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Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates

Scientific reports, 2022-05, Vol.12 (1), p.7262-7262, Article 7262

2022

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Transient CHO expression platform for robust antibody production and its enhanced N‐glycan sialylation on therapeutic glycoproteins

Biotechnology progress, 2019-01, Vol.35 (1), p.e2724-n/a

2019

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Pyroglutamate and O-Linked Glycan Determine Functional Production of Anti-IL17A and Anti-IL22 Peptide-Antibody Bispecific Genetic Fusions

The Journal of biological chemistry, 2013-01, Vol.288 (2), p.1409-1419

2013

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Two N-Terminal Domains of Kv4 K + Channels Regulate Binding to and Modulation by KChIP1

Neuron (Cambridge, Mass.), 2004-02, Vol.41 (4), p.587-598

2004

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Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency

Scientific reports, 2016-08, Vol.6 (1), p.31899-31899, Article 31899

2016

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Swift residue-screening identifies key N-glycosylated asparagines sufficient for surface expression of neuroglycoprotein Lingo-1

FEBS letters, 2009-03, Vol.583 (6), p.1034-1038

2009

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Large-Scale Transient Production in ExpiCHO-S™ with Enhanced N-Galactosylation-Sialylation and PEI-Based Transfection

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2313, p.143

2022

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Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing

Scientific reports, 2018-03, Vol.8 (1), p.4241-15, Article 4241

2018

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A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

The Journal of biological chemistry, 2016-01, Vol.291 (3), p.1267-1276

2016

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Mechanistic understanding of the cysteine capping modifications of antibodies enables selective chemical engineering in live mammalian cells

Journal of biotechnology, 2017-04, Vol.248, p.48-58

2017

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Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: Molecular insights and effector modulation of N-acetylglucosaminyltransferase I

Biotechnology and bioengineering, 2012-07, Vol.109 (7), p.1723-1734

2012

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Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: Molecular insights and effector modulation of N-acetylglucosaminyltransferase I

Biotechnology and bioengineering, 2012-07, Vol.100 (7), p.1723-1723

2012

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Automated systems for protein crystallization

Methods (San Diego, Calif.), 2004-11, Vol.34 (3), p.329-347

2004

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Purification and Characterization of Active Plk‐1 Produced in E. coli and Baculovirus‐Infected Sf9 Insect Cells

The FASEB journal, 2007, Vol.21 (6), p.LB22-LB22

2007

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Purification and Characterization of Recombinant Activin Receptor Type IIB Kinase Expressed In Sf9 Cells

The FASEB journal, 2006-03, Vol.20 (4), p.A498-A498

2006

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Expression and purification of active protein kinase Cd (PKCd) kinase domain from E. coli

The FASEB journal, 2006-03, Vol.20 (5), p.LB54-LB54

2006

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Buteo Nesting Ecology: Evaluating Nesting of Swainson's Hawks in the Northern Great Plains

PloS one, 2015-09, Vol.10 (9), p.e0137045-e0137045

2015

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Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group

Journal of clinical oncology, 1995-07, Vol.13 (7), p.1537-1545

1995

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Dear Editor

Surgery for obesity and related diseases, 2018-11, Vol.14 (11), p.1789-1790

2018

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Dear Editor

Surgery for obesity and related diseases, 2018-11, Vol.14 (11), p.1789-1790

2018

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Dear Editor

Surgery for obesity and related diseases, 2018-11, Vol.14 (11), p.1789-1790

2018

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Dear Editor

Surgery for obesity and related diseases, 2018-11, Vol.14 (11), p.1789

2018

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Time to convert to a UK-REIT?

The Estates Gazette, 2018-07, p.58-59

2018

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Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates

Transient CHO expression platform for robust antibody production and its enhanced N‐glycan sialylation on therapeutic glycoproteins

Pyroglutamate and O-Linked Glycan Determine Functional Production of Anti-IL17A and Anti-IL22 Peptide-Antibody Bispecific Genetic Fusions

Two N-Terminal Domains of Kv4 K + Channels Regulate Binding to and Modulation by KChIP1

Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency

Swift residue-screening identifies key N-glycosylated asparagines sufficient for surface expression of neuroglycoprotein Lingo-1

Large-Scale Transient Production in ExpiCHO-S™ with Enhanced N-Galactosylation-Sialylation and PEI-Based Transfection

Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing

A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

Mechanistic understanding of the cysteine capping modifications of antibodies enables selective chemical engineering in live mammalian cells

Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: Molecular insights and effector modulation of N-acetylglucosaminyltransferase I

Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: Molecular insights and effector modulation of N-acetylglucosaminyltransferase I

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery

Automated systems for protein crystallization

Purification and Characterization of Active Plk‐1 Produced in E. coli and Baculovirus‐Infected Sf9 Insect Cells

Purification and Characterization of Recombinant Activin Receptor Type IIB Kinase Expressed In Sf9 Cells

Expression and purification of active protein kinase Cd (PKCd) kinase domain from E. coli

Buteo Nesting Ecology: Evaluating Nesting of Swainson's Hawks in the Northern Great Plains

Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group

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