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"Cytokine Storm" in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics

Journal of Immunology, 2007-09, Vol.179 (5), p.3325-3331

2007

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SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19)

Frontiers in immunology, 2022-04, Vol.13, p.836492

2022

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Characterization of a novel potency endpoint for the evaluation of immune checkpoint blockade in humanized mice

Frontiers in immunology, 2023-03, Vol.14, p.1107848-1107848

2023

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Immunogenicity of a recombinant measles-HIV-1 clade B candidate vaccine

PloS one, 2012-11, Vol.7 (11), p.e50397-e50397

2012

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Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412

Journal of immunological methods, 2010-01, Vol.352 (1), p.1-12

2010

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Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine

PLoS pathogens, 2016-12, Vol.12 (12), p.e1006083-e1006083

2016

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Allogeneic lymphocyte transfer in MHC-identical siblings and MHC-identical unrelated Mauritian cynomolgus macaques

PloS one, 2014-02, Vol.9 (2), p.e88670-e88670

2014

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How predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response

Cytokine (Philadelphia, Pa.), 2013-10, Vol.64 (1), p.471-472

2013

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Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues

PloS one, 2014-08, Vol.9 (8), p.e104390

2014

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AZD1222 (ChAdOx1 nCov-19): A Single-Dose biodistribution study in mice

Vaccine, 2022-01, Vol.40 (2), p.192-195

2022

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Early potent protection against heterologous SIVsmE660 challenge following live attenuated SIV vaccination in Mauritian cynomolgus macaques

PloS one, 2011-08, Vol.6 (8), p.e23092-e23092

2011

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Developmental and reproductive safety of AZD1222 (ChAdOx1 nCoV-19) in mice

Reproductive toxicology (Elmsford, N.Y.), 2021-09, Vol.104, p.134-142

2021

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Occult replication of a conditionally-live attenuated SIV profoundly upregulates T effector memory cell frequency

Retrovirology, 2011-10, Vol.8 (S2), p.O41-O41, Article O41

2011

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Safety of biologics, lessons learnt from TGN1412

Current opinion in biotechnology, 2009-12, Vol.20 (6), p.673-677

2009

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CD8+ Lymphocytes Do Not Mediate Protection against Acute Superinfection 20 Days after Vaccination with a Live Attenuated Simian Immunodeficiency Virus

Journal of Virology, 2005-10, Vol.79 (19), p.12264-12272

2005

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Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

Retrovirology, 2012-07, Vol.9 (1), p.56-56, Article 56

2012

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Vaccination with live attenuated simian immunodeficiency virus causes dynamic changes in intestinal CD4+CCR5+ T cells

Retrovirology, 2011-02, Vol.8 (1), p.8-8, Article 8

2011

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Su1770 AZD7798: A NEW CCR9 DEPLETING ANTIBODY TO TREAT CROHN'S DISEASE

Gastroenterology (New York, N.Y. 1943), 2023-05, Vol.164 (6), p.S-674-S-674

2023

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Higher mass meningococcal group C-tetanus toxoid vaccines conjugated with carbodiimide correlate with greater immunogenicity

Vaccine, 2020-03, Vol.38 (13), p.2859-2869

2020

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Recent Advancements and Applications of Human Immune System Mice in Preclinical Immuno-Oncology

Toxicologic Pathology, 2020-02, Vol.48 (2), p.302-316

2020

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Severity of the TGN1412 trial disaster cytokine storm correlated with IL‐2 release

British journal of clinical pharmacology, 2013-08, Vol.76 (2), p.299-315

2013

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Replication kinetics and persistence of a conditionally live attenuated SIV (SIVrtTA) in vivo confers protection against SIVmac239 wild-type challenge in a rhesus macaque model

Retrovirology, 2009-09, Vol.6 (Suppl 2), p.P13-P13, Article P13

2009

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Live attenuated simian immunodeficiency virus vaccination confers superinfection resistance against macrophage-tropic and neurovirulent wild-type SIV challenge

Journal of general virology, 2015-07, Vol.96 (Pt 7), p.1918-1929

2015

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Cytokine release assays post TGN1412

Toxicology letters, 2014-09, Vol.229, p.S8-S9

2014

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"Cytokine Storm" in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics

SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19)

Characterization of a novel potency endpoint for the evaluation of immune checkpoint blockade in humanized mice

Immunogenicity of a recombinant measles-HIV-1 clade B candidate vaccine

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412

Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine

Allogeneic lymphocyte transfer in MHC-identical siblings and MHC-identical unrelated Mauritian cynomolgus macaques

How predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response

Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues

AZD1222 (ChAdOx1 nCov-19): A Single-Dose biodistribution study in mice

Early potent protection against heterologous SIVsmE660 challenge following live attenuated SIV vaccination in Mauritian cynomolgus macaques

Developmental and reproductive safety of AZD1222 (ChAdOx1 nCoV-19) in mice

Occult replication of a conditionally-live attenuated SIV profoundly upregulates T effector memory cell frequency

Safety of biologics, lessons learnt from TGN1412

CD8+ Lymphocytes Do Not Mediate Protection against Acute Superinfection 20 Days after Vaccination with a Live Attenuated Simian Immunodeficiency Virus

Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model

Vaccination with live attenuated simian immunodeficiency virus causes dynamic changes in intestinal CD4+CCR5+ T cells

Su1770 AZD7798: A NEW CCR9 DEPLETING ANTIBODY TO TREAT CROHN'S DISEASE

Higher mass meningococcal group C-tetanus toxoid vaccines conjugated with carbodiimide correlate with greater immunogenicity

Recent Advancements and Applications of Human Immune System Mice in Preclinical Immuno-Oncology

Severity of the TGN1412 trial disaster cytokine storm correlated with IL‐2 release

Replication kinetics and persistence of a conditionally live attenuated SIV (SIVrtTA) in vivo confers protection against SIVmac239 wild-type challenge in a rhesus macaque model

Live attenuated simian immunodeficiency virus vaccination confers superinfection resistance against macrophage-tropic and neurovirulent wild-type SIV challenge

Cytokine release assays post TGN1412

Vaccination of Macaques with DNA Followed by Adenoviral Vectors Encoding Simian Immunodeficiency Virus (SIV) Gag Alone Delays Infection by Repeated Mucosal Challenge with SIV

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