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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Nature biotechnology, 2012-02, Vol.30 (2), p.184-189

2012

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Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001

Oncotarget, 2018-12, Vol.9 (102), p.37700-37714

2018

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Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers

Molecular cancer therapeutics, 2017-05, Vol.16 (5), p.871-878

2017

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Role of the aromatic hydrocarbon receptor and [ Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

Biochemical pharmacology, 2000, Vol.59 (1), p.65-85

2000

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Site-Specific 89 Zr- and 111 In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide-Alkyne Cycloaddition with a Non-natural Amino Acid

Bioconjugate chemistry, 2020-04, Vol.31 (4), p.1177-1187

2020

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Glutamate–cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress

Biochemical pharmacology, 2002-05, Vol.63 (9), p.1739-1754

2002

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A First-in-Human Phase 1 Dose Escalation and Expansion Study of the Oral CARD11-BCL10-MALT1 Signaling Pathway Inhibitor XL114 in Patients with Non-Hodgkin's Lymphoma

Blood, 2022-11, Vol.140 (Supplement 1), p.12055-12056

2022

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Site-Specific 89Zr- and 111In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide–Alkyne Cycloaddition with a Non-natural Amino Acid

Bioconjugate chemistry, 2020-04, Vol.31 (4), p.1177-1187

2020

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Characterization of the MTF-1 transcription factor from zebrafish and trout cells

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000-07, Vol.126 (3), p.325-335

2000

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Abstract 3897: Stability and safety evaluation of STRO-002, a site-specific anti-folate receptor alpha antibody-drug conjugate for the potential treatment of ovarian and endometrial cancers

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3897-3897

2019

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Abstract 742: Nonclinical safety evaluation of STRO-001, a site-specific anti-CD74 antibody-drug conjugate for the potential treatment of B-cell malignancies

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.742-742

2018

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Abstract NT-090: PRECLINICAL ACTIVITY AND SAFETY OF STRO-002, A NOVEL ADC TARGETING FOLATE RECEPTOR ALPHA FOR OVARIAN AND ENDOMETRIAL CANCER

Clinical cancer research, 2019-11, Vol.25 (22_Supplement), p.NT-090-NT-090

2019

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Abstract 1782: Discovery and activity of STRO-002, a novel ADC targeting folate receptor alpha for ovarian and endometrial cancer

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1782-1782

2018

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Tryphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements

Biochemical pharmacology, 2001-01, Vol.61 (2), p.215-225

2001

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Use of Reporter Genes and Vertebrate DNA Motifs in Transgenic Zebrafish as Sentinels for Assessing Aquatic Pollution

Environmental health perspectives, 2002-01, Vol.110 (1), p.A15-A15

2002

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Retrovirally Expressed Metal Response Element-Binding Transcription Factor-1 Normalizes Metallothionein-1 Gene Expression and Protects Cells against Zinc, but Not Cadmium, Toxicity

Toxicology and applied pharmacology, 2002-01, Vol.178 (2), p.93-101

2002

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Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins

Marine biotechnology (New York, N.Y.), 1999-03, Vol.1 (2), p.155-166

1999

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Abstract 4502: Nonclinical characterization and tolerability of a surrogate anti-mesothelin-MMAE antibody-drug conjugate

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4502-4502

2014

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Abstract 5619: Preclinical development of anti-SLC34A2 antibody drug conjugate as a therapeutic for non-small cell lung and ovarian cancers

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.5619-5619

2013

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Activation of Transcription Factors in Zebrafish Cell Cultures by Environmental Pollutants

Archives of biochemistry and biophysics, 2000-04, Vol.376 (2), p.320-327

2000

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Erratum to “Tyrphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements”: [Biochem. Pharmacol. 61 (2001) 215–225]

Biochemical pharmacology, 2002-07, Vol.64 (2), p.351-351

2002

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Tryphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements11Abbreviations: EPRE, electrophile response element; AHRE, aromatic hydrocarbon response element; MRE, metal response element; Nqo1 and NQO1, mouse NAD(P)H:quinone oxidoreductase [also called NMO1, quinone reductase, DT-diaphorase] gene and mRNA; Cyp1a1 and CYP1A1, mouse cytochrome P450 1A1 gene and mRNA; Mt1 and MT1, mouse metallothionein-1 g

Biochemical pharmacology, 2001-01, Vol.61 (2), p.215-225

2001

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Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress

Biochemical pharmacology, 2002, Vol.63 (8), p.1739-1754

2002

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Mechanisms of glutamate -cysteine ligase modifier (Gclm) and metallothionein-1 (Mt1) regulation by oxidative stress

Solis, Willy A

2001

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Protease Production by Bacteria Isolated from Laguna Chiar Khota, Potosi-Bolivia, for Protein Hydrolysates Production

Waste and biomass valorization, 2022-07, Vol.13 (7), p.3171-3181

2022

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers

Role of the aromatic hydrocarbon receptor and [ Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

Site-Specific 89 Zr- and 111 In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide-Alkyne Cycloaddition with a Non-natural Amino Acid

Glutamate–cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress

A First-in-Human Phase 1 Dose Escalation and Expansion Study of the Oral CARD11-BCL10-MALT1 Signaling Pathway Inhibitor XL114 in Patients with Non-Hodgkin's Lymphoma

Site-Specific 89Zr- and 111In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide–Alkyne Cycloaddition with a Non-natural Amino Acid

Characterization of the MTF-1 transcription factor from zebrafish and trout cells

Abstract 3897: Stability and safety evaluation of STRO-002, a site-specific anti-folate receptor alpha antibody-drug conjugate for the potential treatment of ovarian and endometrial cancers

Abstract 742: Nonclinical safety evaluation of STRO-001, a site-specific anti-CD74 antibody-drug conjugate for the potential treatment of B-cell malignancies

Abstract NT-090: PRECLINICAL ACTIVITY AND SAFETY OF STRO-002, A NOVEL ADC TARGETING FOLATE RECEPTOR ALPHA FOR OVARIAN AND ENDOMETRIAL CANCER

Abstract 1782: Discovery and activity of STRO-002, a novel ADC targeting folate receptor alpha for ovarian and endometrial cancer

Tryphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements

Use of Reporter Genes and Vertebrate DNA Motifs in Transgenic Zebrafish as Sentinels for Assessing Aquatic Pollution

Retrovirally Expressed Metal Response Element-Binding Transcription Factor-1 Normalizes Metallothionein-1 Gene Expression and Protects Cells against Zinc, but Not Cadmium, Toxicity

Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins

Abstract 4502: Nonclinical characterization and tolerability of a surrogate anti-mesothelin-MMAE antibody-drug conjugate

Abstract 5619: Preclinical development of anti-SLC34A2 antibody drug conjugate as a therapeutic for non-small cell lung and ovarian cancers

Activation of Transcription Factors in Zebrafish Cell Cultures by Environmental Pollutants

Erratum to “Tyrphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements”: [Biochem. Pharmacol. 61 (2001) 215–225]

Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress

Mechanisms of glutamate -cysteine ligase modifier (Gclm) and metallothionein-1 (Mt1) regulation by oxidative stress

Protease Production by Bacteria Isolated from Laguna Chiar Khota, Potosi-Bolivia, for Protein Hydrolysates Production

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