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Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

The Journal of cell biology, 2010-09, Vol.190 (5), p.911-925

2010

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Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons

PloS one, 2015-02, Vol.10 (2), p.e0117130-e0117130

2015

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Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Nature metabolism, 2019-11, Vol.1 (11), p.1110-1126

2019

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Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro

Journal of neurochemistry, 2005-12, Vol.95 (5), p.1373-1386

2005

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palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes

Journal of cell science, 2008-02, Vol.121 (4), p.437-449

2008

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Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex

Science (American Association for the Advancement of Science), 1998-11, Vol.282 (5393), p.1504-1508

1998

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The Role of the Synthetic Enzyme GAD65 in the Control of Neuronal γ -Aminobutyric Acid Release

Proceedings of the National Academy of Sciences - PNAS, 1999-10, Vol.96 (22), p.12911-12916

1999

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Increased Anxiety and Altered Responses to Anxiolytics in Mice Deficient in the 65-kDa Isoform of Glutamic Acid Decarboxylase

Proceedings of the National Academy of Sciences - PNAS, 1999-02, Vol.96 (4), p.1698-1703

1999

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Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters

Journal of cell science, 2004-04, Vol.117 (Pt 10), p.2001-2013

2004

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Epilepsy in Mice Deficient in the 65-kDa Isoform of Glutamic Acid Decarboxylase

Proceedings of the National Academy of Sciences - PNAS, 1997-12, Vol.94 (25), p.14060-14065

1997

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Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

Diabetes (New York, N.Y.), 2017-02, Vol.66 (2), p.460-473

2017

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Palmitoylation cycles and regulation of protein function (Review)

Molecular membrane biology, 2009, Vol.26 (1-2), p.42-54

2009

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Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice

Journal of autoimmunity, 2009-08, Vol.33 (1), p.50-57

2009

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A Combination of Three Distinct Trafficking Signals Mediates Axonal Targeting and Presynaptic Clustering of GAD65

The Journal of cell biology, 2002-09, Vol.158 (7), p.1229-1238

2002

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Bioengineering strategies for inducing tolerance in autoimmune diabetes

Advanced drug delivery reviews, 2017-05, Vol.114, p.256-265

2017

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Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

Nature (London), 1990-09, Vol.347 (6289), p.151-156

1990

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The Hydrophilic Isoform of Glutamate Decarboxylase, GAD67, Is Targeted to Membranes and Nerve Terminals Independent of Dimerization with the Hydrophobic Membrane-anchored Isoform, GAD65

The Journal of biological chemistry, 1999-12, Vol.274 (52), p.37200-37209

1999

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Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

Diabetes (New York, N.Y.), 2016-09, Vol.65 (9), p.2686-2699

2016

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Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Scientific reports, 2017-04, Vol.7 (1), p.45961-45961, Article 45961

2017

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Correction: Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Scientific reports, 2017-05, Vol.7 (1), Article 46801

2017

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Primary Human and Rat [Beta]-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

Diabetes (New York, N.Y.), 2017-02, Vol.66 (2), p.460

2017

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Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Scientific reports, 2017-05, Vol.7, p.46801-46801

2017

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Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

Nature (London), 1982-07, Vol.298 (5870), p.167-169

1982

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Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

Nature medicine, 1997-07, Vol.3 (7), p.738-743

1997

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Autoreactive Epitopes Defined by Diabetes-Associated Human Monoclonal Antibodies are Localized in the Middle and C-Terminal Domains of the Smaller Form of Glutamate Decarboxylase

Proceedings of the National Academy of Sciences - PNAS, 1993-04, Vol.90 (7), p.2832-2836

1993

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Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro

palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes

Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex

The Role of the Synthetic Enzyme GAD65 in the Control of Neuronal γ -Aminobutyric Acid Release

Increased Anxiety and Altered Responses to Anxiolytics in Mice Deficient in the 65-kDa Isoform of Glutamic Acid Decarboxylase

Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters

Epilepsy in Mice Deficient in the 65-kDa Isoform of Glutamic Acid Decarboxylase

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

Palmitoylation cycles and regulation of protein function (Review)

Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice

A Combination of Three Distinct Trafficking Signals Mediates Axonal Targeting and Presynaptic Clustering of GAD65

Bioengineering strategies for inducing tolerance in autoimmune diabetes

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

The Hydrophilic Isoform of Glutamate Decarboxylase, GAD67, Is Targeted to Membranes and Nerve Terminals Independent of Dimerization with the Hydrophobic Membrane-anchored Isoform, GAD65

Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Correction: Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Primary Human and Rat [Beta]-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

Autoreactive Epitopes Defined by Diabetes-Associated Human Monoclonal Antibodies are Localized in the Middle and C-Terminal Domains of the Smaller Form of Glutamate Decarboxylase

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