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Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

The New England journal of medicine, 2014-03, Vol.370 (10), p.901-910

2014

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Delayed administration of a bio-engineered zinc-finger VEGF-A gene therapy is neuroprotective and attenuates allodynia following traumatic spinal cord injury

PloS one, 2014-05, Vol.9 (5), p.e96137-e96137

2014

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An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury

Neurobiology of disease, 2010-02, Vol.37 (2), p.384-393

2010

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Treatment of traumatic brain injury using zinc-finger protein gene therapy targeting VEGF-A

Journal of neurotrauma, 2012-11, Vol.29 (17), p.2647-2659

2012

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Induction of angiogenesis in a mouse model using engineered transcription factors

Nature medicine, 2002-12, Vol.8 (12), p.1427-1432

2002

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A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart

Molecular therapy, 2012-08, Vol.20 (8), p.1508-1515

2012

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Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy

Diabetes (New York, N.Y.), 2006-06, Vol.55 (6), p.1847-1854

2006

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Zinc-Finger Protein-Targeted Gene Regulation: Genomewide Single-Gene Specificity

Proceedings of the National Academy of Sciences - PNAS, 2003-10, Vol.100 (21), p.11997-12002

2003

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Engineered Zinc Finger Protein–Mediated VEGF-A Activation Restores Deficient VEGF-A in Sensory Neurons in Experimental Diabetes

Diabetes (New York, N.Y.), 2010-02, Vol.59 (2), p.509-518

2010

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Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5

Human gene therapy, 2013-03, Vol.24 (3), p.245

2013

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ZFN-Mediated Gene Targeting at the Albumin Locus in Liver Results in Therapeutic Levels of Human FIX in Mice and Non-Human Primates

Blood, 2015-12, Vol.126 (23), p.200-200

2015

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Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease–Targeted Disruption of the HIV Co-receptor CCR5

Human gene therapy, 2013-03, Vol.24 (3), p.245-258

2013

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Ocular Gene Transfer with Self-Complementary AAV Vectors

Investigative ophthalmology & visual science, 2007-07, Vol.48 (7), p.3324-3328

2007

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Gene therapy for traumatic central nervous system injury and stroke using an engineered zinc finger protein that upregulates VEGF-A

Journal of neurotrauma, 2011-09, Vol.28 (9), p.1863-1879

2011

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Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

Nature genetics, 1997-07, Vol.16 (3), p.270-276

1997

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Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia

Circulation (New York, N.Y.), 2004-10, Vol.110 (16), p.2467-2475

2004

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Prolonged Production of NADPH Oxidase-Corrected Granulocytes after Gene Therapy of Chronic Granulomatous Disease

Proceedings of the National Academy of Sciences - PNAS, 1997-10, Vol.94 (22), p.12133-12138

1997

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Selective uptake and sustained expression of AAV vectors following subcutaneous delivery

The journal of gene medicine, 1999-01, Vol.1 (1), p.31-42

1999

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Efficient and stable adeno-associated virus-mediated transduction in the skeletal muscle of adult immunocompetent mice

Human gene therapy, 1997-11, Vol.8 (16), p.1891-1900

1997

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Intramuscular administration of a VEGF zinc finger transcription factor activator (VEGF-ZFP-TF) improves functional outcomes in SOD1 rats

Amyotrophic lateral sclerosis, 2011-09, Vol.12 (5), p.331-339

2011

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Comparison of systemic routes of administration for CLN3 delivery via scAAV9

Molecular genetics and metabolism, 2017-01, Vol.120 (1-2), p.S127-S127

2017

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Retroviral particles produced from a stable human-derived packaging cell line transduce target cells with very high efficiencies

Human gene therapy, 1997-08, Vol.8 (12), p.1459-1467

1997

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239. Preclinical Studies for the First Hematopoietic Stem Cell (HSC) Gene Editing Trial: Phase 1 Study of Beta-Thalassemia With Autologous Transplantation of Zinc Finger Nuclease-Treated HSC To Upregulate Fetal Hemoglobin

Molecular therapy, 2015-05, Vol.23, p.S93-S94

2015

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Synthetic Zinc Finger Transcription Factor Action at an Endogenous Chromosomal Site

The Journal of biological chemistry, 2000-10, Vol.275 (43), p.33850-33860

2000

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Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A

The Journal of biological chemistry, 2001-04, Vol.276 (14), p.11323-11334

2001

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Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

Delayed administration of a bio-engineered zinc-finger VEGF-A gene therapy is neuroprotective and attenuates allodynia following traumatic spinal cord injury

An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury

Treatment of traumatic brain injury using zinc-finger protein gene therapy targeting VEGF-A

Induction of angiogenesis in a mouse model using engineered transcription factors

A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart

Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy

Zinc-Finger Protein-Targeted Gene Regulation: Genomewide Single-Gene Specificity

Engineered Zinc Finger Protein–Mediated VEGF-A Activation Restores Deficient VEGF-A in Sensory Neurons in Experimental Diabetes

Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5

ZFN-Mediated Gene Targeting at the Albumin Locus in Liver Results in Therapeutic Levels of Human FIX in Mice and Non-Human Primates

Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease–Targeted Disruption of the HIV Co-receptor CCR5

Ocular Gene Transfer with Self-Complementary AAV Vectors

Gene therapy for traumatic central nervous system injury and stroke using an engineered zinc finger protein that upregulates VEGF-A

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia

Prolonged Production of NADPH Oxidase-Corrected Granulocytes after Gene Therapy of Chronic Granulomatous Disease

Selective uptake and sustained expression of AAV vectors following subcutaneous delivery

Efficient and stable adeno-associated virus-mediated transduction in the skeletal muscle of adult immunocompetent mice

Intramuscular administration of a VEGF zinc finger transcription factor activator (VEGF-ZFP-TF) improves functional outcomes in SOD1 rats

Comparison of systemic routes of administration for CLN3 delivery via scAAV9

Retroviral particles produced from a stable human-derived packaging cell line transduce target cells with very high efficiencies

239. Preclinical Studies for the First Hematopoietic Stem Cell (HSC) Gene Editing Trial: Phase 1 Study of Beta-Thalassemia With Autologous Transplantation of Zinc Finger Nuclease-Treated HSC To Upregulate Fetal Hemoglobin

Synthetic Zinc Finger Transcription Factor Action at an Endogenous Chromosomal Site

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A

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