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Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

Scientific reports, 2017-09, Vol.7 (1), p.10492-10492, Article 10492

2017

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Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease

Acta neuropathologica communications, 2020-02, Vol.8 (1), p.13-13, Article 13

2020

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Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification

Haematologica (Roma), 2020-05, Vol.105 (5), p.e206-e209

2020

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Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

Scientific reports, 2016-11, Vol.6 (1), p.37798-37798, Article 37798

2016

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High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy

SLAS discovery, 2023-04, Vol.28 (3), p.73-87

2023

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Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

Biochemical journal, 2021-12, Vol.478 (23), p.4099-4118

2021

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Advancing novel therapies for neurodegeneration through an innovative model for industry–academia collaborations: A decade of the Eisai–UCL experience

Drug discovery today, 2023-10, Vol.28 (10), p.103732-103732, Article 103732

2023

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Cyclic AMP Blocks Bacterial Lipopolysaccharide-Induced Myosin Light Chain Phosphorylation in Endothelial Cells Through Inhibition of Rho/Rho Kinase Signaling

The Journal of immunology (1950), 2000-06, Vol.164 (12), p.6543-6549

2000

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Identification of pyrimidinyl piperazines as non-iminosugar glucocerebrosidase (GCase) pharmacological chaperones

Bioorganic & medicinal chemistry letters, 2023-02, Vol.81, p.129130-129130, Article 129130

2023

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Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2

FEBS letters, 2003-06, Vol.545 (2), p.161-166

2003

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Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms

The Journal of biological chemistry, 2001-03, Vol.276 (13), p.10423-10431

2001

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Heme oxygenase modulates oxidant-signaled airway smooth muscle contractility: role of bilirubin

American journal of physiology. Lung cellular and molecular physiology, 2002-09, Vol.283 (3), p.596-L603

2002

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Occludin as a possible determinant of tight junction permeability in endothelial cells

Journal of cell science, 1997-07, Vol.110 ( Pt 14) (14), p.1603-1613

1997

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Cytotoxic Necrotizing Factor 1 of Escherichia coli Stimulates Rho/Rho-Kinase-Dependent Myosin Light-Chain Phosphorylation without Inactivating Myosin Light-Chain Phosphatase in Endothelial Cells

Infection and Immunity, 2003-09, Vol.71 (9), p.5188-5193

2003

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Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase

Journal of cell science, 2003-12, Vol.116 (Pt 23), p.4777-4790

2003

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The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4666-4670

2005

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Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

Journal of neurochemistry, 1997-03, Vol.68 (3), p.991-1000

1997

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Amphiphysin I phosphorylation on residue threonine 260 in a pentylenetetrazole-induced seizure model

Neuroscience letters, 2008-10, Vol.444 (3), p.245-249

2008

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p120, a p120-Related Protein (p100), and the Cadherin/Catenin Complex

The Journal of cell biology, 1995-07, Vol.130 (2), p.369-381

1995

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Cell adhesion, cell junctions and the blood—brain barrier

Current opinion in neurobiology, 1996-10, Vol.6 (5), p.622-627

1996

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High-throughput methods to detect dimerization of Bcl-2 family proteins

Analytical biochemistry, 2003-11, Vol.322 (2), p.170-178

2003

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Development of a pentylenetetrazole-induced seizure model to evaluate kinase inhibitor efficacy in the central nervous system

Neuroscience letters, 2006-03, Vol.395 (2), p.143-148

2006

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Dephosphorylation of the Cadherin-associated p100/p120 Proteins in Response to Activation of Protein Kinase C in Epithelial Cells

The Journal of biological chemistry, 1997-12, Vol.272 (50), p.31894-31901

1997

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Treatment with BBB022A or rolipram stabilizes the blood-brain barrier in experimental autoimmune encephalomyelitis: an additional mechanism for the therapeutic effect of type IV phosphodiesterase inhibitors

Journal of neuroimmunology, 1999-06, Vol.97 (1), p.119-128

1999

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Evidence that tyrosine phosphorylation may increase tight junction permeability

Journal of cell science, 1995-02, Vol.108 ( Pt 2) (2), p.609-619

1995

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Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease

Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

Advancing novel therapies for neurodegeneration through an innovative model for industry–academia collaborations: A decade of the Eisai–UCL experience

Cyclic AMP Blocks Bacterial Lipopolysaccharide-Induced Myosin Light Chain Phosphorylation in Endothelial Cells Through Inhibition of Rho/Rho Kinase Signaling

Identification of pyrimidinyl piperazines as non-iminosugar glucocerebrosidase (GCase) pharmacological chaperones

Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2

Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms

Heme oxygenase modulates oxidant-signaled airway smooth muscle contractility: role of bilirubin

Occludin as a possible determinant of tight junction permeability in endothelial cells

Cytotoxic Necrotizing Factor 1 of Escherichia coli Stimulates Rho/Rho-Kinase-Dependent Myosin Light-Chain Phosphorylation without Inactivating Myosin Light-Chain Phosphatase in Endothelial Cells

Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase

The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

Amphiphysin I phosphorylation on residue threonine 260 in a pentylenetetrazole-induced seizure model

p120, a p120-Related Protein (p100), and the Cadherin/Catenin Complex

Cell adhesion, cell junctions and the blood—brain barrier

High-throughput methods to detect dimerization of Bcl-2 family proteins

Development of a pentylenetetrazole-induced seizure model to evaluate kinase inhibitor efficacy in the central nervous system

Dephosphorylation of the Cadherin-associated p100/p120 Proteins in Response to Activation of Protein Kinase C in Epithelial Cells

Treatment with BBB022A or rolipram stabilizes the blood-brain barrier in experimental autoimmune encephalomyelitis: an additional mechanism for the therapeutic effect of type IV phosphodiesterase inhibitors

Evidence that tyrosine phosphorylation may increase tight junction permeability

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