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Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells

Oncogene, 2005-09, Vol.24 (41), p.6213-6221

2005

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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

Oncogene, 2002-09, Vol.21 (41), p.6255-6263

2002

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Truncated ErbB2 receptor (p95 ) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR ErbB2 kinase inhibitor GW572016

Oncogene, 2004-01, Vol.23 (3), p.646-653

2004

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Anti-B4-blocked ricin: a phase I trial of 7-day continuous infusion in patients with B-cell neoplasms

Journal of clinical oncology, 1993-04, Vol.11 (4), p.726-737

1993

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28-kDa Mammalian Heat Shock Protein, a Novel Substrate of a Growth Regulatory Protease Involved in Differentiation of Human Leukemia Cells (∗)

The Journal of biological chemistry, 1995-01, Vol.270 (3), p.1003-1006

1995

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Heat shock protein is a unique marker of growth arrest during macrophage differentiation of HL-60 cells

Journal of cellular physiology, 1993-09, Vol.156 (3), p.619-625

1993

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Abstract PL2-1: Drug Development — Targeting HER2 beyond Trastuzumab

Cancer research (Chicago, Ill.), 2010-12, Vol.70 (24_Supplement), p.PL2-1-PL2-1

NL, Spector

2010

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Growth arrest of human B lymphocytes is accompanied by induction of the low molecular weight mammalian heat shock protein (Hsp28)

The Journal of immunology (1950), 1992-03, Vol.148 (6), p.1668-1673

1992

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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53

Science signaling, 2013-05, Vol.6 (274), p.ra32

2013

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Regulation of the 28 kDa heat shock protein by retinoic acid during differentiation of human leukemic HL-60 cells

FEBS letters, 1994-01, Vol.337 (2), p.184-188

1994

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Phase I Safety, Pharmacokinetics, and Clinical Activity Study of Lapatinib (GW572016), a Reversible Dual Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinases, in Heavily Pretreated Patients With Metastatic Carcinomas

Journal of clinical oncology, 2005-08, Vol.23 (23), p.5305-5313

2005

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Sensitization of tumor cells to Fas killing through overexpression of heat-shock transcription factor 1

Journal of cellular physiology, 2000-06, Vol.183 (3), p.425-431

2000

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Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies

Journal of clinical oncology, 2005-04, Vol.23 (11), p.2502-2512

2005

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Truncation of Sp1 transcription factor by myeloblastin in undifferentiated HL60 cells

Journal of cellular physiology, 1998-05, Vol.175 (2), p.121-128

1998

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Activation primes human B lymphocytes to respond to heat shock

The Journal of experimental medicine, 1989-11, Vol.170 (5), p.1763-1768

1989

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Regulation of survivin by ErbB2 signaling : Therapeutic implications for ErbB2-overexpressing breast cancers

Cancer research (Chicago, Ill.), 2006-02, Vol.66 (3), p.1640-1647

2006

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A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon

International journal of radiation oncology, biology, physics, 2004-03, Vol.58 (3), p.779-785

2004

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Tumor Selective G2/M Cell Cycle Arrest and Apoptosis of Epithelial and Hematological Malignancies by BBL22, a Benzazepine

Proceedings of the National Academy of Sciences - PNAS, 2000-06, Vol.97 (13), p.7494-7499

2000

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Abstract P4-08-03: The impact of the heregulin-HER receptor signaling axis on response to HER tyrosine kinase inhibitors

Cancer research (Chicago, Ill.), 2012-12, Vol.72 (24_Supplement), p.P4-P4-08-03

2012

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Activation of the AMPK regulated metabolic stress response by a small molecule HER2/EGFR tyrosine kinase inhibitor protects cardiac myocytes from apoptotic stimuli

Journal of clinical oncology, 2007-06, Vol.25 (18_suppl), p.14000-14000

2007

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Activation signals regulate heat shock transcription factor 1 in human B lymphocytes

Journal of cellular physiology, 1997-03, Vol.170 (3), p.235-240

1997

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Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects

Investigational new drugs, 2005-01, Vol.23 (1), p.39-49

2005

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EGF103009, a phase II trial of lapatinib monotherapy in patients with relapsed/refractory inflammatory breast cancer (IBC): Clinical activity and biologic predictors of response

Journal of clinical oncology, 2006-06, Vol.24 (18_suppl), p.502-502

2006

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A safety, tolerability, and pharmacokinetic (PK) study of GW572016 in patients with solid tumors

Journal of clinical oncology, 2004-07, Vol.22 (14_suppl), p.3179-3179

2004

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A safety, tolerability, and pharmacokinetic (PK) study of GW572016 in patients with solid tumors

Journal of clinical oncology, 2004-07, Vol.22 (14_suppl), p.3179-3179

2004

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Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

Truncated ErbB2 receptor (p95 ) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR ErbB2 kinase inhibitor GW572016

Anti-B4-blocked ricin: a phase I trial of 7-day continuous infusion in patients with B-cell neoplasms

28-kDa Mammalian Heat Shock Protein, a Novel Substrate of a Growth Regulatory Protease Involved in Differentiation of Human Leukemia Cells (∗)

Heat shock protein is a unique marker of growth arrest during macrophage differentiation of HL-60 cells

Abstract PL2-1: Drug Development — Targeting HER2 beyond Trastuzumab

Growth arrest of human B lymphocytes is accompanied by induction of the low molecular weight mammalian heat shock protein (Hsp28)

A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53

Regulation of the 28 kDa heat shock protein by retinoic acid during differentiation of human leukemic HL-60 cells

Phase I Safety, Pharmacokinetics, and Clinical Activity Study of Lapatinib (GW572016), a Reversible Dual Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinases, in Heavily Pretreated Patients With Metastatic Carcinomas

Sensitization of tumor cells to Fas killing through overexpression of heat-shock transcription factor 1

Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies

Truncation of Sp1 transcription factor by myeloblastin in undifferentiated HL60 cells

Activation primes human B lymphocytes to respond to heat shock

Regulation of survivin by ErbB2 signaling : Therapeutic implications for ErbB2-overexpressing breast cancers

A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon

Tumor Selective G2/M Cell Cycle Arrest and Apoptosis of Epithelial and Hematological Malignancies by BBL22, a Benzazepine

Abstract P4-08-03: The impact of the heregulin-HER receptor signaling axis on response to HER tyrosine kinase inhibitors

Activation of the AMPK regulated metabolic stress response by a small molecule HER2/EGFR tyrosine kinase inhibitor protects cardiac myocytes from apoptotic stimuli

Activation signals regulate heat shock transcription factor 1 in human B lymphocytes

Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects

EGF103009, a phase II trial of lapatinib monotherapy in patients with relapsed/refractory inflammatory breast cancer (IBC): Clinical activity and biologic predictors of response

A safety, tolerability, and pharmacokinetic (PK) study of GW572016 in patients with solid tumors

A safety, tolerability, and pharmacokinetic (PK) study of GW572016 in patients with solid tumors

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