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Leishmania Protein Kinases: Important Regulators of the Parasite Life Cycle and Molecular Targets for Treating Leishmaniasis

Microorganisms (Basel), 2021-03, Vol.9 (4), p.691

2021

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Leishmania donovani 90 kD Heat Shock Protein - Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity

Scientific reports, 2019-03, Vol.9 (1), p.5074, Article 5074

2019

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A Radioactive-free Kinase Inhibitor Discovery Assay Against the Trypanosoma brucei Glycogen Synthase Kinase-3 short ( Tb GSK-3s)

Bio-protocol, 2020-01, Vol.10 (2), p.e3493-e3493

2020

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2-(4-Nitrophenyl)isothiazol-3(2H)-one: A Promising Selective Agent against Hepatocellular Carcinoma Cells

Pharmaceuticals (Basel, Switzerland), 2024-05, Vol.17 (6), p.673

2024

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Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death

Parasites & vectors, 2010-11, Vol.3 (1), p.107-107

2010

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Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.199-210

2020

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Trypanosomatid apoptosis: 'Apoptosis' without the canonical regulators

Virulence, 2011-05, Vol.2 (3), p.253-256

2011

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inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

Parasites & vectors, 2014-05, Vol.7 (1), p.234-234, Article 234

2014

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Three new trixane glycosides obtained from the leaves of Jungia sellowii Less. using centrifugal partition chromatography

Beilstein journal of organic chemistry, 2016-04, Vol.12 (1), p.674-683

2016

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Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents

Virulence, 2018-01, Vol.9 (1), p.1658-1668

2018

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Protein Sample Preparation for Proteomic Analysis in Leishmania donovani

Bio-protocol, 2014-03, Vol.4 (5)

2014

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Orphan Receptor Promiscuity in the Induction of Cytochromes P450 by Xenobiotics

The Journal of biological chemistry, 2001-04, Vol.276 (16), p.12822-12826

2001

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Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1

Biochemical journal, 2001-04, Vol.355 (Pt 1), p.71-78

2001

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ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains

Molecular membrane biology, 2010-01, Vol.27 (1), p.45-62

2010

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Induction of protective cellular immune responses against experimental visceral leishmaniasis mediated by dendritic cells pulsed with the N-terminal domain of Leishmania infantum elongation factor-2 and CpG oligodeoxynucleotides

Molecular immunology, 2018-11, Vol.103, p.7-20

2018

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Vaccination with Leishmania histone H1-pulsed dendritic cells confers protection in murine visceral leishmaniasis

Vaccine, 2012-07, Vol.30 (34), p.5086-5093

2012

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Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth

Antimicrobial agents and chemotherapy, 2019-06, Vol.63 (6)

2019

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SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani

Journal of proteomics, 2020-02, Vol.213, p.103617-103617, Article 103617

2020

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Selection of molecular targets for drug development against trypanosomatids

Sub-cellular biochemistry, 2014, Vol.74, p.43

2014

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Leishmania dual‐specificity tyrosine‐regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype

Molecular microbiology, 2020-05, Vol.113 (5), p.983-1002

2020

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Lipophilic conformationally constrained spiro carbocyclic 2,6‐diketopiperazine‐1‐acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study

Chemical biology & drug design, 2018-02, Vol.91 (2), p.408-421

2018

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The loss of virulence of histone H1 overexpressing Leishmania donovani parasites is directly associated with a reduction of HSP83 rate of translation

Molecular microbiology, 2013-06, Vol.88 (5), p.1015-1031

2013

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The Leishmania donovani histidine acid ecto-phosphatase Ld MAcP: insight into its structure and function

Biochemical journal, 2015-05, Vol.467 (3), p.473-486

2015

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The Leishmania donovani histidine acid ecto-phosphatase LdMAcP: insight into its structure and function

Biochemical journal, 2015-05, Vol.467 (3), p.473-486

2015

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Leishmania Protein Kinases: Important Regulators of the Parasite Life Cycle and Molecular Targets for Treating Leishmaniasis

Leishmania donovani 90 kD Heat Shock Protein - Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity

A Radioactive-free Kinase Inhibitor Discovery Assay Against the Trypanosoma brucei Glycogen Synthase Kinase-3 short ( Tb GSK-3s)

2-(4-Nitrophenyl)isothiazol-3(2H)-one: A Promising Selective Agent against Hepatocellular Carcinoma Cells

Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death

Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

Trypanosomatid apoptosis: 'Apoptosis' without the canonical regulators

inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

Three new trixane glycosides obtained from the leaves of Jungia sellowii Less. using centrifugal partition chromatography

Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents

Protein Sample Preparation for Proteomic Analysis in Leishmania donovani

Orphan Receptor Promiscuity in the Induction of Cytochromes P450 by Xenobiotics

Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1

ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains

Induction of protective cellular immune responses against experimental visceral leishmaniasis mediated by dendritic cells pulsed with the N-terminal domain of Leishmania infantum elongation factor-2 and CpG oligodeoxynucleotides

Vaccination with Leishmania histone H1-pulsed dendritic cells confers protection in murine visceral leishmaniasis

Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth

Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani

Selection of molecular targets for drug development against trypanosomatids

Leishmania dual‐specificity tyrosine‐regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype

Lipophilic conformationally constrained spiro carbocyclic 2,6‐diketopiperazine‐1‐acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study

The loss of virulence of histone H1 overexpressing Leishmania donovani parasites is directly associated with a reduction of HSP83 rate of translation

The Leishmania donovani histidine acid ecto-phosphatase Ld MAcP: insight into its structure and function

The Leishmania donovani histidine acid ecto-phosphatase LdMAcP: insight into its structure and function

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