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Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension

Hepatology (Baltimore, Md.), 2019-02, Vol.69 (2), p.717-728

2019

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Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo

Clinical gastroenterology and hepatology, 2019-03, Vol.17 (4), p.774-783.e4

2019

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Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo

Toxicological sciences, 2018-04, Vol.162 (2), p.396-405

2018

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Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte‐Mediated Paracrine Mechanism

Hepatology communications, 2019-07, Vol.3 (7), p.987-1000

2019

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Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor

Bioorganic & medicinal chemistry letters, 2003-09, Vol.13 (18), p.3097-3100

2003

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A New Series of PDGF Receptor Tyrosine Kinase Inhibitors: 3-Substituted Quinoline Derivatives

Journal of medicinal chemistry, 1994-07, Vol.37 (14), p.2129-2137

1994

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Molecular Structures of Human Factor Xa Complexed with Ketopiperazine Inhibitors: Preference for a Neutral Group in the S1 Pocket

Journal of medicinal chemistry, 2003-02, Vol.46 (5), p.685-690

2003

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Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors

Journal of medicinal chemistry, 2000-08, Vol.43 (17), p.3226-3232

2000

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Structural and Functional Analysis of Caspase Active Sites

Biochemistry (Easton), 2003-04, Vol.42 (14), p.4151-4160

2003

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A Nucleotide Binding Site in Caspase-9 Regulates Apoptosome Activation

Biochemistry (Easton), 2005-04, Vol.44 (13), p.4971-4976

2005

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Caspases and therapeutic potential of caspase inhibitors in moderate–severe SARS‐CoV‐2 infection and long COVID

Allergy (Copenhagen), 2022-01, Vol.77 (1), p.118-129

2022

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Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR Exploration and Effective Bioisosteric Replacement of a phenyl substituent

Bioorganic & medicinal chemistry letters, 2003-09, Vol.13 (18), p.3091-3095

2003

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Restenosis following angioplasty in the swine coronary artery is inhibited by an orally active PDGF-receptor tyrosine kinase inhibitor, RPR101511A

Circulation (New York, N.Y.), 1999-06, Vol.99 (25), p.3292-3299

1999

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Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity

Bioorganic & medicinal chemistry letters, 2002-06, Vol.12 (12), p.1671-1674

2002

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Conformational restrictions in the active site of unliganded human caspase-3

Journal of molecular recognition, 2003-05, Vol.16 (3), p.121-124

2003

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A Placebo-Controlled, Multicenter, Double-Blind, Phase 2 Randomized Trial of the Pan-Caspase Inhibitor Emricasan in Patients with Acutely Decompensated Cirrhosis

Journal of clinical and experimental hepatology, 2018-09, Vol.8 (3), p.224-234

2018

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RPR120844, a novel, specific inhibitor of coagulation factor Xa inhibits venous thrombosis in the rabbit

Thrombosis and haemostasis, 1999-01, Vol.81 (1), p.157-160

1999

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The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice

Cancer research (Chicago, Ill.), 1991-08, Vol.51 (16), p.4430-4435

1991

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Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.437-450

1998

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Optimization of the β-aminoester class of factor Xa inhibitors. Part 1: P4 and side-chain modifications for improved in vitro potency

Bioorganic & medicinal chemistry letters, 2002-06, Vol.12 (12), p.1667-1670

2002

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In Vitro Characterization of a Novel Factor Xa Inhibitor, RPR 130737

Thrombosis research, 2000-07, Vol.99 (1), p.71-82

2000

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Nonbenzamidine compounds as selective factor xa inhibitors

Bioorganic & medicinal chemistry letters, 2000-08, Vol.10 (15), p.1737-1739

2000

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Two opportunities to shape your future

Modern Casting, 2011-05, Vol.101 (5), p.7-7

Spada, Alfred T

2011

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Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors

Bioorganic & medicinal chemistry letters, 2002-03, Vol.12 (6), p.919-922

2002

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Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension

Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo

Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo

Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte‐Mediated Paracrine Mechanism

Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor

A New Series of PDGF Receptor Tyrosine Kinase Inhibitors: 3-Substituted Quinoline Derivatives

Molecular Structures of Human Factor Xa Complexed with Ketopiperazine Inhibitors: Preference for a Neutral Group in the S1 Pocket

Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors

Structural and Functional Analysis of Caspase Active Sites

A Nucleotide Binding Site in Caspase-9 Regulates Apoptosome Activation

Caspases and therapeutic potential of caspase inhibitors in moderate–severe SARS‐CoV‐2 infection and long COVID

Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR Exploration and Effective Bioisosteric Replacement of a phenyl substituent

Restenosis following angioplasty in the swine coronary artery is inhibited by an orally active PDGF-receptor tyrosine kinase inhibitor, RPR101511A

Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity

Conformational restrictions in the active site of unliganded human caspase-3

A Placebo-Controlled, Multicenter, Double-Blind, Phase 2 Randomized Trial of the Pan-Caspase Inhibitor Emricasan in Patients with Acutely Decompensated Cirrhosis

RPR120844, a novel, specific inhibitor of coagulation factor Xa inhibits venous thrombosis in the rabbit

The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice

Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa

Optimization of the β-aminoester class of factor Xa inhibitors. Part 1: P4 and side-chain modifications for improved in vitro potency

In Vitro Characterization of a Novel Factor Xa Inhibitor, RPR 130737

Nonbenzamidine compounds as selective factor xa inhibitors

Two opportunities to shape your future

Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors

First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease

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