizing Chromatin Interaction Networks

PLoS computational biology, 2016-06, Vol.12 (6), p.e1004809-e1004809

2016

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2061-P: Islet Single Cell Transcriptomes Reveal Cellular and Gene Regulatory Alterations in Type 2 Diabetes Pathogenesis

Diabetes (New York, N.Y.), 2020-06, Vol.69 (Supplement_1)

2020

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Two-phase differential expression analysis for single cell RNA-seq

Bioinformatics, 2018-10, Vol.34 (19), p.3340-3348

2018

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Type 2 Diabetes-Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets

Diabetes (New York, N.Y.), 2018-11, Vol.67 (11), p.2466-2477

2018

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Regulation of MBK-2/Dyrk Kinase by Dynamic Cortical Anchoring during the Oocyte-to-Zygote Transition

Current biology, 2007-09, Vol.17 (18), p.1545-1554

2007

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The chromatin accessibility signature of human immune aging stems from CD8 + T cells

The Journal of experimental medicine, 2017-10, Vol.214 (10), p.3123-3144

2017

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A neural network based model effectively predicts enhancers from clinical ATAC-seq samples

Scientific reports, 2018-10, Vol.8 (1), p.16048-15, Article 16048

2018

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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (44), p.17921-17926

2013

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285-OR: Surveying Specific and Shared Responses of Human Islets to T2D-Associated Stressors

Diabetes (New York, N.Y.), 2023-06, Vol.72 (Supplement_1), p.1

2023

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Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts

Scientific reports, 2017-09, Vol.7 (1), p.11959-14, Article 11959

2017

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Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR–FlowFISH

Nature genetics, 2021-08, Vol.53 (8), p.1166-1176

2021

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Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes

Genomics of Islet (Dys)function and Type 2 Diabetes

Regulation of the Oocyte-to-Zygote Transition

CoRE-ATAC: A deep learning model for the functional classification of regulatory elements from single cell and bulk ATAC-seq data

AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

Single Cell Analysis of Blood Mononuclear Cells Stimulated Through Either LPS or Anti-CD3 and Anti-CD28

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes

A Common Functional Regulatory Variant at a Type 2 Diabetes Locus Upregulates ARAP1 Expression in the Pancreatic Beta Cell

(Epi)genomic heterogeneity of pancreatic islet function and failure in type 2 diabetes

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus

"FunDNAmethyl" Mechanism for Developmental Restriction of a β-Cell Subpopulation

The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation

QuIN: A Web Server for Querying and Visualizing Chromatin Interaction Networks

2061-P: Islet Single Cell Transcriptomes Reveal Cellular and Gene Regulatory Alterations in Type 2 Diabetes Pathogenesis

Two-phase differential expression analysis for single cell RNA-seq

Type 2 Diabetes-Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets

Regulation of MBK-2/Dyrk Kinase by Dynamic Cortical Anchoring during the Oocyte-to-Zygote Transition

The chromatin accessibility signature of human immune aging stems from CD8 + T cells

A neural network based model effectively predicts enhancers from clinical ATAC-seq samples

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

285-OR: Surveying Specific and Shared Responses of Human Islets to T2D-Associated Stressors

Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts

Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR–FlowFISH

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