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Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

Biophysical journal, 2009-02, Vol.96 (4), p.1264-1274

Sobie, Eric A.

2009

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Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models

PLoS computational biology, 2022-11, Vol.18 (11), p.e1010098-e1010098

2022

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Regression analysis for constraining free parameters in electrophysiological models of cardiac cells

PLoS computational biology, 2010-09, Vol.6 (9), p.e1000914-e1000914

2010

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Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

Heart rhythm, 2011-11, Vol.8 (11), p.1749-1755

2011

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Quantitative approaches to drug safety: The 2022 PSP special issue

CPT: pharmacometrics and systems pharmacology, 2022-05, Vol.11 (5), p.529-531

Sobie, Eric A.

2022

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Dynamics of Calcium Sparks and Calcium Leak in the Heart

Biophysical journal, 2011-09, Vol.101 (6), p.1287-1296

2011

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Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms

The Journal of physiology, 2016-05, Vol.594 (9), p.2525-2536

2016

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Orphaned Ryanodine Receptors in the Failing Heart

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (11), p.4305-4310

2006

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Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

Nature communications, 2020-09, Vol.11 (1), p.4809-12, Article 4809

2020

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Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types

NPJ systems biology and applications, 2018-02, Vol.4 (1), p.11-11, Article 11

2018

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Inflammation as a Risk Factor in Cardiotoxicity: An Important Consideration for Screening During Drug Development

Frontiers in pharmacology, 2021-04, Vol.12, p.598549-598549

2021

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In vitro and In silico Models to Study SARS-CoV-2 Infection: Integrating Experimental and Computational Tools to Mimic "COVID-19 Cardiomyocyte"

Frontiers in physiology, 2021-02, Vol.12, p.624185

2021

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Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion

Nature communications, 2021-10, Vol.12 (1), p.6019-6019, Article 6019

2021

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Prediction of arrhythmia susceptibility through mathematical modeling and machine learning

Proceedings of the National Academy of Sciences - PNAS, 2021-09, Vol.118 (37)

2021

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Parameter Sensitivity Analysis of Stochastic Models Provides Insights into Cardiac Calcium Sparks

Biophysical journal, 2013-03, Vol.104 (5), p.1142-1150

2013

Volltextzugriff (PDF)

The Contribution of Ionic Currents to Rate-Dependent Action Potential Duration and Pattern of Reentry in a Mathematical Model of Human Atrial Fibrillation

PloS one, 2016-03, Vol.11 (3), p.e0150779-e0150779

2016

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Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence

PLoS computational biology, 2014-03, Vol.10 (3), p.e1003543-e1003543

2014

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Multifaceted roles of miR-1s in repressing the fetal gene program in the heart

Cell research, 2014-03, Vol.24 (3), p.278-292

2014

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Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes

PLoS computational biology, 2016-07, Vol.12 (7), p.e1005014-e1005014

2016

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Investigational Treatments for COVID‐19 may Increase Ventricular Arrhythmia Risk Through Drug Interactions

CPT: pharmacometrics and systems pharmacology, 2021-02, Vol.10 (2), p.100-107

2021

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Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients

Trends in pharmacological sciences (Regular ed.), 2023-05, Vol.44 (5), p.318-319

2023

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Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression

PloS one, 2014-07, Vol.9 (7), p.e101316-e101316

2014

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Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking

The Journal of biological chemistry, 2016-10, Vol.291 (44), p.23257-23267

2016

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Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors

Frontiers in pharmacology, 2023-04, Vol.14, p.1158222-1158222

2023

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Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models

Regression analysis for constraining free parameters in electrophysiological models of cardiac cells

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

Quantitative approaches to drug safety: The 2022 PSP special issue

PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes

Dynamics of Calcium Sparks and Calcium Leak in the Heart

Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms

Orphaned Ryanodine Receptors in the Failing Heart

Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types

Inflammation as a Risk Factor in Cardiotoxicity: An Important Consideration for Screening During Drug Development

In vitro and In silico Models to Study SARS-CoV-2 Infection: Integrating Experimental and Computational Tools to Mimic "COVID-19 Cardiomyocyte"

Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion

Prediction of arrhythmia susceptibility through mathematical modeling and machine learning

Parameter Sensitivity Analysis of Stochastic Models Provides Insights into Cardiac Calcium Sparks

The Contribution of Ionic Currents to Rate-Dependent Action Potential Duration and Pattern of Reentry in a Mathematical Model of Human Atrial Fibrillation

Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence

Multifaceted roles of miR-1s in repressing the fetal gene program in the heart

Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes

Investigational Treatments for COVID‐19 may Increase Ventricular Arrhythmia Risk Through Drug Interactions

Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients

Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression

Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking

Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors

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