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The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

Antiviral research, 2015-03, Vol.115, p.21-38

2015

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Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS

The Journal of biological chemistry, 2015-08, Vol.290 (32), p.19403-19422

2015

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Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

Bioorganic & medicinal chemistry, 2015-09, Vol.23 (17), p.6036-6048

2015

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Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2

Bioorganic & medicinal chemistry, 2013-10, Vol.21 (19), p.6022-6037

2013

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X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus

Scientific reports, 2016-05, Vol.6 (1), p.25961-25961, Article 25961

2016

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X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5072-5077

2015

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Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance

Journal of virology, 2014-10, Vol.88 (20), p.11886-11898

2014

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Structural studies and cyclization of the neuroprotective octapeptide NAPVSIPQ to improve cell permeability

Peptide science (Hoboken, N.J.), 2020-07, Vol.112 (4), p.n/a

2020

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A structure-guided taxonomicbased approach to the design of broad-spectrum coronavirus protease inhibitors

Acta crystallographica. Section A, Foundations and advances, 2021-08, Vol.77 (a2), p.C197-C197

2021

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A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses

Journal of virology, 2014-10, Vol.88 (20), p.11825-11833

2014

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Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

Bioorganic & medicinal chemistry, 2015-09, Vol.23 (17)

2015

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A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses

Journal of virology, 2014-10, Vol.88 (20), p.11825-11833

2014

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X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22)

2015

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Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)

The Journal of biological chemistry, 2015-08, Vol.290 (32), p.19403-19422

2015

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Prevalence of Nonsuicidal Self-Injury in Nonclinical Samples: Systematic Review, Meta-Analysis and Meta-Regression

Suicide & life-threatening behavior, 2014-06, Vol.44 (3), p.273-303

2014

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The UK10K project identifies rare variants in health and disease

Nature (London), 2015-10, Vol.526 (7571), p.82-90

2015

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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

Cancer cell, 2019-05, Vol.35 (5), p.721-737.e9

2019

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Outcome after conservative management or intervention for unruptured brain arteriovenous malformations

JAMA : the journal of the American Medical Association, 2014-04, Vol.311 (16), p.1661

2014

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Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

Nature communications, 2015-09, Vol.6 (1), p.8111-8111, Article 8111

2015

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Mining the human phenome using allelic scores that index biological intermediates

PLoS genetics, 2013-10, Vol.9 (10), p.e1003919-e1003919

2013

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New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nature genetics, 2019-03, Vol.51 (3), p.481-493

2019

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Long‐term exclusion of invasive ungulates alters tree recruitment and functional traits but not total forest carbon

Ecological applications, 2023-06, Vol.33 (4), p.e2836-n/a

2023

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General and age-specific fertility rates in non-affective psychosis: population-based analysis of Scottish women

Social Psychiatry and Psychiatric Epidemiology, 2023-01, Vol.58 (1), p.105-112

2023

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Genome-wide and fine-resolution association analysis of malaria in West Africa

Nature genetics, 2009-06, Vol.41 (6), p.657-665

2009

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Schizotypy-Related Magnetization of Cortex in Healthy Adolescence Is Colocated With Expression of Schizophrenia-Related Genes

Biological psychiatry (1969), 2020-08, Vol.88 (3), p.248-259

2020

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The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS

Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2

X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance

Structural studies and cyclization of the neuroprotective octapeptide NAPVSIPQ to improve cell permeability

A structure-guided taxonomicbased approach to the design of broad-spectrum coronavirus protease inhibitors

A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses

Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)

Prevalence of Nonsuicidal Self-Injury in Nonclinical Samples: Systematic Review, Meta-Analysis and Meta-Regression

The UK10K project identifies rare variants in health and disease

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

Outcome after conservative management or intervention for unruptured brain arteriovenous malformations

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

Mining the human phenome using allelic scores that index biological intermediates

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Long‐term exclusion of invasive ungulates alters tree recruitment and functional traits but not total forest carbon

General and age-specific fertility rates in non-affective psychosis: population-based analysis of Scottish women

Genome-wide and fine-resolution association analysis of malaria in West Africa

Schizotypy-Related Magnetization of Cortex in Healthy Adolescence Is Colocated With Expression of Schizophrenia-Related Genes

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