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Function and regulation of Dyrk1A: towards understanding Down syndrome

Cellular and molecular life sciences : CMLS, 2009-10, Vol.66 (20), p.3235-3240

2009

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Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease

PloS one, 2015-08, Vol.10 (8), p.e0136950-e0136950

2015

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Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease

Journal of neurochemistry, 2008-03, Vol.104 (5), p.1333-1344

2008

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A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition

Disease models & mechanisms, 2016-08, Vol.9 (8), p.839-848

2016

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Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals

PLoS genetics, 2012-08, Vol.8 (8), p.e1002857-e1002857

2012

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Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells

The Journal of biological chemistry, 2010-10, Vol.285 (41), p.31895-31906

2010

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Dyrk1A‐mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer’s disease

Journal of neurochemistry, 2010-11, Vol.115 (3), p.574-584

2010

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Regulation of RCAN1 Protein Activity by Dyrk1A Protein-mediated Phosphorylation

The Journal of biological chemistry, 2011-11, Vol.286 (46), p.40401-40412

2011

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DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects

Neurobiology of disease, 2006-06, Vol.22 (3), p.463-472

2006

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Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP

Journal of cell science, 2012-01, Vol.125 (Pt 1), p.67-80

2012

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Negative Feedback Inhibition of NFATc1 by DYRK1A Regulates Bone Homeostasis

The Journal of biological chemistry, 2009-11, Vol.284 (48), p.33343-33351

2009

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Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α

Journal of neurochemistry, 2012-09, Vol.122 (5), p.1081-1091

2012

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Phosphorylation and Inactivation of Glycogen Synthase Kinase 3β (GSK3β) by Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A)

The Journal of biological chemistry, 2015-01, Vol.290 (4), p.2321-2333

2015

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DYRK1A-mediated Hyperphosphorylation of Tau: A FUNCTIONAL LINK BETWEEN DOWN SYNDROME AND ALZHEIMER DISEASE

The Journal of biological chemistry, 2007-11, Vol.282 (48), p.34850-34857

2007

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δ-Catenin-induced Dendritic Morphogenesis: AN ESSENTIAL ROLE OF p190RhoGEF INTERACTION THROUGH AKT1-MEDIATED PHOSPHORYLATION

The Journal of biological chemistry, 2008-01, Vol.283 (2), p.977-987

2008

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

Nature genetics, 1999-10, Vol.23 (2), p.166-175

1999

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Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates

Neuroscience letters, 2013-10, Vol.554, p.135-140

2013

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Overexpression of Dyrk1A Causes the Defects in Synaptic Vesicle Endocytosis

Neuro-Signals, 2010-01, Vol.18 (3), p.164-172

2010

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Regulation of Dyrk1A kinase activity by 14-3-3

Biochemical and biophysical research communications, 2004-10, Vol.323 (2), p.499-504

2004

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QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2324-2328

2009

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Putative therapeutic agents for the learning and memory deficits of people with Down syndrome

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3772-3776

2006

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DYRK1A-mediated Hyperphosphorylation of Tau

The Journal of biological chemistry, 2007-11, Vol.282 (48), p.34850-34857

2007

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Kinetics and regulation of pantothenate kinase from Escherichia coli

The Journal of biological chemistry, 1994-10, Vol.269 (43), p.27051-27058

1994

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Use of a fluorescent-PCR reaction to detect genomic sequence copy number and transcriptional abundance

Genome research, 1996-10, Vol.6 (10), p.1013

1996

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Expressed Sequence Tags from the Long Arm of Human Chromosome 21

Genomics (San Diego, Calif.), 1995-09, Vol.29 (2), p.383-389

1995

Volltextzugriff (PDF)

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Function and regulation of Dyrk1A: towards understanding Down syndrome

Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease

A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition

Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals

Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells

Dyrk1A‐mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer’s disease

Regulation of RCAN1 Protein Activity by Dyrk1A Protein-mediated Phosphorylation

DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects

Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP

Negative Feedback Inhibition of NFATc1 by DYRK1A Regulates Bone Homeostasis

Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α

Phosphorylation and Inactivation of Glycogen Synthase Kinase 3β (GSK3β) by Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A)

DYRK1A-mediated Hyperphosphorylation of Tau: A FUNCTIONAL LINK BETWEEN DOWN SYNDROME AND ALZHEIMER DISEASE

δ-Catenin-induced Dendritic Morphogenesis: AN ESSENTIAL ROLE OF p190RhoGEF INTERACTION THROUGH AKT1-MEDIATED PHOSPHORYLATION

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates

Overexpression of Dyrk1A Causes the Defects in Synaptic Vesicle Endocytosis

Regulation of Dyrk1A kinase activity by 14-3-3

QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors

Putative therapeutic agents for the learning and memory deficits of people with Down syndrome

DYRK1A-mediated Hyperphosphorylation of Tau

Kinetics and regulation of pantothenate kinase from Escherichia coli

Use of a fluorescent-PCR reaction to detect genomic sequence copy number and transcriptional abundance

Expressed Sequence Tags from the Long Arm of Human Chromosome 21

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