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A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

Nature communications, 2023-02, Vol.14 (1), p.828-828, Article 828

2023

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Extravascular FIX and coagulation

Thrombosis journal, 2016-10, Vol.14 (Suppl 1), p.35-35, Article 35

Stafford, Darrel W

2016

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Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition

Blood, 2018-08, Vol.132 (6), p.647-657

2018

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γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K–dependent proteins

Blood, 2021-01, Vol.137 (4), p.533-543

2021

Volltextzugriff (PDF)

The Function of extravascular coagulation factor IX in haemostasis

Haemophilia : the official journal of the World Federation of Hemophilia, 2021-05, Vol.27 (3), p.332-339

2021

Volltextzugriff (PDF)

Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu

Blood, 2018-11, Vol.132 (18), p.1974-1984

2018

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Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study

Haematologica (Roma), 2020-08, Vol.105 (8), p.2164

2020

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Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice

Blood, 2016-07, Vol.128 (2), p.286-292

2016

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Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K‐dependent carboxylation

The FEBS journal, 2022-05, Vol.289 (9), p.2613-2627

2022

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Employing a gain-of-function factor IX variant R338L to advance the efficacy and safety of hemophilia B human gene therapy: preclinical evaluation supporting an ongoing adeno-associated virus clinical trial

Human gene therapy, 2015-02, Vol.26 (2), p.69

2015

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A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase

Journal of thrombosis and haemostasis, 2021-03, Vol.19 (3), p.689-700

2021

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Identification of the gene for vitamin K epoxide reductase

Nature, 2004-02, Vol.427 (6974), p.541-544

2004

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Functional study of the vitamin K cycle in mammalian cells

Blood, 2011-03, Vol.117 (10), p.2967-2974

2011

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Human Vitamin K Epoxide Reductase and Its Bacterial Homologue Have Different Membrane Topologies and Reaction Mechanisms

The Journal of biological chemistry, 2012-10, Vol.287 (41), p.33945-33955

2012

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FVIIa as used pharmacologically is not TF dependent in hemophilia B mice

Blood, 2014-03, Vol.123 (11), p.1764-1766

2014

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Characterization of vitamin K–dependent carboxylase mutations that cause bleeding and nonbleeding disorders

Blood, 2016-04, Vol.127 (15), p.1847-1855

2016

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Splice-Site Mutation of Exon 3 Deletion in the Gamma-Glutamyl Carboxylase Gene Causes Inactivation of the Enzyme

Journal of investigative dermatology, 2016-11, Vol.136 (11), p.2314-2317

2016

Volltextzugriff (PDF)

Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model

Blood, 2019-05, Vol.133 (22), p.2445-2451

2019

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A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle

Blood, 2020-08, Vol.136 (7), p.898-908

2020

Volltextzugriff (PDF)

Conformational Analysis of Membrane Proteins in Phospholipid Bilayer Nanodiscs by Hydrogen Exchange Mass Spectrometry

Analytical chemistry (Washington), 2010-07, Vol.82 (13), p.5415-5419

2010

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Conserved Loop Cysteines of Vitamin K Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Are Involved in Its Active Site Regeneration

The Journal of biological chemistry, 2014-03, Vol.289 (13), p.9396-9407

2014

Volltextzugriff (PDF)

Conformational Transitions in the Membrane Scaffold Protein of Phospholipid Bilayer Nanodiscs

Molecular & cellular proteomics, 2011-09, Vol.10 (9), p.M111.010876, Article M111.010876

2011

Volltextzugriff (PDF)

Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice

Biochemical journal, 2013-11, Vol.456 (1), p.47-54

2013

Volltextzugriff (PDF)

A Conformational Investigation of Propeptide Binding to the Integral Membrane Protein γ‑Glutamyl Carboxylase Using Nanodisc Hydrogen Exchange Mass Spectrometry

Biochemistry (Easton), 2014-03, Vol.53 (9), p.1511-1520

2014

Volltextzugriff (PDF)

Molecular basis of the first reported clinical case of congenital combined deficiency of coagulation factors

Blood, 2017-08, Vol.130 (7), p.948-951

2017

Volltextzugriff (PDF)

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(28)
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A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

Extravascular FIX and coagulation

Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition

γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K–dependent proteins

The Function of extravascular coagulation factor IX in haemostasis

Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu

Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study

Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice

Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K‐dependent carboxylation

Employing a gain-of-function factor IX variant R338L to advance the efficacy and safety of hemophilia B human gene therapy: preclinical evaluation supporting an ongoing adeno-associated virus clinical trial

A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase

Identification of the gene for vitamin K epoxide reductase

Functional study of the vitamin K cycle in mammalian cells

Human Vitamin K Epoxide Reductase and Its Bacterial Homologue Have Different Membrane Topologies and Reaction Mechanisms

FVIIa as used pharmacologically is not TF dependent in hemophilia B mice

Characterization of vitamin K–dependent carboxylase mutations that cause bleeding and nonbleeding disorders

Splice-Site Mutation of Exon 3 Deletion in the Gamma-Glutamyl Carboxylase Gene Causes Inactivation of the Enzyme

Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model

A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle

Conformational Analysis of Membrane Proteins in Phospholipid Bilayer Nanodiscs by Hydrogen Exchange Mass Spectrometry

Conserved Loop Cysteines of Vitamin K Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Are Involved in Its Active Site Regeneration

Conformational Transitions in the Membrane Scaffold Protein of Phospholipid Bilayer Nanodiscs

Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice

A Conformational Investigation of Propeptide Binding to the Integral Membrane Protein γ‑Glutamyl Carboxylase Using Nanodisc Hydrogen Exchange Mass Spectrometry

Molecular basis of the first reported clinical case of congenital combined deficiency of coagulation factors

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