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Navigating the kinome

Nature chemical biology, 2011-04, Vol.7 (4), p.200

2011

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1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor

The Journal of biological chemistry, 2011-12, Vol.286 (51), p.43951-43958

2011

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Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor

Clinical cancer research, 2012-01, Vol.18 (2), p.510-523

2012

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Isoxazolo[3,4- b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (19), p.5206-5208

2008

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7-Aminopyrazolo[1,5-a]pyrimidines as Potent Multitargeted Receptor Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 2008-07, Vol.51 (13), p.3777-3787

2008

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Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605

BMC cancer, 2009-09, Vol.9 (1), p.314-314, Article 314

2009

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Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (9), p.3208-3212

2012

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Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors

Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.386-390

2008

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Thienopyridine urea inhibitors of KDR kinase

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1246-1249

2007

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Novel Antibacterial Class

Antimicrobial Agents and Chemotherapy, 2003-12, Vol.47 (12), p.3831-3839

2003

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Novel Antibacterial Class: A Series of Tetracyclic Derivatives

Journal of medicinal chemistry, 2006-08, Vol.49 (16), p.4842-4856

2006

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Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3133-3136

2003

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Antimicrobial susceptibility and molecular characterization of community-acquired methicillin-resistant Staphylococcus aureus

Diagnostic microbiology and infectious disease, 2002-07, Vol.43 (3), p.225-232

2002

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An Unusual Intramolecular Hetero-Diels−Alder Cycloaddition

Journal of organic chemistry, 2005-04, Vol.70 (8), p.3332-3335

2005

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A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen

Journal of biomolecular screening, 2004-02, Vol.9 (1), p.3-11

2004

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Abstract 5532: Discovery of A-366, a novel small molecule inhibitor that uncovers an unappreciated role for G9a/GLP in the epigenetics of leukemia

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.5532-5532

2014

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Aminopyrimidinone Cdc7 Kinase Inhibitors

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (5), p.1940-1943

2012

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1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) Induces Phosphorylation of Eukaryotic Elongation Factor-2 (eEF2)

The Journal of biological chemistry, 2011-12, Vol.286 (51), p.43951-43958

2011

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Abstract C202: Discovery and initial characterization of the clinical compound ABT-348, a potent inhibitor of the VEGF, PDGF, and Aurora kinase families

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.C202-C202

2011

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Design, synthesis and structure–activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2653-2658

2005

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Erratum to “Design, synthesis and structure–activity relationships of 6- O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae” [Bioorg. Med. Chem. Lett. 15 (2005) 2653]

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (13), p.3313-3314

2005

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Novel inhibitors of bacterial protein synthesis: structure–activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3299-3302

2004

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Navigating the kinome

1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor

Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor

Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

Isoxazolo[3,4- b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

7-Aminopyrazolo[1,5-a]pyrimidines as Potent Multitargeted Receptor Tyrosine Kinase Inhibitors

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605

ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia

Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families

Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors

Thienopyridine urea inhibitors of KDR kinase

Novel Antibacterial Class

Novel Antibacterial Class: A Series of Tetracyclic Derivatives

Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents

Antimicrobial susceptibility and molecular characterization of community-acquired methicillin-resistant Staphylococcus aureus

An Unusual Intramolecular Hetero-Diels−Alder Cycloaddition

A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen

Abstract 5532: Discovery of A-366, a novel small molecule inhibitor that uncovers an unappreciated role for G9a/GLP in the epigenetics of leukemia

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

Aminopyrimidinone Cdc7 Kinase Inhibitors

1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) Induces Phosphorylation of Eukaryotic Elongation Factor-2 (eEF2)

Abstract C202: Discovery and initial characterization of the clinical compound ABT-348, a potent inhibitor of the VEGF, PDGF, and Aurora kinase families

Design, synthesis and structure–activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae

Erratum to “Design, synthesis and structure–activity relationships of 6- O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae” [Bioorg. Med. Chem. Lett. 15 (2005) 2653]

Novel inhibitors of bacterial protein synthesis: structure–activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants

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