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Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

Journal of the American Chemical Society, 2010-02, Vol.132 (6), p.1960-1965

2010

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Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment

Bioconjugate chemistry, 2014-03, Vol.25 (3), p.611-617

2014

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Bromopyridazinedione-mediated protein and peptide bioconjugation

Chemical communications (Cambridge, England), 2011, Vol.47 (31), p.8781

2011

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Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation

Chemical communications (Cambridge, England), 2013-01, Vol.49 (74), p.8187-8189

2013

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Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)

Chemical communications (Cambridge, England), 2015-07, Vol.51 (53), p.10624-10627

2015

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In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation

Bioconjugate chemistry, 2011-02, Vol.22 (2), p.132-136

2011

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Substrate spectrum of ω-transaminase from Chromobacterium violaceum DSM30191 and its potential for biocatalysis

Enzyme and microbial technology, 2007-10, Vol.41 (5), p.628-637

2007

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Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

Organic & biomolecular chemistry, 2017-04, Vol.15 (14), p.2947-2952

2017

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Homogeneous Bispecifics by Disulfide Bridging

Bioconjugate chemistry, 2014-08, Vol.25 (8), p.1395-1401

2014

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Directed evolution to re-adapt a co-evolved network within an enzyme

Journal of biotechnology, 2012-01, Vol.157 (1), p.237-245

2012

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Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

Chemical communications (Cambridge, England), 2011-05, Vol.47 (19), p.5452-5454

2011

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A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

Organic & biomolecular chemistry, 2015-04, Vol.13 (14), p.4165-4168

2015

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A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

Organic & biomolecular chemistry, 2015-08, Vol.13 (29), p.7946-7949

2015

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Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody

RSC advances, 2017-01, Vol.7 (15), p.9073-9077

2017

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Correction: Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

Organic & biomolecular chemistry, 2021-04, Vol.19 (13), p.324-324

2021

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Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents

Organic & biomolecular chemistry, 2014-01, Vol.12 (4), p.557-560

2014

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Bromomaleimide-Linked Bioconjugates Are Cleavable in Mammalian Cells

Chembiochem : a European journal of chemical biology, 2012-01, Vol.13 (1), p.39-41

2012

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Bromomaleimides: new reagents for the selective and reversible modification of cysteine

Chemical communications (Cambridge, England), 2009-01 (43), p.6583-6585

2009

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A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

Nature communications, 2015-03, Vol.6 (1), p.6645, Article 6645

2015

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A rapid, site-selective and efficient route to the dual modification of DARPins

Chemical communications (Cambridge, England), 2014-05, Vol.50 (38), p.4898-4900

2014

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Enhancing and Reversing the Stereoselectivity of Escherichia coli Transketolase via Single-Point Mutations

Advanced synthesis & catalysis, 2008-11, Vol.350 (16), p.2631-2638

2008

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Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde

Journal of biotechnology, 2008-04, Vol.134 (3), p.240-245

2008

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Bioconjugation of Green Fluorescent Protein via an Unexpectedly Stable Cyclic Sulfonium Intermediate

Chembiochem : a European journal of chemical biology, 2012-06, Vol.13 (9), p.1283-1285

2012

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Directed evolution of transketolase activity on non-phosphorylated substrates

Journal of biotechnology, 2007-09, Vol.131 (4), p.425-432

2007

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Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

Organic & biomolecular chemistry, 2014-10, Vol.12 (37), p.7261-7269

2014

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Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment

Bromopyridazinedione-mediated protein and peptide bioconjugation

Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)

In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation

Substrate spectrum of ω-transaminase from Chromobacterium violaceum DSM30191 and its potential for biocatalysis

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

Homogeneous Bispecifics by Disulfide Bridging

Directed evolution to re-adapt a co-evolved network within an enzyme

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody

Correction: Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents

Bromomaleimide-Linked Bioconjugates Are Cleavable in Mammalian Cells

Bromomaleimides: new reagents for the selective and reversible modification of cysteine

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

A rapid, site-selective and efficient route to the dual modification of DARPins

Enhancing and Reversing the Stereoselectivity of Escherichia coli Transketolase via Single-Point Mutations

Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde

Bioconjugation of Green Fluorescent Protein via an Unexpectedly Stable Cyclic Sulfonium Intermediate

Directed evolution of transketolase activity on non-phosphorylated substrates

Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

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