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Regulation and Functions of 15-Lipoxygenases in Human Macrophages

Frontiers in pharmacology, 2019-07, Vol.10, p.719-719

2019

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Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways[S]

Journal of lipid research, 2012-09, Vol.53 (9), p.2002-2013

2012

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Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages

The Journal of biological chemistry, 2016-01, Vol.291 (1), p.413-424

2016

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Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages

Frontiers in immunology, 2021-05, Vol.12, p.637778-637778

2021

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Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal

Immunity & ageing, 2022-09, Vol.19 (1), p.1-41, Article 41

2022

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A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages

Frontiers in immunology, 2018-08, Vol.9, p.1906-1906

2018

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AMP-activated Protein Kinase Suppresses Arachidonate 15-Lipoxygenase Expression in Interleukin 4-polarized Human Macrophages

The Journal of biological chemistry, 2015-10, Vol.290 (40), p.24484-24494

2015

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Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans

Immunity & ageing, 2023-06, Vol.20 (1), p.29-29, Article 29

2023

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ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2

Redox biology, 2024-06, Vol.72, p.103149-103149, Article 103149

2024

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IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors

Oncoimmunology, 2018-10, Vol.7 (10), p.e1494110-e1494110

2018

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Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis

Frontiers in immunology, 2020-07, Vol.11

2020

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Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids

The Journal of immunology (1950), 2013-10, Vol.191 (8), p.4337-4347

2013

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mPGES-1 and ALOX5/-15 in tumor-associated macrophages

Cancer and metastasis reviews, 2018-09, Vol.37 (2-3), p.317-334

2018

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Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation

Cell death and differentiation, 2021-04, Vol.28 (4), p.1301-1316

2021

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Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization

Journal of theoretical biology, 2021-01, Vol.509, p.110511-110511, Article 110511

2021

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Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2018-04, Vol.1863 (4), p.433-446

2018

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Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial

The Journal of nutrition, 2016-07, Vol.146 (7), p.1411-1419

2016

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Mitomycin C Inhibits Ribosomal RNA: A NOVEL CYTOTOXIC MECHANISM FOR BIOREDUCTIVE DRUGS

The Journal of biological chemistry, 2010-06, Vol.285 (25), p.19068-19075

2010

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Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress

The Journal of nutritional biochemistry, 2016-06, Vol.32, p.39-45

2016

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Mitomycin C Inhibits Ribosomal RNA

The Journal of biological chemistry, 2010-06, Vol.285 (25), p.19068-19075

2010

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Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity

Immunity, Inflammation and Disease, 2017-12, Vol.5 (4), p.526-540

2017

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Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial1234

The Journal of nutrition, 2016-07, Vol.146 (7), p.1411-1419

2016

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Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial 1-4

The Journal of nutrition, 2016-07, Vol.146 (7), p.1411

2016

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Palmitic acid induces but docosahexaenoic acid (DHA) inhibits inflammasome‐mediated secretion of IL‐1β in monocytes by modulating the activation of Toll‐like receptor 2 (TLR2)

The FASEB journal, 2012-04, Vol.26 (S1)

2012

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Improved insulin sensitivity and reduced adiposity with aP2 driven TLR4 overexpression in transgenic mice

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Regulation and Functions of 15-Lipoxygenases in Human Macrophages

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways[S]

Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages

Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages

Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal

A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages

AMP-activated Protein Kinase Suppresses Arachidonate 15-Lipoxygenase Expression in Interleukin 4-polarized Human Macrophages

Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans

ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2

IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors

Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis

Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids

mPGES-1 and ALOX5/-15 in tumor-associated macrophages

Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation

Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization

Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses

Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial

Mitomycin C Inhibits Ribosomal RNA: A NOVEL CYTOTOXIC MECHANISM FOR BIOREDUCTIVE DRUGS

Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress

Mitomycin C Inhibits Ribosomal RNA

Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity

Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial1234

Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial 1-4

Palmitic acid induces but docosahexaenoic acid (DHA) inhibits inflammasome‐mediated secretion of IL‐1β in monocytes by modulating the activation of Toll‐like receptor 2 (TLR2)

Improved insulin sensitivity and reduced adiposity with aP2 driven TLR4 overexpression in transgenic mice

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