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Signal transduction mediated by the Ras Raf MEK ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

Leukemia, 2003-07, Vol.17 (7), p.1263-1293

2003

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Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

Leukemia, 2009-01, Vol.23 (1), p.25-42

2009

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JAK STAT, Raf MEK ERK, PI3K Akt and BCR-ABL in cell cycle progression and leukemogenesis

Leukemia, 2004-02, Vol.18 (2), p.189-218

2004

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Involvement of PI3K Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

Leukemia, 2003-03, Vol.17 (3), p.590-603

2003

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Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells

Cancer research (Chicago, Ill.), 2004-11, Vol.64 (22), p.8397-8404

2004

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Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review)

International journal of oncology, 2003-03, Vol.22 (3), p.469

2003

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Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

Leukemia, 1998-12, Vol.12 (12), p.1903-1929

1998

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Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells

Cell cycle (Georgetown, Tex.), 2004-03, Vol.3 (3), p.372-379

2004

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The complexity of PTEN: mutation, marker and potential target for therapeutic intervention

Expert opinion on therapeutic targets, 2004-12, Vol.8 (6), p.537-550

2004

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Raf-1 and Bcl-2 Induce Distinct and Common Pathways That Contribute to Breast Cancer Drug Resistance

Clinical cancer research, 2003-03, Vol.9 (3), p.1161-1170

2003

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Effects of the RAF MEK ERK and PI3K AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells

Oncogene, 2003-04, Vol.22 (16), p.2478-2492

2003

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Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells : possible sites for intervention with anti-neoplastic drugs

Leukemia, 1999-08, Vol.13 (8), p.1109-1166

1999

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The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors

Pharmacology & therapeutics (Oxford), 2000-12, Vol.88 (3), p.229-279

2000

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Role of the Raf Signal Transduction Cascade in the in Vitro Resistance to the Anticancer Drug Doxorubicin

Clinical cancer research, 2001-09, Vol.7 (9), p.2898-2907

2001

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The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?

Expert opinion on therapeutic targets, 2005-10, Vol.9 (5), p.1009-1030

2005

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Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation

Leukemia, 2003-09, Vol.17 (9), p.1765-1782

2003

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Emerging Raf inhibitors

Expert opinion on emerging drugs, 2009-12, Vol.14 (4), p.633-648

2009

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Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells

International journal of oncology, 2005-06, Vol.26 (6), p.1637

2005

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Requirement for the PI3K Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia

Leukemia, 2003-06, Vol.17 (6), p.1058-1067

2003

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Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

Leukemia, 2000-04, Vol.14 (4), p.642-656

2000

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A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells

Oncogene, 2000-01, Vol.19 (4), p.526-536

2000

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Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells

Cell cycle (Georgetown, Tex.), 2004-04, Vol.3 (4), p.503-512

2004

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Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells

Oncogene, 2004-10, Vol.23 (47), p.7810-7820

2004

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Conditional EGFR Promotes Cell Cycle Progression and Prevention of Apoptosis in the Absence of Autocrine Cytokines

Cell cycle (Georgetown, Tex.), 2005-06, Vol.4 (6), p.822-830

2005

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Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells

Leukemia, 2000-06, Vol.14 (6), p.1080-1096

2000

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Signal transduction mediated by the Ras Raf MEK ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

JAK STAT, Raf MEK ERK, PI3K Akt and BCR-ABL in cell cycle progression and leukemogenesis

Involvement of PI3K Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review)

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells

The complexity of PTEN: mutation, marker and potential target for therapeutic intervention

Raf-1 and Bcl-2 Induce Distinct and Common Pathways That Contribute to Breast Cancer Drug Resistance

Effects of the RAF MEK ERK and PI3K AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells : possible sites for intervention with anti-neoplastic drugs

The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors

Role of the Raf Signal Transduction Cascade in the in Vitro Resistance to the Anticancer Drug Doxorubicin

The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?

Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation

Emerging Raf inhibitors

Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells

Requirement for the PI3K Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells

Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells

Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells

Conditional EGFR Promotes Cell Cycle Progression and Prevention of Apoptosis in the Absence of Autocrine Cytokines

Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells

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