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brief perspective on insulin production

Diabetes, obesity & metabolism, 2009-11, Vol.11 (s4), p.189-196

2009

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Defective Prodynorphin Processing in Mice Lacking Prohormone Convertase PC2

Journal of neurochemistry, 2000-10, Vol.75 (4), p.1763-1770

2000

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Mortality in 7B2 Null Mice Can Be Rescued by Adrenalectomy: Involvement of Dopamine in ACTH Hypersecretion

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (5), p.3087-3092

2002

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The new enzymology of precursor processing endoproteases

The Journal of biological chemistry, 1992-11, Vol.267 (33), p.23435-23438

1992

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Proglucagon is Processed to Glucagon by Prohormone Convertase PC2 in αTC1-6 Cells

Proceedings of the National Academy of Sciences - PNAS, 1994-04, Vol.91 (8), p.3242-3246

1994

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Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6

Diabetes (New York, N.Y.), 1999-07, Vol.48 (7), p.1395-1401

1999

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Identification of cDNA Encoding a Second Putative Prohormone Convertase Related to PC2 in AtT20 Cells and Islets of Langerhans

Proceedings of the National Academy of Sciences - PNAS, 1991-01, Vol.88 (2), p.340-344

1991

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The proprotein convertases

Current opinion in chemical biology, 1998-02, Vol.2 (1), p.31-39

Steiner, Donald F

1998

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Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain

Journal of neurochemistry, 2004-04, Vol.89 (2), p.307-313

2004

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Developmental and tissue-regulated expression of IGF-I and IGF-II mRNAs in Sparus aurata

Journal of molecular endocrinology, 1996-04, Vol.16 (2), p.123-132

1996

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Kex2-Like Endoproteases PC2 and PC3 Accurately Cleave a Model Prohormone in Mammalian Cells: Evidence for a Common Core of Neuroendocrine Processing Enzymes

Proceedings of the National Academy of Sciences - PNAS, 1991-06, Vol.88 (12), p.5297-5301

1991

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Proteolytic Processing in the Secretory Pathway

The Journal of biological chemistry, 1999-07, Vol.274 (30), p.20745-20748

1999

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Disruption of PC1/3 Expression in Mice Causes Dwarfism and Multiple Neuroendocrine Peptide Processing Defects

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (16), p.10293-10298

2002

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Expression of Multiple Insulin and Insulin-Like Growth Factor Receptor Genes in Salmon Gill Cartilage

Proceedings of the National Academy of Sciences - PNAS, 1997-11, Vol.94 (23), p.12446-12451

1997

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An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing

The Journal of biological chemistry, 1988-11, Vol.263 (33), p.17243-17246

1988

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Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues : their use as markers of neuroendocrine differentiation

The journal of clinical endocrinology and metabolism, 1995, Vol.80 (1), p.294-301

1995

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Internal Cleavage of the Inhibitory 7B2 Carboxyl-Terminal Peptide by PC2: A Potential Mechanism for its Inactivation

Proceedings of the National Academy of Sciences - PNAS, 1996-05, Vol.93 (10), p.4919-4924

1996

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Evolution of the Insulin Superfamily: Cloning of a Hybrid Insulin/Insulin- Like Growth Factor cDNA from Amphioxus

Proceedings of the National Academy of Sciences - PNAS, 1990-12, Vol.87 (23), p.9319-9323

1990

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Severe Block in Processing of Proinsulin to Insulin Accompanied by Elevation of Des-64,65 Proinsulin Intermediates in Islets of Mice Lacking Prohormone Convertase 1/3

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (16), p.10299-10304

2002

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Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP

Molecular medicine (Cambridge, Mass.), 2000-12, Vol.6 (12), p.998-1007

2000

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Mutational Analysis of Invariant Valine B12 in Insulin: Implications for Receptor Binding

Biochemistry (Easton), 2000-12, Vol.39 (51), p.15826-15835

2000

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Nucleotide and Predicted Amino Acid Sequences of Cloned Human and Mouse Preprocathepsin B cDNAs

Proceedings of the National Academy of Sciences - PNAS, 1986-10, Vol.83 (20), p.7721-7725

1986

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Proinsulin Processing by the Subtilisin-Related Proprotein Convertases Furin, PC2, and PC3

Proceedings of the National Academy of Sciences - PNAS, 1992-09, Vol.89 (18), p.8822-8826

1992

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Lessons learned from molecular biology of insulin-gene mutations

Diabetes care, 1990-06, Vol.13 (6), p.600-609

1990

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Neuropeptide Processing Profile in Mice Lacking Prohormone Convertase-1

Biochemistry (Easton), 2005-03, Vol.44 (12), p.4939-4948

2005

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brief perspective on insulin production

Defective Prodynorphin Processing in Mice Lacking Prohormone Convertase PC2

Mortality in 7B2 Null Mice Can Be Rescued by Adrenalectomy: Involvement of Dopamine in ACTH Hypersecretion

The new enzymology of precursor processing endoproteases

Proglucagon is Processed to Glucagon by Prohormone Convertase PC2 in αTC1-6 Cells

Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6

Identification of cDNA Encoding a Second Putative Prohormone Convertase Related to PC2 in AtT20 Cells and Islets of Langerhans

The proprotein convertases

Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain

Developmental and tissue-regulated expression of IGF-I and IGF-II mRNAs in Sparus aurata

Kex2-Like Endoproteases PC2 and PC3 Accurately Cleave a Model Prohormone in Mammalian Cells: Evidence for a Common Core of Neuroendocrine Processing Enzymes

Proteolytic Processing in the Secretory Pathway

Disruption of PC1/3 Expression in Mice Causes Dwarfism and Multiple Neuroendocrine Peptide Processing Defects

Expression of Multiple Insulin and Insulin-Like Growth Factor Receptor Genes in Salmon Gill Cartilage

An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing

Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues : their use as markers of neuroendocrine differentiation

Internal Cleavage of the Inhibitory 7B2 Carboxyl-Terminal Peptide by PC2: A Potential Mechanism for its Inactivation

Evolution of the Insulin Superfamily: Cloning of a Hybrid Insulin/Insulin- Like Growth Factor cDNA from Amphioxus

Severe Block in Processing of Proinsulin to Insulin Accompanied by Elevation of Des-64,65 Proinsulin Intermediates in Islets of Mice Lacking Prohormone Convertase 1/3

Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP

Mutational Analysis of Invariant Valine B12 in Insulin: Implications for Receptor Binding

Nucleotide and Predicted Amino Acid Sequences of Cloned Human and Mouse Preprocathepsin B cDNAs

Proinsulin Processing by the Subtilisin-Related Proprotein Convertases Furin, PC2, and PC3

Lessons learned from molecular biology of insulin-gene mutations

Neuropeptide Processing Profile in Mice Lacking Prohormone Convertase-1

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