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Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1

PloS one, 2017-08, Vol.12 (8), p.e0183563-e0183563

2017

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Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target

Amino acids, 2021-12, Vol.53 (12), p.1817-1834

2021

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A Hotspot for Disease-Associated Variants of Human PGM1 Is Associated with Impaired Ligand Binding and Loop Dynamics

Structure (London), 2018-10, Vol.26 (10), p.1337-1345.e3

2018

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Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono‑, Di‑, and Trifluorinated d‑Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition

ACS omega, 2019-04, Vol.4 (4), p.7029-7037

2019

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Structural and dynamical description of the enzymatic reaction of a phosphohexomutase

Structural dynamics (Melville, N.Y.), 2019-03, Vol.6 (2), p.024703-024703

2019

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The Metabolic Map into the Pathomechanism and Treatment of PGM1-CDG

American journal of human genetics, 2019-05, Vol.104 (5), p.835-846

2019

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Compromised Catalysis and Potential Folding Defects in in Vitro Studies of Missense Mutants Associated with Hereditary Phosphoglucomutase 1 Deficiency

The Journal of biological chemistry, 2014-11, Vol.289 (46), p.32010-32019

2014

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Trapping conformational states of a flavin-dependent N-monooxygenase in crystallo reveals protein and flavin dynamics

The Journal of biological chemistry, 2020-09, Vol.295 (38), p.13239-13249

2020

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Kinetics of human pyrroline-5-carboxylate reductase in l-thioproline metabolism

Amino acids, 2021-12, Vol.53 (12), p.1863-1874

2021

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Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily

Advances in protein chemistry and structural biology, 2017, Vol.109, p.265-304

2017

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Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans‐4‐hydroxy‐L‐proline

Protein science, 2021-08, Vol.30 (8), p.1714-1722

2021

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Phosphorylation-Dependent Effects on the Structural Flexibility of Phosphoglucosamine Mutase from Bacillus anthracis

ACS omega, 2017-11, Vol.2 (11), p.8445-8452

2017

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Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency

Journal of molecular biology, 2016-04, Vol.428 (8), p.1493-1505

2016

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Inhibitory Evaluation of αPMM/PGM from Pseudomonas aeruginosa: Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study

Journal of organic chemistry, 2019-08, Vol.84 (15), p.9627-9636

2019

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Cautionary Tale of Using Tris(alkyl)phosphine Reducing Agents with NAD+‑Dependent Enzymes

Biochemistry (Easton), 2020-09, Vol.59 (36), p.3285-3289

2020

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Effects of the T337M and G391V disease‐related variants on human phosphoglucomutase 1: structural disruptions large and small

Acta crystallographica. Section F, Structural biology communications, 2022-05, Vol.78 (5), p.200-209

2022

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Asp263 missense variants perturb the active site of human phosphoglucomutase 1

The FEBS journal, 2017-03, Vol.284 (6), p.937-947

2017

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Structure and characterization of a class 3B proline utilization A: Ligand-induced dimerization and importance of the C-terminal domain for catalysis

The Journal of biological chemistry, 2017-06, Vol.292 (23), p.9652-9665

2017

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A missense variant remote from the active site impairs stability of human phosphoglucomutase 1

Journal of inherited metabolic disease, 2020-07, Vol.43 (4), p.861-870

2020

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Synchrotron-based macromolecular crystallography module for an undergraduate biochemistry laboratory course

Journal of applied crystallography, 2016-12, Vol.49 (6), p.2235-2243

2016

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Assessment and Impacts of Phosphorylation on Protein Flexibility of the α-d-Phosphohexomutases

Methods in enzymology, 2018, Vol.607, p.241-267

2018

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Personalized biophysics of human PGM1 deficiency

Acta crystallographica. Section A, Foundations and advances, 2017-05, Vol.73 (a1), p.a167-a167

Stiers, Kyle M.

2017

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Use of polysterism analysis to probe the conformational landscape and residue networks within an α- D -phosphohexomutase

Acta crystallographica. Section A, Foundations and advances, 2018-07, Vol.74 (a1), p.a117-a117

2018

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Structural and dynamical description of the enzymatic reaction of a phosphohexomutase

Structural dynamics (Melville, N.Y.), 2019-04, Vol.6 (2)

2019

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Geriatric Rehabilitation Psychology

Practical Psychology in Medical Rehabilitation, p.181-187

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Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1

Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target

A Hotspot for Disease-Associated Variants of Human PGM1 Is Associated with Impaired Ligand Binding and Loop Dynamics

Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono‑, Di‑, and Trifluorinated d‑Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition

Structural and dynamical description of the enzymatic reaction of a phosphohexomutase

The Metabolic Map into the Pathomechanism and Treatment of PGM1-CDG

Compromised Catalysis and Potential Folding Defects in in Vitro Studies of Missense Mutants Associated with Hereditary Phosphoglucomutase 1 Deficiency

Trapping conformational states of a flavin-dependent N-monooxygenase in crystallo reveals protein and flavin dynamics

Kinetics of human pyrroline-5-carboxylate reductase in l-thioproline metabolism

Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily

Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans‐4‐hydroxy‐L‐proline

Phosphorylation-Dependent Effects on the Structural Flexibility of Phosphoglucosamine Mutase from Bacillus anthracis

Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency

Inhibitory Evaluation of αPMM/PGM from Pseudomonas aeruginosa: Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study

Cautionary Tale of Using Tris(alkyl)phosphine Reducing Agents with NAD+‑Dependent Enzymes

Effects of the T337M and G391V disease‐related variants on human phosphoglucomutase 1: structural disruptions large and small

Asp263 missense variants perturb the active site of human phosphoglucomutase 1

Structure and characterization of a class 3B proline utilization A: Ligand-induced dimerization and importance of the C-terminal domain for catalysis

A missense variant remote from the active site impairs stability of human phosphoglucomutase 1

Synchrotron-based macromolecular crystallography module for an undergraduate biochemistry laboratory course

Assessment and Impacts of Phosphorylation on Protein Flexibility of the α-d-Phosphohexomutases

Personalized biophysics of human PGM1 deficiency

Use of polysterism analysis to probe the conformational landscape and residue networks within an α- D -phosphohexomutase

Structural and dynamical description of the enzymatic reaction of a phosphohexomutase

Geriatric Rehabilitation Psychology

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