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Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase

Virus research, 2008-06, Vol.134 (1), p.157-170

2008

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A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

Acta crystallographica. Section D, Biological crystallography., 2005-06, Vol.61 (6), p.651-657

2005

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Calcium regulation of chloroplast protein translocation is mediated by calmodulin binding to Tic32

Proceedings of the National Academy of Sciences - PNAS, 2006-10, Vol.103 (43), p.16051-16056

2006

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Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency

Frontiers in pediatrics, 2021-11, Vol.9, p.774747

2021

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Structure−Activity Relationship Studies of Novel Benzophenones Leading to the Discovery of a Potent, Next Generation HIV Nonnucleoside Reverse Transcriptase Inhibitor

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.727-739

2006

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Most children with cancer are not enrolled on a clinical trial in Canada: a population-based study

BMC cancer, 2017-06, Vol.17 (1), p.402-402, Article 402

2017

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Structures of R- and T-state Escherichia coli Aspartokinase III: MECHANISMS OF THE ALLOSTERIC TRANSITION AND INHIBITION BY LYSINE

The Journal of biological chemistry, 2006-10, Vol.281 (42), p.31544-31552

2006

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Structural Basis for the Improved Drug Resistance Profile of New Generation Benzophenone Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

Journal of medicinal chemistry, 2008-08, Vol.51 (16), p.5000-5008

2008

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Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

Nature structural & molecular biology, 2000-02, Vol.7 (2), p.127-133

2000

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HIV reverse transcriptase structures: designing new inhibitors and understanding mechanisms of drug resistance

Trends in pharmacological sciences (Regular ed.), 2005, Vol.26 (1), p.4-7

2005

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Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design

Biochemical journal, 2006-10, Vol.399 (2), p.199-204

2006

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Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations

BioMed research international, 2014-01, Vol.2014, p.945803-7

2014

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GTP Cyclohydrolase II Structure and Mechanism

The Journal of biological chemistry, 2005-11, Vol.280 (44), p.36912-36919

2005

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Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 1

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.5912-5922

2004

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Molecular Architecture and Ligand Recognition Determinants for T4 RNA Ligase

The Journal of biological chemistry, 2006-01, Vol.281 (3), p.1573-1579

2006

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Cancer incidence, morbidity, and survival in Canadian first nation children: A Manitoba population-based study from the cancer in young people in Canada (CYP-C) registry

Pediatric blood & cancer, 2014-12, Vol.61 (12), p.2164-2169

2014

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Structural Analysis of the Recognition of the Negative Regulator NmrA and DNA by the Zinc Finger from the GATA-Type Transcription Factor AreA

Journal of molecular biology, 2008-08, Vol.381 (2), p.373-382

2008

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Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2301-2309

2007

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Structural Basis for the Resilience of Efavirenz (DMP-266) to Drug Resistance Mutations in HIV-1 Reverse Transcriptase

Structure (London), 2000-10, Vol.8 (10), p.1089-1094

2000

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The Negative Transcriptional Regulator NmrA Discriminates between Oxidized and Reduced Dinucleotides

The Journal of biological chemistry, 2003-08, Vol.278 (34), p.32107-32114

2003

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Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

Nature structural & molecular biology, 1995-04, Vol.2 (4), p.303-308

1995

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Increasing Affinity of Interferon-γ Receptor 1 to Interferon-γ by Computer-Aided Design

BioMed research international, 2013-01, Vol.2013, p.752514-12

2013

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The Structure and Transcriptional Analysis of a Global Regulator from Neisseria meningitidis

The Journal of biological chemistry, 2007-05, Vol.282 (19), p.14655-14664

2007

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Engineering of a Single Conserved Amino Acid Residue of Herpes Simplex Virus Type 1 Thymidine Kinase Allows a Predominant Shift from Pyrimidine to Purine Nucleoside Phosphorylation

The Journal of biological chemistry, 2006-07, Vol.281 (28), p.19273-19279

2006

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Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus

Structure (London), 2002-12, Vol.10 (12), p.1687-1696

2002

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Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

Calcium regulation of chloroplast protein translocation is mediated by calmodulin binding to Tic32

Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency

Structure−Activity Relationship Studies of Novel Benzophenones Leading to the Discovery of a Potent, Next Generation HIV Nonnucleoside Reverse Transcriptase Inhibitor

Most children with cancer are not enrolled on a clinical trial in Canada: a population-based study

Structures of R- and T-state Escherichia coli Aspartokinase III: MECHANISMS OF THE ALLOSTERIC TRANSITION AND INHIBITION BY LYSINE

Structural Basis for the Improved Drug Resistance Profile of New Generation Benzophenone Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

HIV reverse transcriptase structures: designing new inhibitors and understanding mechanisms of drug resistance

Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design

Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations

GTP Cyclohydrolase II Structure and Mechanism

Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 1

Molecular Architecture and Ligand Recognition Determinants for T4 RNA Ligase

Cancer incidence, morbidity, and survival in Canadian first nation children: A Manitoba population-based study from the cancer in young people in Canada (CYP-C) registry

Structural Analysis of the Recognition of the Negative Regulator NmrA and DNA by the Zinc Finger from the GATA-Type Transcription Factor AreA

Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases

Structural Basis for the Resilience of Efavirenz (DMP-266) to Drug Resistance Mutations in HIV-1 Reverse Transcriptase

The Negative Transcriptional Regulator NmrA Discriminates between Oxidized and Reduced Dinucleotides

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

Increasing Affinity of Interferon-γ Receptor 1 to Interferon-γ by Computer-Aided Design

The Structure and Transcriptional Analysis of a Global Regulator from Neisseria meningitidis

Engineering of a Single Conserved Amino Acid Residue of Herpes Simplex Virus Type 1 Thymidine Kinase Allows a Predominant Shift from Pyrimidine to Purine Nucleoside Phosphorylation

Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus

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