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Pharmacokinetics and Pharmacodynamics of Intravenously Administered Anesthetic Drugs: Concepts and Lessons for Drug Development

Clinical pharmacology and therapeutics, 2008-07, Vol.84 (1), p.153-157

2008

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The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

Anesthesiology (Philadelphia), 1993-11, Vol.79 (5), p.881-892

1993

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Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling

British journal of pharmacology, 2014-11, Vol.171 (22), p.5076-5092

2014

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A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

Clinical pharmacology and therapeutics, 1997-01, Vol.61 (1), p.45-58

1997

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Linearity of pharmacokinetics and model estimation of sufentanil

Anesthesiology (Philadelphia), 1995-12, Vol.83 (6), p.1194-1204

1995

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Characterization and validation of a pharmacokinetic model for controlled‐release oxycodone

British journal of clinical pharmacology, 1996-12, Vol.42 (6), p.747-756

1996

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Absorption characteristics of transdermally administered fentanyl

Anesthesiology (Philadelphia), 1989-06, Vol.70 (6), p.928-934

1989

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PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats

British journal of pharmacology, 2013-08, Vol.169 (7), p.1510-1524

2013

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Individualized Dosing With Anesthetic Agents

Clinical pharmacology and therapeutics, 2012-10, Vol.92 (4), p.417-419

2012

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Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation

The Journal of pharmacology and experimental therapeutics, 1987-01, Vol.240 (1), p.159

1987

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Absorption and bioavailability of oral transmucosal fentanyl citrate

Anesthesiology (Philadelphia), 1991-08, Vol.75 (2), p.223-229

1991

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Lumbar Epidural morphine in humans and supraspinal analgesia to experimental heat pain

Anesthesiology (Philadelphia), 2000-02, Vol.92 (2), p.312-324

2000

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Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans

Anesthesiology (Philadelphia), 1997-10, Vol.87 (4), p.884-899

1997

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Defining depth of anesthesia

Handbook of experimental pharmacology, 2008 (182), p.409

2008

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Application of physiologic models to predict the influence of changes in body composition and blood flows on the pharmacokinetics of fentanyl and alfentanil in patients

Anesthesiology (Philadelphia), 1998-03, Vol.88 (3), p.657-667

1998

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Electroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil

Anesthesiology (Philadelphia), 1991-01, Vol.74 (1), p.34-42

1991

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EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil

Anesthesiology (Philadelphia), 1985-03, Vol.62 (3), p.234-241

1985

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Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited

Anesthesiology (Philadelphia), 1990-03, Vol.72 (3), p.412-422

1990

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Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1051

1997

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Pharmacodynamics of orally administered sustained-release hydromorphone in humans

Anesthesiology (Philadelphia), 2001, Vol.94 (1), p.63-73

2001

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Thiopental pharmacodynamics. II: Quantitation of clinical and electroencephalographic depth of anesthesia

Anesthesiology (Philadelphia), 1992-08, Vol.77 (2), p.237-244

1992

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Improving the clinical utility of anesthetic drug pharmacokinetics

Anesthesiology (Philadelphia), 1992-03, Vol.76 (3), p.327-330

1992

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Pharmacokinetic-pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil

Clinical pharmacology and therapeutics, 1994-09, Vol.56 (3), p.261-271

1994

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Quantitation of depth of thiopental anesthesia in the rat

Anesthesiology (Philadelphia), 1996-02, Vol.84 (2), p.415-427

1996

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Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity

Anesthesiology (Philadelphia), 1996-06, Vol.84 (6), p.1411-1424

1996

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Pharmacokinetics and Pharmacodynamics of Intravenously Administered Anesthetic Drugs: Concepts and Lessons for Drug Development

The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling

A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

Linearity of pharmacokinetics and model estimation of sufentanil

Characterization and validation of a pharmacokinetic model for controlled‐release oxycodone

Absorption characteristics of transdermally administered fentanyl

PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats

Individualized Dosing With Anesthetic Agents

Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation

Absorption and bioavailability of oral transmucosal fentanyl citrate

Lumbar Epidural morphine in humans and supraspinal analgesia to experimental heat pain

Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans

Defining depth of anesthesia

Application of physiologic models to predict the influence of changes in body composition and blood flows on the pharmacokinetics of fentanyl and alfentanil in patients

Electroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil

EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil

Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited

Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat

Pharmacodynamics of orally administered sustained-release hydromorphone in humans

Thiopental pharmacodynamics. II: Quantitation of clinical and electroencephalographic depth of anesthesia

Improving the clinical utility of anesthetic drug pharmacokinetics

Pharmacokinetic-pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil

Quantitation of depth of thiopental anesthesia in the rat

Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity

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