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Discovery of 6‑(Fluoro-18 F)‑3-(1H‑pyrrolo[2,3‑c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4778-4789

2016

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MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Antimicrobial Agents and Chemotherapy, 2012-08, Vol.56 (8), p.4161-4167

2012

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Malignant bowel obstruction: individualized treatment near the end of life

Cleveland Clinic journal of medicine, 2011-03, Vol.78 (3), p.197-206

2011

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Structural insights into selective small molecule activation of PKG1α

Communications biology, 2023-07, Vol.6 (1), p.798-798, Article 798

2023

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GTP-Dependent Activation of Urease Apoprotein in Complex with the UreD, UreF, and UreG Accessory Proteins

Proceedings of the National Academy of Sciences - PNAS, 1999-09, Vol.96 (20), p.11140-11144

1999

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Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2275-2277

2004

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Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α

The Journal of biological chemistry, 2022-09, Vol.298 (9), p.102284-102284, Article 102284

2022

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Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α

Journal of medicinal chemistry, 2022-08, Vol.65 (15), p.10318-10340

2022

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Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α)

ACS medicinal chemistry letters, 2021-08, Vol.12 (8), p.1275-1282

2021

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Affinity Selection–Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor

ACS chemical biology, 2017-05, Vol.12 (5), p.1346-1352

2017

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Design and Synthesis of P2–P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1173-1178

2016

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Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP‑4 Inhibitors for the Treatment of Type 2 Diabetes

ACS medicinal chemistry letters, 2016-05, Vol.7 (5), p.498-501

2016

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Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors

Bioorganic & medicinal chemistry, 2016-11, Vol.24 (21), p.5534-5545

2016

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P1‐244: Comparing [3H]MK‐6240 and [3H]AV‐1451(T‐807) in in VITRO Binding Studies in Brain Tissues

Alzheimer's & dementia, 2016-07, Vol.12 (7S_Part_10), p.P500-P501

2016

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IC‐P‐199: Comparing [3H]MK‐6240 and [3H]AV‐1451(T‐807) In In vitro Binding Studies in Brain Tissues

Alzheimer's & dementia, 2016-07, Vol.12 (7S_Part_3), p.P144-P144

2016

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Preclinical Characterization of ^sup 18^F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

The Journal of nuclear medicine (1978), 2016-10, Vol.57 (10), p.1599

2016

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Preclinical Characterization of 18 F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

Journal of Nuclear Medicine, 2016-10, Vol.57 (10), p.1599-1606

2016

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Preclinical Characterization of super( 18)F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

The Journal of nuclear medicine (1978), 2016-10, Vol.57 (10), p.1599-1599

2016

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The Discovery of N‑((2H‑Tetrazol-5-yl)methyl)-4-((R)‑1-((5r,8R)‑8‑(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2601-2610

2014

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Diencephalic Storms From Leptomeningeal Metastases and Leukoencephalopathy: A Rare and Clinically Important Complication

American journal of hospice & palliative medicine, 2014-02, Vol.31 (1), p.98-100

2014

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Discovery and optimization of antibacterial AccC inhibitors

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6507-6514

2009

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Palliative Care Issues for Transfusion-Dependent Patients #359

Journal of palliative medicine, 2018-09, Vol.21 (9), p.1359-1360

2018

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COMPARING [3 H]MK-6240 AND [3 H]AV-1451(T-807) IN IN VITRO BINDING STUDIES IN BRAIN TISSUES

Alzheimer's & dementia, 2016-07, Vol.12 (7), p.P500-P501

2016

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Discovery of 6‑(Fluoro-18 F)‑3-(1H‑pyrrolo[2,3‑c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Malignant bowel obstruction: individualized treatment near the end of life

Structural insights into selective small molecule activation of PKG1α

GTP-Dependent Activation of Urease Apoprotein in Complex with the UreD, UreF, and UreG Accessory Proteins

Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum

Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α

Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α

Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α)

Affinity Selection–Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor

Design and Synthesis of P2–P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors

Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP‑4 Inhibitors for the Treatment of Type 2 Diabetes

Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors

P1‐244: Comparing [3H]MK‐6240 and [3H]AV‐1451(T‐807) in in VITRO Binding Studies in Brain Tissues

IC‐P‐199: Comparing [3H]MK‐6240 and [3H]AV‐1451(T‐807) In In vitro Binding Studies in Brain Tissues

Preclinical Characterization of ^sup 18^F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

Preclinical Characterization of 18 F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

Preclinical Characterization of super( 18)F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor

The Discovery of N‑((2H‑Tetrazol-5-yl)methyl)-4-((R)‑1-((5r,8R)‑8‑(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

Diencephalic Storms From Leptomeningeal Metastases and Leukoencephalopathy: A Rare and Clinically Important Complication

Discovery and optimization of antibacterial AccC inhibitors

Palliative Care Issues for Transfusion-Dependent Patients #359

P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation Hepatitis C Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325

COMPARING [3 H]MK-6240 AND [3 H]AV-1451(T-807) IN IN VITRO BINDING STUDIES IN BRAIN TISSUES

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