UB Paderborn / Katalog / Suche / in CDI

Sortiert nach

Einfacher Volltextzugriff von (fast) überall

Installieren Sie die LibKey Nomad-Browsererweiterung und erhalten Sie von vielen Webseiten einfachen Zugriff auf lizenzierte Volltexte oder Open Access Publikationen. Mehr erfahren...

Mini‐Review: Comprehensive Drug Disposition Knowledge Generated in the Modern Human Radiolabeled ADME Study

CPT: pharmacometrics and systems pharmacology, 2020-08, Vol.9 (8), p.428-434

2020

Volltextzugriff (PDF)

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

Drug metabolism and disposition, 2005-01, Vol.33 (1), p.165-174

2005

Volltextzugriff (PDF)

Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance

Drug metabolism and disposition, 2023-06, Vol.51 (6), p.647-656

2023

Volltextzugriff (PDF)

Effective Application of Metabolite Profiling in Drug Design and Discovery

Journal of medicinal chemistry, 2020-06, Vol.63 (12), p.6387-6406

2020

Volltextzugriff (PDF)

Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group

Clinical pharmacology and therapeutics, 2024-05, Vol.115 (5), p.939-953

2024

Volltextzugriff (PDF)

Considerations for Human ADME Strategy and Design Paradigm Shift(s) – An Industry White Paper

Clinical pharmacology and therapeutics, 2023-04, Vol.113 (4), p.775-781

2023

Volltextzugriff (PDF)

A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance

Drug metabolism and disposition, 2018-06, Vol.46 (6), p.865-878

2018

Volltextzugriff (PDF)

Non‐Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece

Clinical pharmacology and therapeutics, 2024-05, Vol.115 (5), p.931-938

2024

Volltextzugriff (PDF)

Recommendations on the Use of Multiple Labels in Human Mass Balance Studies

Drug metabolism and disposition, 2024-03, Vol.52 (3), p.153

2024

Volltextzugriff (PDF)

Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies

Drug metabolism and disposition, 2014-10, Vol.42 (10), p.1627-1639

2014

Volltextzugriff (PDF)

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Drug metabolism and disposition, 2012-03, Vol.40 (3), p.625-634

2012

Volltextzugriff (PDF)

Differential Effects of Various Typical and Atypical Antipsychotics on Plasma Glucose and Insulin Levels in the Mouse: Evidence for the Involvement of Sympathetic Regulation

Schizophrenia bulletin, 2010-03, Vol.36 (2), p.410-418

2010

Volltextzugriff (PDF)

Quantitative projection of human brain penetration of the H 3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy

Xenobiotica, 2017-02, Vol.47 (2), p.119-126

2017

Volltextzugriff (PDF)

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139

The Journal of pharmacology and experimental therapeutics, 2006-11, Vol.319 (2), p.924-933

2006

Volltextzugriff (PDF)

Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy

Xenobiotica, 2017-02, Vol.47 (2), p.119-126

2017

Volltextzugriff (PDF)

3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2524-2529

2009

Volltextzugriff (PDF)

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates - subtype selective, high affinity alpha 7 nicotinic acetylcholine receptor agonists

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4747-4751

2009

Volltextzugriff (PDF)

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates – subtype selective, high affinity α7 nicotinic acetylcholine receptor agonists

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4747-4751

2009

Volltextzugriff (PDF)

The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine release

European journal of pharmacology, 2005-01, Vol.506 (3), p.209-219

2005

Volltextzugriff (PDF)

Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro

The Journal of pharmacology and experimental therapeutics, 1997-04, Vol.281 (1), p.400

1997

Volltextzugriff (PDF)

Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure–Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H 1 Receptor Inverse Agonist

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.7268-7292

2020

Volltextzugriff (PDF)

Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure–Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H1 Receptor Inverse Agonist

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.7268-7292

2020

Volltextzugriff (PDF)

Discovery of Two Clinical Histamine H 3 Receptor Antagonists: trans - N -Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans -3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]- N -(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

Journal of medicinal chemistry, 2011-11, Vol.54 (21), p.7602-7620

2011

Volltextzugriff (PDF)

1 – 25 von 34

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(33)
Mit Volltextzugriff
(24)

Publikationsform

Artikel
(34)

Sprache

Englisch
(34)

Erscheinungsjahr

n.n

Thema

Science & Technology
(25)
Life Sciences & Biomedicine
(24)
Pharmacology & Pharmacy
(23)
Humans
(14)
Animals
(13)
Male
(8)
Rats
(8)
Biological And Medical Sciences
(7)
Chemistry, Medicinal
(7)
Medical Sciences
(7)
Pharmacology. Drug Treatments
(7)
Neuropharmacology
(5)
Anesthetics, Inhalation - Metabolism
(4)
Chemistry
(4)
Physical Sciences
(4)
Psychology. Psychoanalysis. Psychiatry
(4)
Psychopharmacology
(4)
Rats, Sprague-Dawley
(4)
Biotransformation
(3)
Dose-Response Relationship, Drug
(3)

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

Mini‐Review: Comprehensive Drug Disposition Knowledge Generated in the Modern Human Radiolabeled ADME Study

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance

Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models

Effective Application of Metabolite Profiling in Drug Design and Discovery

Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group

Considerations for Human ADME Strategy and Design Paradigm Shift(s) – An Industry White Paper

A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance

Non‐Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece

Recommendations on the Use of Multiple Labels in Human Mass Balance Studies

Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Differential Effects of Various Typical and Atypical Antipsychotics on Plasma Glucose and Insulin Levels in the Mouse: Evidence for the Involvement of Sympathetic Regulation

Quantitative projection of human brain penetration of the H 3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139

Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy

3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates - subtype selective, high affinity alpha 7 nicotinic acetylcholine receptor agonists

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates – subtype selective, high affinity α7 nicotinic acetylcholine receptor agonists

The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine release

Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro

Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure–Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H 1 Receptor Inverse Agonist

Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure–Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H1 Receptor Inverse Agonist

Discovery of Two Clinical Histamine H 3 Receptor Antagonists: trans - N -Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans -3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]- N -(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

Suchergebnisse filtern