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Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Pflügers Archiv, 2019-05, Vol.471 (5), p.701-717

Spudich, James A.

2019

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Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases

Biophysical journal, 2014-03, Vol.106 (6), p.1236-1249

Spudich, James A.

2014

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The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

Biochemical Society transactions, 2015-02, Vol.43 (1), p.64-72

Spudich, James A

2015

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One must reconstitute the functions of interest from purified proteins

Frontiers in physiology, 2024-05, Vol.15, p.1390186-1390186

Spudich, James A

2024

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Optimized localization analysis for single-molecule tracking and super-resolution microscopy

Nature methods, 2010-05, Vol.7 (5), p.377-381

2010

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The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Nature structural & molecular biology, 2017-06, Vol.24 (6), p.525-533

2017

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Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy

Circulation (New York, N.Y.), 2021-11, Vol.144 (21), p.1714-1731

2021

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A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

Science (American Association for the Advancement of Science), 2016-02, Vol.351 (6273), p.617-621

2016

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Cryo-EM structure of the folded-back state of human β-cardiac myosin

Nature communications, 2023-05, Vol.14 (1), p.3166-12, Article 3166

2023

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From amoeboid myosin to unique targeted medicines for a genetic cardiac disease

Frontiers in physiology, 2024-10, Vol.15

Spudich, James A.

2024

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Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies

Frontiers in physiology, 2022-09, Vol.13, p.975076-975076

2022

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Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments

Nature nanotechnology, 2015-08, Vol.10 (8), p.696-700

2015

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Systematic control of protein interaction using a modular ER/K α-helix linker

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (51), p.20467-20472

2011

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β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Nature communications, 2019-06, Vol.10 (1), p.2685-10, Article 2685

2019

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Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (31), p.12607-12612

2013

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Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

Cell reports (Cambridge), 2015-05, Vol.11 (6), p.910-920

2015

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Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light

Biophysical reviews, 2018-02, Vol.10 (1), p.27-48

2018

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Dynamics of the unbound head during myosin V processive translocation

Nature structural & molecular biology, 2007-03, Vol.14 (3), p.246-248

2007

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Optimized measurements of separations and angles between intra-molecular fluorescent markers

Nature communications, 2015-10, Vol.6 (1), p.8621-8621, Article 8621

2015

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The myosin swinging cross-bridge model

Nature reviews. Molecular cell biology, 2001-05, Vol.2 (5), p.387-392

Spudich, James A

2001

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power stroke of myosin VI and the basis of reverse directionality

Proceedings of the National Academy of Sciences - PNAS, 2007-01, Vol.104 (3), p.772-777

2007

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Single Molecule High-Resolution Colocalization of Cy3 and Cy5 Attached to Macromolecules Measures Intramolecular Distances through Time

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (5), p.1419-1423

2005

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Validation of the SCEC Broadband Platform V14.3 Simulation Methods Using Pseudospectral Acceleration Data

Seismological research letters, 2015-01, Vol.86 (1), p.39-47

2015

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The Mechanism of Myosin VI Translocation and Its Load-Induced Anchoring

Cell, 2004-03, Vol.116 (5), p.737-749

2004

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Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin

PloS one, 2013-12, Vol.8 (12), p.e83403-e83403

2013

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Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

One must reconstitute the functions of interest from purified proteins

Optimized localization analysis for single-molecule tracking and super-resolution microscopy

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

Cryo-EM structure of the folded-back state of human β-cardiac myosin

From amoeboid myosin to unique targeted medicines for a genetic cardiac disease

Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies

Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments

Systematic control of protein interaction using a modular ER/K α-helix linker

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light

Dynamics of the unbound head during myosin V processive translocation

Optimized measurements of separations and angles between intra-molecular fluorescent markers

The myosin swinging cross-bridge model

power stroke of myosin VI and the basis of reverse directionality

Single Molecule High-Resolution Colocalization of Cy3 and Cy5 Attached to Macromolecules Measures Intramolecular Distances through Time

Validation of the SCEC Broadband Platform V14.3 Simulation Methods Using Pseudospectral Acceleration Data

The Mechanism of Myosin VI Translocation and Its Load-Induced Anchoring

Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin

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