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A Novel Dual-Function Redox Modulator Relieves Oxidative Stress and Anti-Angiogenic Response in Placental Villus Explant Exposed to Hypoxia—Relevance for Preeclampsia Therapy

Biology (Basel, Switzerland), 2023-09, Vol.12 (9), p.1229

2023

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Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

Nature medicine, 2001-01, Vol.7 (1), p.108-113

2001

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A Novel Dual-Function Nitric Oxide Donor Therapy for Preeclampsia-A Proof-of-Principle Study in a Murine Model

Antioxidants, 2023-11, Vol.12 (12), p.2036

2023

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Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock

The Journal of immunology (1950), 2000-01, Vol.164 (2), p.1013-1019

2000

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Novel phenanthridinone inhibitors of poly(adenosine 5′-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents

Critical care medicine, 2002-05, Vol.30 (5), p.1071-1082

2002

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Discovery of Potent Poly(ADP-ribose) Polymerase-1 Inhibitors from the Modification of Indeno[1,2-c]isoquinolinone

Journal of medicinal chemistry, 2005-08, Vol.48 (16), p.5100-5103

2005

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Poly(ADP-ribose) polymerase inhibitors

Current medicinal chemistry, 2003-02, Vol.10 (4), p.321-340

2003

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The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.81-85

2004

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The peroxynitrite catalyst WW-85 improves pulmonary function in ovine septic shock

Shock (Augusta, Ga.), 2011-02, Vol.35 (2), p.148-155

2011

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The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes

Journal of endocrinology, 2008-09, Vol.198 (3), p.581-589

2008

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Beneficial Effects and Improved Survival in Rodent Models of Septic Shock with S-Methylisothiourea Sulfate, a Potent and Selective Inhibitor of Inducible Nitric Oxide Synthase

Proceedings of the National Academy of Sciences - PNAS, 1994-12, Vol.91 (26), p.12472-12476

1994

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Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys

Kidney international, 2000-07, Vol.58 (1), p.82-89

2000

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Poly(ADP-Ribose) Polymerase Inhibition Reduces Reperfusion Injury After Heart Transplantation

Circulation research, 2002-01, Vol.90 (1), p.100-106

2002

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Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke

International journal of molecular medicine, 2004-03, Vol.13 (3), p.373

2004

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Synthesis of (R)-3,4-dihydro-2H-pyran-2-carboxaldehyde: application to the synthesis of potent adenosine A(2A) and A(3) receptor agonist

Tetrahedron letters, 2009-06, Vol.50 (22), p.2693-2696

2009

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Conversion of Proteins to Diazeniumdiolate-Based Nitric Oxide Donors

Bioconjugate chemistry, 1999-09, Vol.10 (5), p.838-842

1999

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Mercaptoethylguanidine and Guanidine Inhibitors of Nitric-oxide Synthase React with Peroxynitrite and Protect against Peroxynitrite-induced Oxidative Damage

The Journal of biological chemistry, 1997-04, Vol.272 (14), p.9030-9036

1997

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The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury

Shock (Augusta, Ga.), 2009-09, Vol.32 (3), p.258-262

2009

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Localizing Antithrombotic and Vasodilatory Activity with a Novel, Ultrafast Nitric Oxide Donor

Journal of medicinal chemistry, 1996-10, Vol.39 (22), p.4361-4365

1996

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Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis

Molecular medicine (Cambridge, Mass.), 2002-10, Vol.8 (10), p.581-590

2002

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Inhibition of Experimental Gingivitis in Beagle Dogs With Topical Mercaptoalkylguanidines

Journal of periodontology (1970), 2006-03, Vol.77 (3), p.385-391

2006

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Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

Biochemical pharmacology, 1996-02, Vol.51 (4), p.383-394

1996

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The inhibitory effects of mercaptoalkylguanidines on cyclo‐oxygenase activity

British journal of pharmacology, 1997-02, Vol.120 (3), p.357-366

1997

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Mitogen-activated protein kinase phosphorylation in kidneys of beta(s) sickle cell mice

Journal of the American Society of Nephrology, 2000-06, Vol.11 (6), p.1026-1032

2000

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Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: requirement of a serum factor

British journal of pharmacology, 1994-06, Vol.112 (2), p.355-356

1994

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A Novel Dual-Function Redox Modulator Relieves Oxidative Stress and Anti-Angiogenic Response in Placental Villus Explant Exposed to Hypoxia—Relevance for Preeclampsia Therapy

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

A Novel Dual-Function Nitric Oxide Donor Therapy for Preeclampsia-A Proof-of-Principle Study in a Murine Model

Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock

Novel phenanthridinone inhibitors of poly(adenosine 5′-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents

Discovery of Potent Poly(ADP-ribose) Polymerase-1 Inhibitors from the Modification of Indeno[1,2-c]isoquinolinone

Poly(ADP-ribose) polymerase inhibitors

The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)

The peroxynitrite catalyst WW-85 improves pulmonary function in ovine septic shock

The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes

Beneficial Effects and Improved Survival in Rodent Models of Septic Shock with S-Methylisothiourea Sulfate, a Potent and Selective Inhibitor of Inducible Nitric Oxide Synthase

Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys

Poly(ADP-Ribose) Polymerase Inhibition Reduces Reperfusion Injury After Heart Transplantation

Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke

Synthesis of (R)-3,4-dihydro-2H-pyran-2-carboxaldehyde: application to the synthesis of potent adenosine A(2A) and A(3) receptor agonist

Conversion of Proteins to Diazeniumdiolate-Based Nitric Oxide Donors

Mercaptoethylguanidine and Guanidine Inhibitors of Nitric-oxide Synthase React with Peroxynitrite and Protect against Peroxynitrite-induced Oxidative Damage

The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury

Localizing Antithrombotic and Vasodilatory Activity with a Novel, Ultrafast Nitric Oxide Donor

Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis

Inhibition of Experimental Gingivitis in Beagle Dogs With Topical Mercaptoalkylguanidines

Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

The inhibitory effects of mercaptoalkylguanidines on cyclo‐oxygenase activity

Mitogen-activated protein kinase phosphorylation in kidneys of beta(s) sickle cell mice

Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: requirement of a serum factor

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