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Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4288-4305

2009

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SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

Blood, 2009-01, Vol.113 (4), p.846-855

2009

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Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity

The Journal of pharmacology and experimental therapeutics, 2010-03, Vol.332 (3), p.849-857

2010

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Dominant-Negative Inhibitors of Soluble TNF Attenuate Experimental Arthritis without Suppressing Innate Immunity to Infection

Journal of Immunology, 2007-08, Vol.179 (3), p.1872-1883

2007

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SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase–Dependent Cancers

Clinical cancer research, 2008-01, Vol.14 (1), p.240-248

2008

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Optimization of Halopemide for Phospholipase D2 inhibition

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (8), p.2310-2311

2007

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Presence of Cathepsin B in the Human Pancreatic Secretory Pathway and Its Role in Trypsinogen Activation during Hereditary Pancreatitis

The Journal of biological chemistry, 2002-06, Vol.277 (24), p.21389-21396

2002

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Inactivation of TNF Signaling by Rationally Designed Dominant-Negative TNF Variants

Science (American Association for the Advancement of Science), 2003-09, Vol.301 (5641), p.1895-1898

2003

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Characterization of human PLD2 and the analysis of PLD isoform splice variants

The FASEB journal, 1998-10, Vol.12 (13), p.1309-1317

1998

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Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (7), p.2550-2554

2012

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Discovery of Highly Selective Inhibitors of p38α

Current topics in medicinal chemistry, 2005-09, Vol.5 (10), p.941-951

2005

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Phospholipase D Regulation by a Physical Interaction with the Actin-Binding Protein Gelsolin

Biochemistry (Easton), 1996-04, Vol.35 (16), p.5229-5237

1996

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The TNF superfamily is on the TRAIL to BlyS

Drug discovery today, 2003-02, Vol.8 (3), p.114-117

2003

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When Less is More: Enhanced Baculovirus Production of Recombinant Proteins at Very Low Multiplicities of Infection

BioTechniques, 1999-01, Vol.26 (1), p.36-42

1999

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Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

Arthritis and rheumatism, 2008-12, Vol.58 (12), p.3765-3775

2008

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PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development

Journal of Immunology, 2006-06, Vol.176 (12), p.7525-7532

2006

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Use of the rep technique for allele replacement to construct mutants with deletions of the pstSCAB-phoU operon: evidence of a new role for the PhoU protein in the phosphate regulon

Journal of Bacteriology, 1993-11, Vol.175 (21), p.6797-6809

1993

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Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib

Oncology research, 2009-01, Vol.18 (5-6), p.229-242

2009

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Discovery of highly selective inhibitors of p38alpha

Current topics in medicinal chemistry, 2005, Vol.5 (10), p.941

2005

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Characterization of recombinant human cathepsin B expressed at high levels in baculovirus

Protein science, 1998-09, Vol.7 (9), p.2033-2037

1998

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Joke-Making Jews, Jokes Making Jews: Humor and Identity in Abraham Cahan’s Yekl

Journal of the short story in English, 2004, p.45-57

Steed, Jason Paul

2004

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Computerized indexing of reprints and bound articles

Journal of chemical education, 1971-06, Vol.48 (6), p.375

Steed, S. Paul

1971

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No pain, no gain: Implementing new art technology in Quake 3: Arena

Game Developer, 1999-12, Vol.6 (12), p.31

Steed, Paul

1999

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Mo-cap and keyframing, sittin' in a tree

Game Developer, 1999-11, Vol.6 (11), p.19

Steed, Paul

1999

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Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity

Dominant-Negative Inhibitors of Soluble TNF Attenuate Experimental Arthritis without Suppressing Innate Immunity to Infection

SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase–Dependent Cancers

Optimization of Halopemide for Phospholipase D2 inhibition

Presence of Cathepsin B in the Human Pancreatic Secretory Pathway and Its Role in Trypsinogen Activation during Hereditary Pancreatitis

Inactivation of TNF Signaling by Rationally Designed Dominant-Negative TNF Variants

Characterization of human PLD2 and the analysis of PLD isoform splice variants

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90

Discovery of Highly Selective Inhibitors of p38α

Phospholipase D Regulation by a Physical Interaction with the Actin-Binding Protein Gelsolin

The TNF superfamily is on the TRAIL to BlyS

When Less is More: Enhanced Baculovirus Production of Recombinant Proteins at Very Low Multiplicities of Infection

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development

Use of the rep technique for allele replacement to construct mutants with deletions of the pstSCAB-phoU operon: evidence of a new role for the PhoU protein in the phosphate regulon

Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib

Discovery of highly selective inhibitors of p38alpha

Characterization of recombinant human cathepsin B expressed at high levels in baculovirus

Joke-Making Jews, Jokes Making Jews: Humor and Identity in Abraham Cahan’s Yekl

Computerized indexing of reprints and bound articles

No pain, no gain: Implementing new art technology in Quake 3: Arena

Mo-cap and keyframing, sittin' in a tree

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