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Another Step Toward Qualification of Pediatric Physiologically Based Pharmacokinetic Models to Facilitate Inclusivity and Diversity in Pediatric Clinical Studies

Clinical pharmacology and therapeutics, 2023-03, Vol.113 (3), p.735-745

2023

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Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations

CPT: pharmacometrics and systems pharmacology, 2022-03, Vol.11 (3), p.373-383

2022

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Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis

Clinical pharmacology and therapeutics, 2023-12, Vol.114 (6), p.1264-1273

2023

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Muscle Pressure Correlates With Pain Levels in Fibromyalgia Patients

Journal of clinical rheumatology, 2024-03, Vol.30 (2), p.79

2024

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Integration of Omics Data Sources to Inform Mechanistic Modeling of Immune‐Oncology Therapies: A Tutorial for Clinical Pharmacologists

Clinical pharmacology and therapeutics, 2020-04, Vol.107 (4), p.858-870

2020

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Development and application of a pediatric mechanistic kidney model

CPT: pharmacometrics and systems pharmacology, 2022-07, Vol.11 (7), p.854-866

2022

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The Vast Majority of Patients With Fibromyalgia Have a Straight Neck Observed on a Lateral View Radiograph of the Cervical Spine: An Aid in the Diagnosis of Fibromyalgia and a Possible Clue to the Etiology

Journal of clinical rheumatology, 2023-03, Vol.29 (2), p.91

2023

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Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study

Pharmaceutics, 2023-07, Vol.15 (7), p.1922

2023

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A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development

CPT: pharmacometrics and systems pharmacology, 2021-09, Vol.10 (9), p.967-972

2021

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Prediction of liver volume – a population‐based approach to meta‐analysis of paediatric, adult and geriatric populations – an update

Biopharmaceutics & drug disposition, 2017-05, Vol.38 (4), p.290-300

2017

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Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept

Toxicology mechanisms and methods, 2017-02, Vol.27 (2), p.88-99

2017

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Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs

CPT: pharmacometrics and systems pharmacology, 2021-11, Vol.10 (11), p.1382-1395

2021

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A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

CPT: pharmacometrics and systems pharmacology, 2019-11, Vol.8 (11), p.773-776

2019

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Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

Nature chemical biology, 2011-10, Vol.7 (12), p.902

2011

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Gender differences in the slow delayed ( I Ks ) but not in inward ( I K1 ) rectifier K + currents of canine Purkinje fibre cardiac action potential: key roles for I Ks , β ‐adrenoceptor stimulation, pacing rate and gender

British journal of pharmacology, 2006-03, Vol.147 (6), p.653-660

2006

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On digraphs with polygonal restricted numerical range

Linear algebra and its applications, 2022-06, Vol.642, p.285-310

2022

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Upper bounds for positive semidefinite propagation time

Discrete mathematics, 2022-09, Vol.345 (9), p.112967, Article 112967

2022

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Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in Beagle dog left ventricular midmyocardial myocytes

Journal of pharmacological and toxicological methods, 2009-07, Vol.60 (1), p.94-106

2009

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Evidence for gender differences in electrophysiological properties of canine Purkinje fibres

British journal of pharmacology, 2004-08, Vol.142 (8), p.1255-1264

2004

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An in silico PBPK-PD coupled approach to assess zolpidem effect on pre-clinically and clinically measured cardiac repolarisation parameters in the absence and presence of a circadian model of plasma ion concentration

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.359-360

2016

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On Newman's Conjecture and Prime Trees

Integers (Berlin, Germany), 2009-06, Vol.9 (2), p.117-128

2009

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The Chemical and Computational Biology of Inflammation

Small, Ben

2012

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Businesses must be partner in creating future workforce

Journal of Business, 2016-05, Vol.31 (10), p.A3

Small, Ben

2016

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Validation of a voltage-sensitive dye-based method for assessing dog myocyte action potential duration

Journal of pharmacological and toxicological methods, 2008-09, Vol.58 (2), p.156-156

2008

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Gender differences in the slow delayed (IKs) but not in inward (IK1) rectifier K+ currents of canine Purkinje fibre cardiac action potential: key roles for IKs, [beta]-adrenoceptor stimulation, pacing rate and gender

British journal of pharmacology, 2006-03, Vol.147 (6), p.653

2006

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Another Step Toward Qualification of Pediatric Physiologically Based Pharmacokinetic Models to Facilitate Inclusivity and Diversity in Pediatric Clinical Studies

Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations

Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis

Muscle Pressure Correlates With Pain Levels in Fibromyalgia Patients

Integration of Omics Data Sources to Inform Mechanistic Modeling of Immune‐Oncology Therapies: A Tutorial for Clinical Pharmacologists

Development and application of a pediatric mechanistic kidney model

The Vast Majority of Patients With Fibromyalgia Have a Straight Neck Observed on a Lateral View Radiograph of the Cervical Spine: An Aid in the Diagnosis of Fibromyalgia and a Possible Clue to the Etiology

Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study

A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development

Prediction of liver volume – a population‐based approach to meta‐analysis of paediatric, adult and geriatric populations – an update

Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept

Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs

A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

Gender differences in the slow delayed ( I Ks ) but not in inward ( I K1 ) rectifier K + currents of canine Purkinje fibre cardiac action potential: key roles for I Ks , β ‐adrenoceptor stimulation, pacing rate and gender

On digraphs with polygonal restricted numerical range

Upper bounds for positive semidefinite propagation time

Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in Beagle dog left ventricular midmyocardial myocytes

Evidence for gender differences in electrophysiological properties of canine Purkinje fibres

An in silico PBPK-PD coupled approach to assess zolpidem effect on pre-clinically and clinically measured cardiac repolarisation parameters in the absence and presence of a circadian model of plasma ion concentration

On Newman's Conjecture and Prime Trees

The Chemical and Computational Biology of Inflammation

Businesses must be partner in creating future workforce

Validation of a voltage-sensitive dye-based method for assessing dog myocyte action potential duration

Gender differences in the slow delayed (IKs) but not in inward (IK1) rectifier K+ currents of canine Purkinje fibre cardiac action potential: key roles for IKs, [beta]-adrenoceptor stimulation, pacing rate and gender

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