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Hsp90 inhibitors as anti-cancer agents, from basic discoveries to clinical development

Current pharmaceutical design, 2013, Vol.19 (3), p.366-376

2013

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The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues

Journal of antibiotics, 2017-05, Vol.70 (5), p.675-679

2017

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Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

Proceedings of the National Academy of Sciences - PNAS, 2008-10, Vol.105 (40), p.15541-15546

2008

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A Radicicol Derivative, KF58333, Inhibits Expression of Hypoxia‐inducible Factor‐1α and Vascular Endothelial Growth Factor, Angiogenesis and Growth of Human Breast Cancer Xenografts

Cancer science, 2001-12, Vol.92 (12), p.1342-1351

2001

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Conformational significance of EH21A1–A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (5), p.1588-1591

2008

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Radicicol Leads to Selective Depletion of Raf Kinase and Disrupts K-Ras-activated Aberrant Signaling Pathway

The Journal of biological chemistry, 1998-01, Vol.273 (2), p.822-828

1998

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New Molecular and Biological Mechanism of Antitumor Activities of KW-2478, a Novel Nonansamycin Heat Shock Protein 90 Inhibitor, in Multiple Myeloma Cells

Clinical cancer research, 2010-05, Vol.16 (10), p.2792-2802

2010

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Drug discovery and research of heat shock protein 90 (Hsp90) inhibitor

Folia Pharmacologica Japonica, 2013, Vol.141(1), pp.9-14

Soga, Shiro

2013

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Hsp90 Inhibitors as Anti-Cancer Agents, from Basic Discoveries to Clinical Development

Current pharmaceutical design, 2012-11, Vol.19 (3), p.366-376

2012

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Development of radicicol analogues

Current cancer drug targets, 2003-10, Vol.3 (5), p.359-369

2003

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Abstract 920: KW-2450, a novel IGF-1R/IR inhibitor, enhances the antitumor effect of lapatinib, letrozole or 4-hydroxy-tamoxifen in breast cancer cells

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.920-920

2013

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Antibiotic Radicicol Binds to the N-Terminal Domain of Hsp90 and Shares Important Biologic Activities with Geldanamycin

Cell stress & chaperones, 1998-06, Vol.3 (2), p.100-108

1998

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S1A1-2 Drug discovery and research of heat shock protein 90 (Hsp90) inhibitor

Journal of Pharmacological Sciences, 2011, Vol.115 (suppl.1), p.26-26

2011

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UCF76 Compounds, New Inhibitors of Farnesyltransferase Produced by Streptomyces

The Journal of Antibiotics, 2001/02/25, Vol.54(2), pp.182-186

2001

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UCF116, New Inhibitors of Farnesyltransferase Produced by Streptomyces

The Journal of Antibiotics, 2000/07/25, Vol.53(7), pp.720-723

2000

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Abstract 2636: Preclinical evaluation of the Hsp90 inhibitor KW-2478 in combination with bortezomib as a treatment for multiple myeloma

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.2636-2636

2010

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S2A-24-2 Drug discovery and research of Hsp90 inhibitor

Journal of Pharmacological Sciences, 2012, Vol.118 (suppl), p.36-36

2012

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UCF76 Compounds, New Inhibitors of Farnesyltransferase Produced by Steptomyces

Journal of antibiotics, 2001, Vol.54 (2), p.182-186

2001

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Abstract 3605: KW-2450, a novel orally-active dual IGF1R/IR inhibitor: Antitumor effects in vitro and in vivo

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.3605-3605

2011

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KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

Cancer research (Chicago, Ill.), 1999-06, Vol.59 (12), p.2931-2938

1999

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Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential

Bioorganic & medicinal chemistry, 2007-02, Vol.15 (3), p.1363-1382

2007

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Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

Blood, 2000-09, Vol.96 (6), p.2284-2291

2000

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Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

Proceedings of the National Academy of Sciences - PNAS, 2008-10, Vol.105 (40), p.15535-15540

2008

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Improvement of biological activity and proteolytic stability of peptides by coupling with a cyclic peptide

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (15), p.2583-2586

2003

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Stereospecific antitumor activity of radicicol oxime derivatives

Cancer chemotherapy and pharmacology, 2001-12, Vol.48 (6), p.435-445

2001

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Hsp90 inhibitors as anti-cancer agents, from basic discoveries to clinical development

The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

A Radicicol Derivative, KF58333, Inhibits Expression of Hypoxia‐inducible Factor‐1α and Vascular Endothelial Growth Factor, Angiogenesis and Growth of Human Breast Cancer Xenografts

Conformational significance of EH21A1–A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity

Radicicol Leads to Selective Depletion of Raf Kinase and Disrupts K-Ras-activated Aberrant Signaling Pathway

New Molecular and Biological Mechanism of Antitumor Activities of KW-2478, a Novel Nonansamycin Heat Shock Protein 90 Inhibitor, in Multiple Myeloma Cells

Drug discovery and research of heat shock protein 90 (Hsp90) inhibitor

Hsp90 Inhibitors as Anti-Cancer Agents, from Basic Discoveries to Clinical Development

Development of radicicol analogues

Abstract 920: KW-2450, a novel IGF-1R/IR inhibitor, enhances the antitumor effect of lapatinib, letrozole or 4-hydroxy-tamoxifen in breast cancer cells

Antibiotic Radicicol Binds to the N-Terminal Domain of Hsp90 and Shares Important Biologic Activities with Geldanamycin

S1A1-2 Drug discovery and research of heat shock protein 90 (Hsp90) inhibitor

UCF76 Compounds, New Inhibitors of Farnesyltransferase Produced by Streptomyces

UCF116, New Inhibitors of Farnesyltransferase Produced by Streptomyces

Abstract 2636: Preclinical evaluation of the Hsp90 inhibitor KW-2478 in combination with bortezomib as a treatment for multiple myeloma

S2A-24-2 Drug discovery and research of Hsp90 inhibitor

UCF76 Compounds, New Inhibitors of Farnesyltransferase Produced by Steptomyces

Abstract 3605: KW-2450, a novel orally-active dual IGF1R/IR inhibitor: Antitumor effects in vitro and in vivo

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential

Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

Improvement of biological activity and proteolytic stability of peptides by coupling with a cyclic peptide

Stereospecific antitumor activity of radicicol oxime derivatives

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