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Methyl donor supplementation reduces phospho‐Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy

Neuropathology and applied neurobiology, 2023-08, Vol.49 (4), p.e12931-n/a

2023

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PP2A methylation controls sensitivity and resistance to β-amyloid–induced cognitive and electrophysiological impairments

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (12), p.3347-3352

2016

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Protein Phosphatase 2A: More Than a Passenger in the Regulation of Epithelial Cell-Cell Junctions

Frontiers in cell and developmental biology, 2019-03, Vol.7, p.30-30

2019

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Protein phosphatase 2A dysfunction in Alzheimer's disease

Frontiers in molecular neuroscience, 2014-03, Vol.7, p.16-16

2014

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Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells

Journal of neurochemistry, 2010-12, Vol.115 (6), p.1455-1465

2010

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Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation

The Journal of biological chemistry, 2021-01, Vol.296, p.100237-100237, Article 100237

2021

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Expression of protein phosphatase 2A mutants and silencing of the regulatory Bα subunit induce a selective loss of acetylated and detyrosinated microtubules

Journal of neurochemistry, 2007-05, Vol.101 (4), p.959-971

2007

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Leucine Carboxyl Methyltransferase 1 (LCMT1)-dependent Methylation Regulates the Association of Protein Phosphatase 2A and Tau Protein with Plasma Membrane Microdomains in Neuroblastoma Cells

The Journal of biological chemistry, 2013-09, Vol.288 (38), p.27396-27405

2013

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A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation

The Journal of biological chemistry, 2022-08, Vol.298 (8), p.102248-102248, Article 102248

2022

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Protein Phosphatase 2A Methyltransferase Links Homocysteine Metabolism with Tau and Amyloid Precursor Protein Regulation

The Journal of neuroscience, 2007-03, Vol.27 (11), p.2751-2759

2007

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Protein phosphatase 2A is a critical regulator of protein kinase C ζ signaling targeted by SV40 small t to promote cell growth and NF-κB activation

The EMBO journal, 1997-09, Vol.16 (18), p.5662-5671

1997

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The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies

The Journal of biological chemistry, 2012-04, Vol.287 (18), p.14984-14993

2012

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Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels

Journal of Alzheimer's disease, 2018-01, Vol.64 (1), p.223-237

2018

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A Novel Role of PP2A Methylation in the Regulation of Tight Junction Assembly and Integrity

Frontiers in cell and developmental biology, 2022-07, Vol.10, p.911279-911279

2022

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Folate Deficiency Induces In Vitro and Mouse Brain Region-Specific Downregulation of Leucine Carboxyl Methyltransferase-1 and Protein Phosphatase 2A Bα Subunit Expression That Correlate with Enhanced Tau Phosphorylation

The Journal of neuroscience, 2008-11, Vol.28 (45), p.11477-11487

2008

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Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain

The Journal of neuroscience, 2012-07, Vol.32 (27), p.9173-9181

2012

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PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation

Cell reports (Cambridge), 2020-03, Vol.30 (9), p.3171-3182.e6

2020

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Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice

Frontiers in aging neuroscience, 2014-08, Vol.6, p.214-214

2014

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Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

Nature (London), 1993-09, Vol.365 (6442), p.163-166

1993

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Cocaine Regulates the Salt-Inducible Kinase (SIK1) by Inducing Protein Phosphatase-2A Expression in Rat Brain

Journal of Drug and Alcohol Research, 2014-12, Vol.3 (3), p.k1-7

2014

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Protein phosphatase 2A dysfunction in Alzheimerâ€™s disease

Frontiers in molecular neuroscience, 2014-03, Vol.7

2014

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AT THE CROSSROADS BETWEEN TYR AND SER/THR SIGNALING: A NEW PARADIGM IN THE REGULATION OF PP2A BY SRC KINASE

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Two GTP-binding Proteins Control Calcium-dependent Exocytosis in Chromaffin Cells

The European journal of neuroscience, 1992-01, Vol.4 (1), p.98-101

1992

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A Mutation of β-Actin That Alters Depolymerization Dynamics Is Associated with Autosomal Dominant Developmental Malformations, Deafness, and Dystonia

American journal of human genetics, 2006-06, Vol.78 (6), p.947-960

2006

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PP2A methylation controls sensitivity and resistance to [Beta]-amyloid-induced cognitive and electrophysiological impairments

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (12), p.3347

2016

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Methyl donor supplementation reduces phospho‐Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy

PP2A methylation controls sensitivity and resistance to β-amyloid–induced cognitive and electrophysiological impairments

Protein Phosphatase 2A: More Than a Passenger in the Regulation of Epithelial Cell-Cell Junctions

Protein phosphatase 2A dysfunction in Alzheimer's disease

Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells

Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation

Expression of protein phosphatase 2A mutants and silencing of the regulatory Bα subunit induce a selective loss of acetylated and detyrosinated microtubules

Leucine Carboxyl Methyltransferase 1 (LCMT1)-dependent Methylation Regulates the Association of Protein Phosphatase 2A and Tau Protein with Plasma Membrane Microdomains in Neuroblastoma Cells

A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation

Protein Phosphatase 2A Methyltransferase Links Homocysteine Metabolism with Tau and Amyloid Precursor Protein Regulation

Protein phosphatase 2A is a critical regulator of protein kinase C ζ signaling targeted by SV40 small t to promote cell growth and NF-κB activation

The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies

Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels

A Novel Role of PP2A Methylation in the Regulation of Tight Junction Assembly and Integrity

Folate Deficiency Induces In Vitro and Mouse Brain Region-Specific Downregulation of Leucine Carboxyl Methyltransferase-1 and Protein Phosphatase 2A Bα Subunit Expression That Correlate with Enhanced Tau Phosphorylation

Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain

PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation

Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice

Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

Cocaine Regulates the Salt-Inducible Kinase (SIK1) by Inducing Protein Phosphatase-2A Expression in Rat Brain

Protein phosphatase 2A dysfunction in Alzheimerâ€™s disease

AT THE CROSSROADS BETWEEN TYR AND SER/THR SIGNALING: A NEW PARADIGM IN THE REGULATION OF PP2A BY SRC KINASE

Two GTP-binding Proteins Control Calcium-dependent Exocytosis in Chromaffin Cells

A Mutation of β-Actin That Alters Depolymerization Dynamics Is Associated with Autosomal Dominant Developmental Malformations, Deafness, and Dystonia

PP2A methylation controls sensitivity and resistance to [Beta]-amyloid-induced cognitive and electrophysiological impairments

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