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Elevated Plasma Adiponectin in Humans with Genetically Defective Insulin Receptors

The journal of clinical endocrinology and metabolism, 2006-08, Vol.91 (8), p.3219-3223

2006

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Severe insulin resistance due to anti‐insulin antibodies: response to plasma exchange and immunosuppressive therapy

Diabetic medicine, 2009-01, Vol.26 (1), p.79-82

2009

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Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

Nature (London), 1999-12, Vol.402 (6764), p.880-883

1999

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

Nature (London), 1997-06, Vol.387 (6636), p.903-908

1997

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Functional characterization of a novel insulin receptor mutation contributing to Rabson-Mendenhall syndrome

Clinical endocrinology (Oxford), 2007-01, Vol.66 (1), p.21-26

2007

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Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling

Diabetologia, 2011-05, Vol.54 (5), p.1057-1065

2011

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Defect in Insulin-Like Growth Factor-1 Survival Mechanism in Atherosclerotic Plaque-Derived Vascular Smooth Muscle Cells Is Mediated by Reduced Surface Binding and Signaling

Circulation research, 2001-05, Vol.88 (9), p.895-902

2001

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Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors

Biochemical Society transactions, 2001-08, Vol.29 (Pt 4), p.513-525

2001

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Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

Biochemical journal, 1993-03, Vol.290 (2), p.419-426

1993

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IRS2 variants and syndromes of severe insulin resistance

Diabetologia, 2009-06, Vol.52 (6), p.1208-1211

2009

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Treatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies

The journal of clinical endocrinology and metabolism, 2010-08, Vol.95 (8), p.3641-3647

2010

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Successful treatment of Type B insulin resistance in a patient with otherwise quiescent systemic lupus erythematosus

Diabetic medicine, 2005-06, Vol.22 (6), p.814-815

2005

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Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene

Diabetologia, 2004-04, Vol.47 (4), p.753-756

2004

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Deletion of V335 from the L2 Domain of the Insulin Receptor Results in a Conformationally Abnormal Receptor That Is Unable to Bind Insulin and Causes Donohue’s Syndrome in a Human Subject

Endocrinology (Philadelphia), 2003-02, Vol.144 (2), p.631-637

2003

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Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants

The Journal of biological chemistry, 1993-01, Vol.268 (2), p.1087-1094

1993

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Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

Biochemical journal, 1989-10, Vol.263 (2), p.553-563

1989

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Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting

Biochemical journal, 1997-10, Vol.327 ( Pt 1) (1), p.209-215

1997

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A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity

The Journal of biological chemistry, 1992-06, Vol.267 (18), p.12955-12963

1992

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Hypoglycemia and resistance to ketoacidosis in a subject without functional insulin receptors

The journal of clinical endocrinology and metabolism, 2001-07, Vol.86 (7), p.3319-3326

2001

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Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

Biochemical journal, 1990-09, Vol.270 (2), p.383-390

1990

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Transdominant Inhibition of Tyrosine Kinase Activity in Mutant Insulin/ Insulin-Like Growth Factor I Hybrid Receptors

Proceedings of the National Academy of Sciences - PNAS, 1991-01, Vol.88 (1), p.214-218

1991

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Monoclonal Antibodies to the Insulin Receptor Mimic Metabolic Effects of Insulin but do not Stimulate Receptor Autophosphorylation in Transfected NIH 3T3 Fibroblasts

Proceedings of the National Academy of Sciences - PNAS, 1989-07, Vol.86 (14), p.5217-5221

1989

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Functional activation of mutant human insulin receptor by monoclonal antibody

The Lancet (British edition), 1996-06, Vol.347 (9015), p.1586-1590

1996

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Insulin-like growth factor (IGF)-I A- and B-domain analogues with altered type 1 IGF and insulin receptor binding specificities

Journal of molecular endocrinology, 1996-12, Vol.17 (3), p.237-246

1996

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A monoclonal anti-peptide antibody reacting with the insulin receptor β-subunit : characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptors

Biochemical journal, 1992-11, Vol.288 (1), p.195-205

1992

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Elevated Plasma Adiponectin in Humans with Genetically Defective Insulin Receptors

Severe insulin resistance due to anti‐insulin antibodies: response to plasma exchange and immunosuppressive therapy

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

Congenital leptin deficiency is associated with severe early-onset obesity in humans

Functional characterization of a novel insulin receptor mutation contributing to Rabson-Mendenhall syndrome

Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling

Defect in Insulin-Like Growth Factor-1 Survival Mechanism in Atherosclerotic Plaque-Derived Vascular Smooth Muscle Cells Is Mediated by Reduced Surface Binding and Signaling

Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

IRS2 variants and syndromes of severe insulin resistance

Treatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies

Successful treatment of Type B insulin resistance in a patient with otherwise quiescent systemic lupus erythematosus

Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene

Deletion of V335 from the L2 Domain of the Insulin Receptor Results in a Conformationally Abnormal Receptor That Is Unable to Bind Insulin and Causes Donohue’s Syndrome in a Human Subject

Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants

Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting

A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity

Hypoglycemia and resistance to ketoacidosis in a subject without functional insulin receptors

Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

Transdominant Inhibition of Tyrosine Kinase Activity in Mutant Insulin/ Insulin-Like Growth Factor I Hybrid Receptors

Monoclonal Antibodies to the Insulin Receptor Mimic Metabolic Effects of Insulin but do not Stimulate Receptor Autophosphorylation in Transfected NIH 3T3 Fibroblasts

Functional activation of mutant human insulin receptor by monoclonal antibody

Insulin-like growth factor (IGF)-I A- and B-domain analogues with altered type 1 IGF and insulin receptor binding specificities

A monoclonal anti-peptide antibody reacting with the insulin receptor β-subunit : characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptors

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