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Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation

Bioscience reports, 2014-08, Vol.34 (4), p.e00133

2014

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SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D 2 Receptor Mechanism of Action

The Journal of pharmacology and experimental therapeutics, 2019-10, Vol.371 (1), p.1-14

2019

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Structural, Kinetic, and Pharmacodynamic Mechanisms of d‑Amino Acid Oxidase Inhibition by Small Molecules

Journal of medicinal chemistry, 2013-05, Vol.56 (9), p.3710-3724

2013

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Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain

The Journal of pharmacology and experimental therapeutics, 2013-06, Vol.345 (3), p.502-511

2013

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Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors

Bioorganic & medicinal chemistry, 2011-01, Vol.19 (1), p.663-676

2011

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Effects of D‐amino acid oxidase inhibition on memory performance and long‐term potentiation in vivo

Pharmacology research & perspectives, 2013-10, Vol.1 (1), p.e00007-n/a

2013

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The evolution of library design: crafting smart compound collections for phenotypic screens

Drug discovery today. Technologies, 2017-03, Vol.23, p.61-67

2017

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Synthesis and Pharmacological Characterization of Bicyclic Triple Reuptake Inhibitor 3-Aryl Octahydrocyclopenta[c]pyrrole Analogues

Journal of medicinal chemistry, 2011-08, Vol.54 (15), p.5283-5295

2011

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Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (5), p.1438-1441

2011

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Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.520-523

2011

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Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (11), p.3063-3066

2009

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Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (5), p.1434-1437

2011

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Application of the sulfonamide functional group as an anchor for solid phase organic synthesis (SPOS)

Tetrahedron letters, 1996-02, Vol.37 (8), p.1145-1148

1996

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In vivo phenotypic drug discovery: applying a behavioral assay to the discovery and optimization of novel antipsychotic agents

MedChemComm, 2016-01, Vol.7 (6), p.1093-1101

2016

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In vivo phenotypic drug discovery: applying a behavioral assay to the discovery and optimization of novel antipsychotic agentsThe authors declare no competing interests.Electronic supplementary information (ESI) available: Supplementary data associated with this article can be found in the online version. See DOI: 10.1039/c6md00128a

2016-06

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In vivophenotypic drug discovery: applying a behavioral assay to the discovery and optimization of novel antipsychotic agents

MedChemComm, 2016-06, Vol.7 (6), p.1093-1101

2016

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Conformational restriction of angiotensin II: cyclic analogs having high potency

Journal of medicinal chemistry, 1990-07, Vol.33 (7), p.1935-1940

1990

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Thiorphan, an Inhibitor of Endopeptidase 24.11, Potentiates the Natriuretic Activity of Atrial Natriuretic Peptide

Journal of cardiovascular pharmacology, 1989-09, Vol.14 (3), p.419-424

1989

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A thioamide substrate of carboxypeptidase A

Biochemistry (Easton), 1982-03, Vol.21 (7), p.1608-1611

1982

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Analogs of atriopeptin(103-125)amide having high binding selectivity

Journal of medicinal chemistry, 1989-05, Vol.32 (5), p.1094-1098

1989

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Conformationally restricted analogs of atriopeptin(103-125) amide

Journal of medicinal chemistry, 1989-01, Vol.32 (1), p.67-72

1989

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Retrospective Analysis of an Experimental High-Throughput Screening Data Set by Recursive Partitioning

Journal of combinatorial chemistry, 2001-05, Vol.3 (3), p.267-277

2001

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Solid phase organic synthesis (SPOS): a novel route to diketopiperazines and diketomorpholines

Molecular diversity, 1996-02, Vol.1 (2), p.125-134

1996

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Inactivation of atrial natriuretic factor by the renal brush border

Biochimica et biophysica acta, 1987-07, Vol.901 (1), p.97-100

1987

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Specific inhibitors of endopeptidase 24.11 inhibit the metabolism of atrial natriuretic peptides in vitro and in vivo

Molecular and cellular endocrinology, 1989-02, Vol.61 (2), p.201-208

1989

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Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation

SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D 2 Receptor Mechanism of Action

Structural, Kinetic, and Pharmacodynamic Mechanisms of d‑Amino Acid Oxidase Inhibition by Small Molecules

Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain

Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors

Effects of D‐amino acid oxidase inhibition on memory performance and long‐term potentiation in vivo

The evolution of library design: crafting smart compound collections for phenotypic screens

Synthesis and Pharmacological Characterization of Bicyclic Triple Reuptake Inhibitor 3-Aryl Octahydrocyclopenta[c]pyrrole Analogues

Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor

Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor

Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel

Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor

Application of the sulfonamide functional group as an anchor for solid phase organic synthesis (SPOS)

In vivo phenotypic drug discovery: applying a behavioral assay to the discovery and optimization of novel antipsychotic agents

In vivophenotypic drug discovery: applying a behavioral assay to the discovery and optimization of novel antipsychotic agents

Conformational restriction of angiotensin II: cyclic analogs having high potency

Thiorphan, an Inhibitor of Endopeptidase 24.11, Potentiates the Natriuretic Activity of Atrial Natriuretic Peptide

A thioamide substrate of carboxypeptidase A

Analogs of atriopeptin(103-125)amide having high binding selectivity

Conformationally restricted analogs of atriopeptin(103-125) amide

Retrospective Analysis of an Experimental High-Throughput Screening Data Set by Recursive Partitioning

Solid phase organic synthesis (SPOS): a novel route to diketopiperazines and diketomorpholines

Inactivation of atrial natriuretic factor by the renal brush border

Specific inhibitors of endopeptidase 24.11 inhibit the metabolism of atrial natriuretic peptides in vitro and in vivo

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