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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

Malaria journal, 2013-06, Vol.12 (1), p.212-212, Article 212

2013

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Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria

The New England journal of medicine, 2013-10, Vol.369 (14), p.1381-1382

2013

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CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

Malaria journal, 2012-08, Vol.11 (1), p.259-259, Article 259

2012

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A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation

The Journal of infectious diseases, 2018-02, Vol.217 (5), p.693-702

2018

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Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

Malaria journal, 2014-01, Vol.13 (1), p.2-2, Article 2

2014

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Differential CYP 2D6 metabolism alters primaquine pharmacokinetics

Antimicrobial agents and chemotherapy, 2015-04, Vol.59 (4), p.2380-2387

2015

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Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population

The Journal of infectious diseases, 2019-10, Vol.220 (11), p.1761-1770

2019

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8:00 A.M. - 9:30 A.M - SYMPOSIUM: DEVELOPMENT OF FENTANYL-TARGETED VACCINES TO DECREASE OVERDOSE FATALITIES: Grand Ballroom II

Drug and alcohol dependence, 2024-07, Vol.260

2024

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SYMPOSIUM: DEVELOPMENT OF FENTANYL-TARGETED VACCINES TO DECREASE OVERDOSE FATALITIES

Drug and alcohol dependence, 2024-07, Vol.260, p.110797, Article 110797

2024

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Response and recovery of endocrine, behavioral, and neuronal morphology outcomes after different traumatic stressor exposures in male rats

Psychoneuroendocrinology, 2021-11, Vol.133, p.105394-105394, Article 105394

2021

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Comparison of Anti-Xa Activity in Patients Receiving Apixaban or Rivaroxaban

The Annals of pharmacotherapy, 2018-03, Vol.52 (3), p.251-256

2018

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Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations

Journal of pharmacological and toxicological methods, 2014-09, Vol.70 (2), p.188-194

2014

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Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics

Antimicrobial agents and chemotherapy, 2015-07, Vol.59 (7), p.3864-3869

2015

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CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

Malaria journal, 2013-06, Vol.12 (1), p.214-214, Article 214

2013

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Prolonged Protection Provided by a Single Dose of Atovaquone-Proguanil for the Chemoprophylaxis of Plasmodium falciparum Malaria in a Human Challenge Model

Clinical infectious diseases, 2012-01, Vol.54 (2), p.232-239

2012

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Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly

JCI insight, 2021-12, Vol.6 (23)

2021

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Developmental differences in stress responding after repeated underwater trauma exposures in rats

Stress (Amsterdam, Netherlands), 2018-05, Vol.21 (3), p.267-273

2018

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Saccharomyces boulardii CNCM I-745 probiotic does not alter the pharmacokinetics of amoxicillin

Drug Metabolism and Personalized Therapy, 2020-03

2020

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What is your diagnosis: Liver nodules in a Turkey Poult

Veterinary clinical pathology, 2023-05, Vol.52 (S2), p.146-148

2023

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Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

Malaria journal, 2010-02, Vol.9 (1), p.51-51, Article 51

2010

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Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites

Malaria Research and Treatment, 2017, Vol.2017, p.7508291-10

2017

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The use of a prodrug approach to minimize potential CNS exposure of next generation quinoline methanols while maintaining efficacy in in vivo animal models

European journal of drug metabolism and pharmacokinetics, 2014-12, Vol.39 (4), p.231-236

2014

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Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Malaria journal, 2011-06, Vol.10 (1), p.150-150, Article 150

2011

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Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines

Drug metabolism and disposition, 2008-02, Vol.36 (2), p.380-385

2008

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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

Differential CYP 2D6 metabolism alters primaquine pharmacokinetics

Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population

8:00 A.M. - 9:30 A.M - SYMPOSIUM: DEVELOPMENT OF FENTANYL-TARGETED VACCINES TO DECREASE OVERDOSE FATALITIES: Grand Ballroom II

SYMPOSIUM: DEVELOPMENT OF FENTANYL-TARGETED VACCINES TO DECREASE OVERDOSE FATALITIES

Response and recovery of endocrine, behavioral, and neuronal morphology outcomes after different traumatic stressor exposures in male rats

Comparison of Anti-Xa Activity in Patients Receiving Apixaban or Rivaroxaban

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations

Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics

An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model

CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

Prolonged Protection Provided by a Single Dose of Atovaquone-Proguanil for the Chemoprophylaxis of Plasmodium falciparum Malaria in a Human Challenge Model

Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly

Developmental differences in stress responding after repeated underwater trauma exposures in rats

Saccharomyces boulardii CNCM I-745 probiotic does not alter the pharmacokinetics of amoxicillin

What is your diagnosis: Liver nodules in a Turkey Poult

Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites

The use of a prodrug approach to minimize potential CNS exposure of next generation quinoline methanols while maintaining efficacy in in vivo animal models

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines

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