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Pharmacokinetic/pharmacodynamic modeling in drug development

Annual review of pharmacology and toxicology, 2000-01, Vol.40 (1), p.67-95

2000

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Good Practices in Model‐Informed Drug Discovery and Development: Practice, Application, and Documentation

CPT: pharmacometrics and systems pharmacology, 2016-03, Vol.5 (3), p.93-122

2016

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Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model

Journal of pharmacokinetics and pharmacodynamics, 2007-02, Vol.34 (1), p.57-85

2007

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Pharmacokinetic Similarity of Biologics: Analysis Using Nonlinear Mixed-Effects Modeling

Clinical pharmacology and therapeutics, 2012-02, Vol.91 (2), p.234-242

2012

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Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

Journal of Veterinary Pharmacology and Therapeutics, 2013-10, Vol.36 (5), p.417-419

2013

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Pharmacometrics: Opportunity for Reducing Disease Burden in the Developing World: The Case of Africa

CPT: pharmacometrics and systems pharmacology, 2013-08, Vol.2 (8), p.1-4

2013

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Modeling and Simulation to Optimize the Design and Analysis of Confirmatory Trials, Characterize Risk–Benefit, and Support Label Claims

CPT: pharmacometrics and systems pharmacology, 2013-02, Vol.2 (2), p.1-3

2013

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Population pharmacokinetics of ibandronate in Caucasian and Japanese healthy males and postmenopausal females

International journal of clinical pharmacology and therapeutics, 2006-12, Vol.44 (12), p.655

2006

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Pharmacometrics : modelling and simulation tools to improve decision making in clinical drug development

European journal of drug metabolism and pharmacokinetics, 2000-01, Vol.25 (1), p.49-58

2000

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Relationships between exposure to saquinavir monotherapy and antiviral response in HIV-positive patients

Clinical pharmacokinetics, 1999-07, Vol.37 (1), p.75-86

1999

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Role of modelling and simulation in Phase I drug development

European journal of pharmaceutical sciences, 2001-05, Vol.13 (2), p.115-122

2001

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Population pharmacokinetic analysis of the major metabolites of capecitabine

Journal of pharmacokinetics and pharmacodynamics, 2002-02, Vol.29 (1), p.25-47

2002

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The use of population pharmacokinetics in drug development

Clinical pharmacokinetics, 1996-02, Vol.30 (2), p.81-93

1996

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An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development experience within Hoffmann La Roche

Clinical pharmacokinetics, 1997-08, Vol.33 (2), p.142-152

1997

Volltextzugriff (PDF)

Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone

Clinical pharmacology and therapeutics, 2000-06, Vol.67 (6), p.610-620

2000

Volltextzugriff (PDF)

Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling

International journal of clinical pharmacology and therapeutics, 1997-10, Vol.35 (10), p.469

1997

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Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

European journal of clinical pharmacology, 1996, Vol.49 (4), p.251-254

1996

Volltextzugriff (PDF)

Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies

British journal of clinical pharmacology, 2000-01, Vol.49 (1), p.39-48

2000

Volltextzugriff (PDF)

Sparse sampling for assessment of drug exposure in toxicological studies

European journal of drug metabolism and pharmacokinetics, 1996-04, Vol.21 (2), p.105-111

1996

Volltextzugriff (PDF)

Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software

European journal of clinical pharmacology, 1994-06, Vol.46 (5), p.389-391

1994

Volltextzugriff (PDF)

Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Journal of pharmaceutical sciences, 1991-01, Vol.80 (1), p.3-10

1991

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Pharmacokinetic and pharmacodynamic data and models in clinical trials

European journal of drug metabolism and pharmacokinetics, 1993-01, Vol.18 (1), p.61-76

1993

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Zero-order absorption and linear disposition of oral colchicine in healthy volunteers

European journal of clinical pharmacology, 1989, Vol.37 (1), p.79-84

1989

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Exploratory analysis of population pharmacokinetic data from clinical trials with application to isradipine

Clinical pharmacology and therapeutics, 1991-07, Vol.50 (1), p.39-54

1991

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Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application

Clinical pharmacokinetics, 1985-01, Vol.10 (6), p.457-476

1985

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Pharmacokinetic/pharmacodynamic modeling in drug development

Good Practices in Model‐Informed Drug Discovery and Development: Practice, Application, and Documentation

Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model

Pharmacokinetic Similarity of Biologics: Analysis Using Nonlinear Mixed-Effects Modeling

Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

Pharmacometrics: Opportunity for Reducing Disease Burden in the Developing World: The Case of Africa

Modeling and Simulation to Optimize the Design and Analysis of Confirmatory Trials, Characterize Risk–Benefit, and Support Label Claims

Population pharmacokinetics of ibandronate in Caucasian and Japanese healthy males and postmenopausal females

Pharmacometrics : modelling and simulation tools to improve decision making in clinical drug development

Relationships between exposure to saquinavir monotherapy and antiviral response in HIV-positive patients

Role of modelling and simulation in Phase I drug development

Population pharmacokinetic analysis of the major metabolites of capecitabine

The use of population pharmacokinetics in drug development

An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development experience within Hoffmann La Roche

Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone

Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling

Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies

Sparse sampling for assessment of drug exposure in toxicological studies

Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software

Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Pharmacokinetic and pharmacodynamic data and models in clinical trials

Zero-order absorption and linear disposition of oral colchicine in healthy volunteers

Exploratory analysis of population pharmacokinetic data from clinical trials with application to isradipine

Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application

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