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Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents

The Journal of biological chemistry, 2003-06, Vol.278 (24), p.21767-21773

2003

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Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase–activated protein kinase 2 in mediating DNA damage–induced cell cycle arrest: implications for cancer therapy

Molecular cancer therapeutics, 2006-08, Vol.5 (8), p.1935-1943

2006

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Selective Chk1 inhibitors differentially sensitize p53‐deficient cancer cells to cancer therapeutics

International journal of cancer, 2006-12, Vol.119 (12), p.2784-2794

2006

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A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

Oncogene, 2005-02, Vol.24 (8), p.1403-1411

2005

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Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6621-6636

2009

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Isoxazolo[3,4- b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (19), p.5206-5208

2008

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Structure-Based Design, Synthesis, and Biological Evaluation of Potent and Selective Macrocyclic Checkpoint Kinase 1 Inhibitors

Journal of medicinal chemistry, 2007-04, Vol.50 (7), p.1514-1527

2007

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Human Chk1 Expression Is Dispensable for Somatic Cell Death and Critical for Sustaining G2 DNA Damage Checkpoint

Molecular cancer therapeutics, 2003-06, Vol.2 (6), p.543-548

2003

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Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

Journal of medicinal chemistry, 2007-08, Vol.50 (17), p.4162-4176

2007

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Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics

International journal of cancer, 2005-07, Vol.115 (4), p.528-538

2005

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Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores

Journal of medicinal chemistry, 2001-04, Vol.44 (8), p.1192-1201

2001

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Synthesis of Substituted Quinolines Using the Dianion Addition of N-Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones

Journal of organic chemistry, 2002-12, Vol.67 (26), p.9182-9185

2002

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Discovery of 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5944-5951

2007

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Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4308-4315

2007

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Discovery of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors

Bioorganic & medicinal chemistry, 2007-04, Vol.15 (7), p.2759-2767

2007

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Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors

Biomarkers, 2008-01, Vol.13 (6), p.579-596

2008

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Synthesis of Macrocyclic Urea Kinase Inhibitors

Synlett, 2007-11, Vol.2007 (18), p.2855-2858

2007

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Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (8), p.2293-2298

2006

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Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[ b, e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (7), p.2311-2315

2008

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Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2- c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (11), p.3136-3140

2007

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Hit-to-lead optimization of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of KDR kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4371-4375

2006

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1,4-Dihydroindeno[1,2- c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4266-4271

2006

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1,4-Dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (13), p.3618-3623

2007

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Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5665-5670

2007

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Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents

Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase–activated protein kinase 2 in mediating DNA damage–induced cell cycle arrest: implications for cancer therapy

Selective Chk1 inhibitors differentially sensitize p53‐deficient cancer cells to cancer therapeutics

A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Isoxazolo[3,4- b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

Structure-Based Design, Synthesis, and Biological Evaluation of Potent and Selective Macrocyclic Checkpoint Kinase 1 Inhibitors

Human Chk1 Expression Is Dispensable for Somatic Cell Death and Critical for Sustaining G2 DNA Damage Checkpoint

Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics

Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores

Synthesis of Substituted Quinolines Using the Dianion Addition of N-Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones

Discovery of 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors

Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

Discovery of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors

Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors

Synthesis of Macrocyclic Urea Kinase Inhibitors

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[ b, e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2- c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

Hit-to-lead optimization of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of KDR kinase inhibitors

1,4-Dihydroindeno[1,2- c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors

1,4-Dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies

Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

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