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Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

Cancer research (Chicago, Ill.), 2007-07, Vol.67 (13), p.6383-6391

2007

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The First Asymmetric Total Syntheses of (+)-Lycorine and (+)-1-Deoxylycorine

Journal of the American Chemical Society, 1996-07, Vol.118 (26), p.6210-6219

1996

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Preparation of fluoro- and hydroxy-4-(phosphonomethyl)-D,L-phenylalanine suitably protected for solid-phase synthesis of peptides containing hydrolytically stable analogs of O-phosphotyrosine

Journal of organic chemistry, 1993-03, Vol.58 (6), p.1336-1340

1993

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Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists

Journal of medicinal chemistry, 2004-04, Vol.47 (8), p.2037-2061

2004

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The first asymmetric synthesis of a lycorine alkaloid. Total synthesis of (+)-1-deoxylycorine

Journal of the American Chemical Society, 1993-08, Vol.115 (17), p.7904-7905

1993

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Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: Synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes

Bioorganic & medicinal chemistry letters, 2002-04, Vol.12 (7), p.1103-1107

2002

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Nonhydrolyzable Phosphotyrosyl Mimetics for the Preparation Of Phosphatase-Resistant SH2 Domain Inhibitors

Biochemistry (Easton), 1994-05, Vol.33 (21), p.6490-6494

1994

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Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4308-4318

1997

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Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists

Journal of medicinal chemistry, 1997-08, Vol.40 (18), p.2843-2857

1997

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Non-amine based analogs of lavendustin A as protein-tyrosine kinase inhibitors

Journal of medicinal chemistry, 1993-10, Vol.36 (20), p.3010-3014

1993

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Hydroxylated 2-(5'-salicyl)naphthalenes as protein-tyrosine kinase inhibitors

Journal of medicinal chemistry, 1993-10, Vol.36 (20), p.3015-3020

1993

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Bimolecular cyclization of 2-fluoro-N-(hydroxyalkyl)benzamides. 2. Synthesis and structural characterization of 17- and 20-membered macrocycles

Journal of organic chemistry, 1991-11, Vol.56 (24), p.6952-6954

1991

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Why Is Phosphonodifluoromethyl Phenylalanine a More Potent Inhibitory Moiety Than Phosphonomethyl Phenylalanine Toward Protein-Tyrosine Phosphatases

Biochemical and biophysical research communications, 1995-11, Vol.216 (3), p.976-984

1995

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A general method for the preparation of benzylic α,α-difluorophosphonic acids; non-hydrolyzable mimemtics of phosphotyrosine

Tetrahedron letters, 1992-07, Vol.33 (29), p.4137-4140

1992

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Enantioselective synthesis of N-boc and N-fmoc protected diethyl 4-phosphono(difluoromethyl)-L-phenylalanine; agents suitable for the solid-phase synthesis of peptides containing nonhydrolyzable analogues of O-phosphotyrosine

Tetrahedron letters, 1994, Vol.35 (4), p.551-554

1994

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A Proteasome Specific Binding Assay for Quantitation of Constitutive and Immunoproteasome Active Sites

Blood, 2005-11, Vol.106 (11), p.2472-2472

2005

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Pharmacokinetics, Pharmacodynamics and Anti-Tumor Efficacy of PR-171, a Novel Inhibitor of the 20S Proteasome

Blood, 2005-11, Vol.106 (11), p.609-609

2005

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Biochemical and Cellular Characterization of the Novel Proteasome Inhibitor PR-171

Blood, 2005-11, Vol.106 (11), p.1588-1588

2005

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Synthesis of 4-phosphono(difluoromethyl)-D,L-phenylalanine and N-boc and N-Fmoc derivatives suitably protected for solid-phase synthesis of nonhydrolyzable phosphotyrosyl peptide analogues

Tetrahedron letters, 1993-06, Vol.34 (26), p.4125-4128

1993

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Phosphotyrosyl-Based Motifs in the Structure-Based Design of Protein Tyrosine Kinase-Dependent Signal Transduction Inhibitors

Current pharmaceutical design, 1997-06, Vol.3 (3), p.291-304

1997

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ENANTIOSELECTIVE SYNTHESIS OF N-Boc AND N-Fmoc PROTECTED DIETHYL 4-PHOSPHONO(DIFLUOROMETHYL)-L-PHENYLALANINE (F2Pmp)

Organic preparations and procedures international, 1996-02, Vol.28 (1), p.77-81

1996

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Deprotection and cleavage methods for protected peptide resins containing 4-[(diethylphosphono)difluoromethyl]-D,L-phenylalanine residues

Tetrahedron letters, 1993-10, Vol.34 (44), p.7039-7042

1993

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Cyclic Peptide Inhibitors of Phosphatidylinositol 3-Kinase p85 SH2 Domain Binding

Biochemical and biophysical research communications, 1994-06, Vol.201 (3), p.1148-1153

1994

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Norleucine as a replacement for methionine in phosphatase-resistant linear and cyclic peptides which bind to p85 SH2 domains

Bioorganic & medicinal chemistry letters, 1994-08, Vol.4 (15), p.1879-1882

1994

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Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

Immunity (Cambridge, Mass.), 2013-07, Vol.39 (1), p.74-88

2013

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Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

The First Asymmetric Total Syntheses of (+)-Lycorine and (+)-1-Deoxylycorine

Preparation of fluoro- and hydroxy-4-(phosphonomethyl)-D,L-phenylalanine suitably protected for solid-phase synthesis of peptides containing hydrolytically stable analogs of O-phosphotyrosine

Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists

The first asymmetric synthesis of a lycorine alkaloid. Total synthesis of (+)-1-deoxylycorine

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: Synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes

Nonhydrolyzable Phosphotyrosyl Mimetics for the Preparation Of Phosphatase-Resistant SH2 Domain Inhibitors

Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors

Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists

Non-amine based analogs of lavendustin A as protein-tyrosine kinase inhibitors

Hydroxylated 2-(5'-salicyl)naphthalenes as protein-tyrosine kinase inhibitors

Bimolecular cyclization of 2-fluoro-N-(hydroxyalkyl)benzamides. 2. Synthesis and structural characterization of 17- and 20-membered macrocycles

Why Is Phosphonodifluoromethyl Phenylalanine a More Potent Inhibitory Moiety Than Phosphonomethyl Phenylalanine Toward Protein-Tyrosine Phosphatases

A general method for the preparation of benzylic α,α-difluorophosphonic acids; non-hydrolyzable mimemtics of phosphotyrosine

Enantioselective synthesis of N-boc and N-fmoc protected diethyl 4-phosphono(difluoromethyl)-L-phenylalanine; agents suitable for the solid-phase synthesis of peptides containing nonhydrolyzable analogues of O-phosphotyrosine

A Proteasome Specific Binding Assay for Quantitation of Constitutive and Immunoproteasome Active Sites

Pharmacokinetics, Pharmacodynamics and Anti-Tumor Efficacy of PR-171, a Novel Inhibitor of the 20S Proteasome

Biochemical and Cellular Characterization of the Novel Proteasome Inhibitor PR-171

Synthesis of 4-phosphono(difluoromethyl)-D,L-phenylalanine and N-boc and N-Fmoc derivatives suitably protected for solid-phase synthesis of nonhydrolyzable phosphotyrosyl peptide analogues

Phosphotyrosyl-Based Motifs in the Structure-Based Design of Protein Tyrosine Kinase-Dependent Signal Transduction Inhibitors

ENANTIOSELECTIVE SYNTHESIS OF N-Boc AND N-Fmoc PROTECTED DIETHYL 4-PHOSPHONO(DIFLUOROMETHYL)-L-PHENYLALANINE (F2Pmp)

Deprotection and cleavage methods for protected peptide resins containing 4-[(diethylphosphono)difluoromethyl]-D,L-phenylalanine residues

Cyclic Peptide Inhibitors of Phosphatidylinositol 3-Kinase p85 SH2 Domain Binding

Norleucine as a replacement for methionine in phosphatase-resistant linear and cyclic peptides which bind to p85 SH2 domains

Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

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