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Intestinal drug efflux: formulation and food effects

Advanced drug delivery reviews, 2001-10, Vol.50, p.S13-S31

2001

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Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug

Advanced drug delivery reviews, 2007-07, Vol.59 (6), p.419-426

2007

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Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol

European Journal of Pharmaceutical Sciences, 2001-02, Vol.12 (4), p.361-367

2001

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Rate-limiting biotransformation of triamterene is mediated by CYP1A2

International journal of clinical pharmacology and therapeutics, 2005-07, Vol.43 (7), p.327-334

2005

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Nanosuspension formulations for low-soluble drugs : Pharmacokinetic evaluation using spironolactone as model compound

Drug development and industrial pharmacy, 2005-03, Vol.31 (3), p.319-329

2005

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Acyl glucuronides revisited : is the glucuronidation process a toxification as well as a detoxification mechanism ?

Drug metabolism reviews, 1992, Vol.24 (1), p.5-47

1992

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Concentration-Dependent Effect of Naringin on Intestinal Absorption of β₁-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp)

Pharmaceutical research, 2009-03, Vol.26 (3), p.560-567

2009

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Caco‐2 versus Caco‐2/HT29‐MTX Co‐cultured Cell Lines: Permeabilities Via Diffusion, Inside‐ and Outside‐Directed Carrier‐Mediated Transport

Journal of pharmaceutical sciences, 2000-01, Vol.89 (1), p.63-75

2000

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P-glycoprotein transporters and the gastrointestinal tract: evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound

International journal of clinical pharmacology and therapeutics, 1998-01, Vol.36 (1), p.16

1998

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Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds - implications for pharmacokinetics of selected substrates

Journal of pharmacy and pharmacology, 2004-08, Vol.56 (8), p.967-975

2004

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In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect

Pharmaceutical research, 2006-08, Vol.23 (8), p.1712-1720

2006

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Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT?

European journal of pharmaceutical sciences, 2005-06, Vol.25 (2), p.263-271

2005

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Comparative Pharmacodynamics and Pharmacokinetics of Candesartan and Losartan in Man

Journal of pharmacy and pharmacology, 2000-09, Vol.52 (9), p.1075-1083

2000

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Affinities at the verapamil binding site of MDR1-encoded P-glycoprotein: drugs and analogs, stereoisomers and metabolites

International journal of clinical pharmacology and therapeutics, 2000-04, Vol.38 (4), p.168-179

2000

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P-Glycoprotein (P-gp) Mediated Efflux in Caco-2 Cell Monolayers: The Influence of Culturing Conditions and Drug Exposure on P-gp Expression Levels

Journal of pharmaceutical sciences, 1998-06, Vol.87 (6), p.757-762

1998

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Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells

Planta medica, 2007-01, Vol.73 (1), p.27-32

2007

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Role of P-glycoprotein-mediated secretion in absorptive drug permeability : An approach using passive membrane permeability and affinity to P-glycoprotein

Journal of pharmaceutical sciences, 1999-10, Vol.88 (10), p.1067-1072

1999

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Dimeric 4-aryl-1,4-dihydropyridines as novel HIV-1 protease inhibitors : affinities to intestinal P-glycoprotein

Pharmazie, 2000-10, Vol.55 (10), p.784-785

2000

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The influence of age on the pharmacokinetics and pharmacodynamics of bemetizide and triamterene: a single and multiple dose study

Archives of gerontology and geriatrics, 2001-06, Vol.32 (3), p.265-273

2001

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Covalent binding of acidic drugs via reactive intermediates : detection of benoxaprofen and flunoxaprofen protein adducts in biological material

Pharmazie, 1996-11, Vol.51 (11), p.874-881

1996

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Saturable Enantioselective First-pass Effect for Carvedilol after High Oral Racemate Doses in Rats

Archiv der Pharmazie (Weinheim), 1993, Vol.326 (3), p.123-125

1993

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Lipophilicities of baclofen ester prodrugs correlate with affinities to the ATP-dependent efflux pump P-glycoprotein: Relevance for their permeation across the blood-brain barrier?

Pharmaceutical research, 2003-05, Vol.20 (5), p.772-778

2003

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In vivo non-linear intestinal permeability of celiprolol and propranolol in conscious dogs: evidence for intestinal secretion

European journal of pharmaceutical sciences, 1998, Vol.6 (1), p.75-81

1998

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Pretreatment with potent P-glycoprotein ligands may increase intestinal secretion in rats

European journal of pharmaceutical sciences, 2001-02, Vol.12 (4), p.405-415

2001

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HPLC assays to simultaneously determine the angiotensin-AT1 antagonist losartan as well as its main and active metabolite EXP 3174 in biological material of humans and rats

Journal of pharmaceutical and biomedical analysis, 1998, Vol.16 (5), p.863-873

1998

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Intestinal drug efflux: formulation and food effects

Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug

Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol

Rate-limiting biotransformation of triamterene is mediated by CYP1A2

Nanosuspension formulations for low-soluble drugs : Pharmacokinetic evaluation using spironolactone as model compound

Acyl glucuronides revisited : is the glucuronidation process a toxification as well as a detoxification mechanism ?

Concentration-Dependent Effect of Naringin on Intestinal Absorption of β₁-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp)

Caco‐2 versus Caco‐2/HT29‐MTX Co‐cultured Cell Lines: Permeabilities Via Diffusion, Inside‐ and Outside‐Directed Carrier‐Mediated Transport

P-glycoprotein transporters and the gastrointestinal tract: evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound

Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds - implications for pharmacokinetics of selected substrates

In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect

Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT?

Comparative Pharmacodynamics and Pharmacokinetics of Candesartan and Losartan in Man

Affinities at the verapamil binding site of MDR1-encoded P-glycoprotein: drugs and analogs, stereoisomers and metabolites

P-Glycoprotein (P-gp) Mediated Efflux in Caco-2 Cell Monolayers: The Influence of Culturing Conditions and Drug Exposure on P-gp Expression Levels

Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells

Role of P-glycoprotein-mediated secretion in absorptive drug permeability : An approach using passive membrane permeability and affinity to P-glycoprotein

Dimeric 4-aryl-1,4-dihydropyridines as novel HIV-1 protease inhibitors : affinities to intestinal P-glycoprotein

The influence of age on the pharmacokinetics and pharmacodynamics of bemetizide and triamterene: a single and multiple dose study

Covalent binding of acidic drugs via reactive intermediates : detection of benoxaprofen and flunoxaprofen protein adducts in biological material

Saturable Enantioselective First-pass Effect for Carvedilol after High Oral Racemate Doses in Rats

Lipophilicities of baclofen ester prodrugs correlate with affinities to the ATP-dependent efflux pump P-glycoprotein: Relevance for their permeation across the blood-brain barrier?

In vivo non-linear intestinal permeability of celiprolol and propranolol in conscious dogs: evidence for intestinal secretion

Pretreatment with potent P-glycoprotein ligands may increase intestinal secretion in rats

HPLC assays to simultaneously determine the angiotensin-AT1 antagonist losartan as well as its main and active metabolite EXP 3174 in biological material of humans and rats

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