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Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future

Current topics in medicinal chemistry, 2016-12, Vol.16 (29), p.3385-3403

2016

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Lumateperone Normalizes Pathological Levels of Acute Inflammation through Important Pathways Known to Be Involved in Mood Regulation

The Journal of neuroscience, 2023-02, Vol.43 (5), p.863-877

2023

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Discovery of ITI-333, a Novel Orally Bioavailable Molecule Targeting Multiple Receptors for the Treatment of Pain and Other Disorders

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.9355-9373

2024

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Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Biochemical and Behavioral Profiles of Phosphodiesterase Inhibition in Dopaminergic Neurotransmission

Journal of Pharmacological Sciences, 2010, Vol.114(1), pp.6-16

2010

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Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

The Journal of neuroscience, 2008-10, Vol.28 (42), p.10460-10471

2008

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Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission

Psychopharmacology, 2015-02, Vol.232 (3), p.605-621

2015

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Predator biodiversity strengthens herbivore suppression

Ecology letters, 2006-07, Vol.9 (7), p.789-796

2006

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Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disorders

Psychopharmacology, 2024-07, Vol.241 (7), p.1477-1490

2024

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Alternative prey mediate intraguild predation in the open field

Pest management science, 2022-09, Vol.78 (9), p.3939-3946

2022

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Discovery of a Tetracyclic Quinoxaline Derivative as a Potent and Orally Active Multifunctional Drug Candidate for the Treatment of Neuropsychiatric and Neurological Disorders

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2670-2682

2014

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Alternative prey and farming system mediate predation of Colorado potato beetles by generalists

Pest management science, 2022-09, Vol.78 (9), p.3769-3777

2022

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Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases

Journal of medicinal chemistry, 2016-02, Vol.59 (3), p.1149-1164

2016

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Intracellular signaling and approaches to the treatment of schizophrenia and associated cognitive impairment

Current pharmaceutical design, 2014-01, Vol.20 (31), p.5093-5103

2014

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Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses

Molecular and cellular neuroscience, 2020-01, Vol.102, p.103449-103449, Article 103449

2020

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Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

Psychopharmacology, 2016-09, Vol.233 (17), p.3113-3124

2016

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Niche saturation reveals resource partitioning among consumers

Ecology letters, 2010-03, Vol.13 (3), p.338-348

2010

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Selective Phosphodiesterase 1 Inhibition Ameliorates Vascular Function, Reduces Inflammatory Response, and Lowers Blood Pressure in Aging Animals

The Journal of pharmacology and experimental therapeutics, 2021-08, Vol.378 (2), p.173-183

2021

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The Effects of Acute and Chronic Selective Phosphodiesterase 1 Inhibition on Smooth Muscle Cell-Associated Aging Features

Frontiers in pharmacology, 2022-01, Vol.12, p.818355-818355

2022

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A review of the pharmacology and clinical profile of lumateperone for the treatment of schizophrenia

Advances in pharmacology (1990), 2021, Vol.90, p.253

2021

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Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex

Psychopharmacologia, 2012-02, Vol.219 (4), p.1065-1079

2012

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Vascular Ageing Features Caused by Selective DNA Damage in Smooth Muscle Cell

Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.2308317-2308317

2021

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Bidirectional Regulation of DARPP-32 Phosphorylation by Dopamine

The Journal of neuroscience, 1997-11, Vol.17 (21), p.8147-8155

1997

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Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5

Nature (London), 2001-03, Vol.410 (6826), p.376-380

2001

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Prey and predator biodiversity mediate aphid consumption by generalists

Biological control, 2021-09, Vol.160, p.104650, Article 104650

2021

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Amplification of Dopaminergic Signaling by a Positive Feedback Loop

Proceedings of the National Academy of Sciences - PNAS, 2000-11, Vol.97 (23), p.12840-12845

2000

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Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future

Lumateperone Normalizes Pathological Levels of Acute Inflammation through Important Pathways Known to Be Involved in Mood Regulation

Discovery of ITI-333, a Novel Orally Bioavailable Molecule Targeting Multiple Receptors for the Treatment of Pain and Other Disorders

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Biochemical and Behavioral Profiles of Phosphodiesterase Inhibition in Dopaminergic Neurotransmission

Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission

Predator biodiversity strengthens herbivore suppression

Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disorders

Alternative prey mediate intraguild predation in the open field

Discovery of a Tetracyclic Quinoxaline Derivative as a Potent and Orally Active Multifunctional Drug Candidate for the Treatment of Neuropsychiatric and Neurological Disorders

Alternative prey and farming system mediate predation of Colorado potato beetles by generalists

Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases

Intracellular signaling and approaches to the treatment of schizophrenia and associated cognitive impairment

Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses

Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

Niche saturation reveals resource partitioning among consumers

Selective Phosphodiesterase 1 Inhibition Ameliorates Vascular Function, Reduces Inflammatory Response, and Lowers Blood Pressure in Aging Animals

The Effects of Acute and Chronic Selective Phosphodiesterase 1 Inhibition on Smooth Muscle Cell-Associated Aging Features

A review of the pharmacology and clinical profile of lumateperone for the treatment of schizophrenia

Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex

Vascular Ageing Features Caused by Selective DNA Damage in Smooth Muscle Cell

Bidirectional Regulation of DARPP-32 Phosphorylation by Dopamine

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5

Prey and predator biodiversity mediate aphid consumption by generalists

Amplification of Dopaminergic Signaling by a Positive Feedback Loop

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