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Discovery and Development of α7 Nicotinic Acetylcholine Receptor Modulators

Journal of medicinal chemistry, 2011-12, Vol.54 (23), p.7943-7961

2011

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3D Molecular Descriptors Important for Clinical Success

Journal of chemical information and modeling, 2013-02, Vol.53 (2), p.327-342

2013

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Systemic Administration of an Alpha-7 Nicotinic Acetylcholine Agonist Reverses Neuropathic Pain in Male Sprague Dawley Rats

The journal of pain, 2012-12, Vol.13 (12), p.1162-1171

2012

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Discovery of 3‑(5-Chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a Novel Highly Selective α4β2 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9181-9194

2012

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Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: Correlation with desensitization of α4β2 receptors

European journal of pharmaceutical sciences, 2012-12, Vol.47 (5), p.813-823

2012

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Tetrahydroquinoline derivatives as opioid receptor antagonists

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (2), p.670-676

2011

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Lysosomes contribute to anomalous pharmacokinetic behavior of melanocortin-4 receptor agonists

Pharmaceutical research, 2007-06, Vol.24 (6), p.1138-1144

2007

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DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.16159-16176

2021

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Novel benzimidazole-based MCH R1 antagonists

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (19), p.4994-5000

2006

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Recent advances in the development of melanocortin-4 receptor agonists

Expert opinion on therapeutic patents, 2002-11, Vol.12 (11), p.1631-1638

2002

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α1-Adrenoceptor agonists: The identification of novel α1A Subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.471-475

2002

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Synthetic Studies on Quassinoids: Total Synthesis and Biological Evaluation of (+)-Des-d-chaparrinone

Journal of organic chemistry, 1998-08, Vol.63 (17), p.5929-5936

1998

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2-(anilinomethyl)imidazolines as α1 adrenergic receptor agonists : α1a subtype selective 2'-heteroaryl compounds

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1183-1186

2003

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Regulation of Ingestive Behaviors in the Rat by GSK1521498, a Novel μ-Opioid Receptor-Selective Inverse Agonist

The Journal of pharmacology and experimental therapeutics, 2011-10, Vol.339 (1), p.24-34

2011

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2-(Anilinomethyl)imidazolines as α1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.575-579

2002

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Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the α4β2 and α6/α3β2β3 nicotinic acetylcholine receptors (nAChRs)

European journal of medicinal chemistry, 2014-10, Vol.86, p.60-74

2014

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α1-Adrenoceptor activation: A comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines

Bioorganic & medicinal chemistry letters, 2002-12, Vol.12 (23), p.3449-3452

2002

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Studies directed toward the total synthesis of scytophycin C: Synthesis of the C(1)C(18) fragment of scytophycin C

Tetrahedron letters, 1998-03, Vol.39 (11), p.1275-1278

1998

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Discovery of novel alpha 7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1179-1186

2012

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2-(Anilinomethyl)imidazolines as α1 Adrenergic Receptor Agonists: the Discovery of α1 a Subtype Selective 2‘-Alkylsulfonyl-Substituted Analogues

Journal of medicinal chemistry, 2002-05, Vol.45 (11), p.2229-2239

2002

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Discovery of novel α7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1179-1186

2012

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Regulation of ingestive behaviors in the rat by GSK1521498, a novel micro-opioid receptor-selective inverse agonist

The Journal of pharmacology and experimental therapeutics, 2011-10, Vol.339 (1), p.24

2011

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alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.471-475

2002

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Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines

Bioorganic & medicinal chemistry letters, 2002-12, Vol.12 (23), p.3449-3452

2002

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Synthesis of the C(19)C(32) fragment of scytophycin C via stereospecific methylation of γ,δ-epoxy acrylates with trimethylaluminum

Tetrahedron letters, 1998-03, Vol.39 (10), p.1125-1128

1998

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Discovery and Development of α7 Nicotinic Acetylcholine Receptor Modulators

3D Molecular Descriptors Important for Clinical Success

Systemic Administration of an Alpha-7 Nicotinic Acetylcholine Agonist Reverses Neuropathic Pain in Male Sprague Dawley Rats

Discovery of 3‑(5-Chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a Novel Highly Selective α4β2 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders

Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: Correlation with desensitization of α4β2 receptors

Tetrahydroquinoline derivatives as opioid receptor antagonists

Lysosomes contribute to anomalous pharmacokinetic behavior of melanocortin-4 receptor agonists

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Novel benzimidazole-based MCH R1 antagonists

Recent advances in the development of melanocortin-4 receptor agonists

α1-Adrenoceptor agonists: The identification of novel α1A Subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines

Synthetic Studies on Quassinoids: Total Synthesis and Biological Evaluation of (+)-Des-d-chaparrinone

2-(anilinomethyl)imidazolines as α1 adrenergic receptor agonists : α1a subtype selective 2'-heteroaryl compounds

Regulation of Ingestive Behaviors in the Rat by GSK1521498, a Novel μ-Opioid Receptor-Selective Inverse Agonist

2-(Anilinomethyl)imidazolines as α1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series

Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the α4β2 and α6/α3β2β3 nicotinic acetylcholine receptors (nAChRs)

α1-Adrenoceptor activation: A comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines

Studies directed toward the total synthesis of scytophycin C: Synthesis of the C(1)C(18) fragment of scytophycin C

Discovery of novel alpha 7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs

2-(Anilinomethyl)imidazolines as α1 Adrenergic Receptor Agonists: the Discovery of α1 a Subtype Selective 2‘-Alkylsulfonyl-Substituted Analogues

Discovery of novel α7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs

Regulation of ingestive behaviors in the rat by GSK1521498, a novel micro-opioid receptor-selective inverse agonist

alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines

Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines

Synthesis of the C(19)C(32) fragment of scytophycin C via stereospecific methylation of γ,δ-epoxy acrylates with trimethylaluminum

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