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Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

Frontiers in pharmacology, 2019-08, Vol.10, p.840-840

2019

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Fluorescent False Neurotransmitters Visualize Dopamine Release from Individual Presynaptic Terminals

Science (American Association for the Advancement of Science), 2009-06, Vol.324 (5933), p.1441-1444

2009

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PKC θ activity maintains normal quantal size in chromaffin cells

Journal of neurochemistry, 2008-06, Vol.105 (5), p.1635-1641

2008

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Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor

Glia, 2016-10, Vol.64 (10), p.1788-1794

2016

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KCa3.1-a microglial target ready for drug repurposing?

Glia, 2016-10, Vol.64 (10), p.1733-1741

2016

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Senicapoc: Repurposing a Drug to Target Microglia KCa3.1 in Stroke

Neurochemical research, 2017-09, Vol.42 (9), p.2639-2645

2017

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Soluble Aβ from PSAPP mice is different to that extracted from Alzheimer patients

Alzheimer's & dementia, 2010-07, Vol.6 (4), p.S242-S243

2010

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Amyloid beta induces changes in NMDA and AMPA receptor trafficking in primary neuronal cultures and brain slices

Alzheimer's & dementia, 2009-07, Vol.5 (4), p.P304-P304

2009

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Dopamine neurons release transmitter via a flickering fusion pore

Nature neuroscience, 2004-04, Vol.7 (4), p.341-346

2004

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Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain

Purinergic signalling, 2022-12, Vol.18 (4), p.499-514

2022

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Alpha-synuclein overexpression increases cytosolic catecholamine concentration

The Journal of neuroscience, 2006-09, Vol.26 (36), p.9304-9311

2006

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Inhibition of the potassium channel KCa3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury

European journal of pharmacology, 2017-01, Vol.795, p.1-7

2017

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Interactions of 1-methyl-4-phenylpyridinium and other compounds with P-glycoprotein: relevance to toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Brain research, 2001-08, Vol.910 (1), p.116-125

2001

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Inhibition of the potassium channel K Ca 3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury

European journal of pharmacology, 2017-01, Vol.795, p.1-7

2017

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Analysis of VMAT2 binding after methamphetamine or MPTP treatment: disparity between homogenates and vesicle preparations

Journal of neurochemistry, 2000-05, Vol.74 (5), p.2217-2220

2000

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Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata

The Journal of pharmacology and experimental therapeutics, 2000-05, Vol.293 (2), p.336

2000

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Recent Developments in Targeting Neuroinflammation in Disease

Annual Reports in Medicinal Chemistry, 2012, Vol.47, p.37-53

2012

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P2‐147: Amyloid beta induces changes in NMDA and AMPA receptor trafficking in primary neuronal cultures and brain slices

Alzheimer's & dementia, 2009-07, Vol.5 (4S_Part_10), p.P304-P304

2009

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In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2): rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridinium

The Journal of pharmacology and experimental therapeutics, 2000-05, Vol.293 (2), p.329

2000

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P1‐238: Soluble Aβ from PSAPP mice is different to that extracted from Alzheimer patients

Alzheimer's & dementia, 2010-07, Vol.6 (4S_Part_8), p.S242-S243

2010

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Dopamine release at individual presynaptic terminals visualized with FFNs

Journal of visualized experiments, 2009-08 (30)

2009

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Chapter 3 Small-Molecule Protein–Protein Interaction Inhibitors as Therapeutic Agents for Neurodegenerative Diseases: Recent Progress and Future Directions

Annual Reports in Medicinal Chemistry, 2009, Vol.44, p.51-69

2009

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Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

Fluorescent False Neurotransmitters Visualize Dopamine Release from Individual Presynaptic Terminals

PKC θ activity maintains normal quantal size in chromaffin cells

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor

KCa3.1-a microglial target ready for drug repurposing?

Senicapoc: Repurposing a Drug to Target Microglia KCa3.1 in Stroke

Soluble Aβ from PSAPP mice is different to that extracted from Alzheimer patients

Amyloid beta induces changes in NMDA and AMPA receptor trafficking in primary neuronal cultures and brain slices

Dopamine neurons release transmitter via a flickering fusion pore

Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain

Alpha-synuclein overexpression increases cytosolic catecholamine concentration

Inhibition of the potassium channel KCa3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury

Interactions of 1-methyl-4-phenylpyridinium and other compounds with P-glycoprotein: relevance to toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Inhibition of the potassium channel K Ca 3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury

Analysis of VMAT2 binding after methamphetamine or MPTP treatment: disparity between homogenates and vesicle preparations

Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata

Recent Developments in Targeting Neuroinflammation in Disease

P2‐147: Amyloid beta induces changes in NMDA and AMPA receptor trafficking in primary neuronal cultures and brain slices

In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2): rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridinium

P1‐238: Soluble Aβ from PSAPP mice is different to that extracted from Alzheimer patients

Dopamine release at individual presynaptic terminals visualized with FFNs

Chapter 3 Small-Molecule Protein–Protein Interaction Inhibitors as Therapeutic Agents for Neurodegenerative Diseases: Recent Progress and Future Directions

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