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Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

CA: a cancer journal for clinicians, 2017-09, Vol.67 (5), p.378-397

2017

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Cytokines, Obesity, and Cancer: New Insights on Mechanisms Linking Obesity to Cancer Risk and Progression

Annual review of medicine, 2013-01, Vol.64 (1), p.45-57

2013

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Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

The Journal of clinical investigation, 2011-04, Vol.121 (4), p.1231-1241

2011

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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

Nature reviews. Cancer, 2008-04, Vol.8 (4), p.253-267

2008

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Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression

Cell cycle (Georgetown, Tex.), 2003-07, Vol.2 (4), p.336-342

2003

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p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted Therapies

Clinical cancer research, 2011-01, Vol.17 (1), p.12-18

2011

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Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b-Mediated Malignant Progression

Cancer research (Chicago, Ill.), 2016-01, Vol.76 (2), p.491-504

2016

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p27 transcriptionally coregulates cJun to drive programs of tumor progression

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (14), p.7005-7014

2019

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mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation

Molecular cell, 2008-06, Vol.30 (6), p.701-711

2008

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VEGFA activates an epigenetic pathway upregulating ovarian cancer‐initiating cells

EMBO molecular medicine, 2017-03, Vol.9 (3), p.304-318

2017

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C-terminally phosphorylated p27 activates self-renewal driver genes to program cancer stem cell expansion, mammary hyperplasia and cancer

Nature communications, 2024-06, Vol.15 (1), p.5152-18, Article 5152

2024

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p27 as a Transcriptional Regulator: New Roles in Development and Cancer

Cancer research (Chicago, Ill.), 2020-09, Vol.80 (17), p.3451-3458

2020

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Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy

Nature reviews. Cancer, 2014-01, Vol.14 (1), p.26

2014

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MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer

Clinical cancer research, 2016-02, Vol.22 (4), p.935-947

2016

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

Nature medicine, 2002-10, Vol.8 (10), p.1153-1160

2002

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Long-Range Activation of GREB1 by Estrogen Receptor via Three Distal Consensus Estrogen-Responsive Elements in Breast Cancer Cells

Molecular endocrinology (Baltimore, Md.), 2007-11, Vol.21 (11), p.2651-2662

2007

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Obtaining Human Breast Adipose Cells for Breast Cancer Cell Co-culture Studies

STAR protocols, 2020-12, Vol.1 (3), p.100197-100197, Article 100197

2020

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A low-glucose eating pattern is associated with improvements in glycemic variability among women at risk for postmenopausal breast cancer: an exploratory analysis

Frontiers in nutrition (Lausanne), 2024-04, Vol.11, p.1301427-1301427

2024

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PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy

Breast cancer research and treatment, 2013-04, Vol.138 (2), p.369-381

2013

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Combined Src and Aromatase Inhibition Impairs Human Breast Cancer Growth In vivo and Bypass Pathways Are Activated in AZD0530-Resistant Tumors

Clinical cancer research, 2009-05, Vol.15 (10), p.3396-3405

2009

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Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression

Scientific reports, 2018-03, Vol.8 (1), p.5306-11, Article 5306

2018

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The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development

Cell metabolism, 2020-06, Vol.31 (6), p.1154-1172.e9

2020

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ERα Phosphorylation at Y537 by Src Triggers E6-AP-ERα Binding, ERα Ubiquitylation, Promoter Occupancy, and Target Gene Expression

Molecular endocrinology (Baltimore, Md.), 2012-09, Vol.26 (9), p.1567-1577

2012

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p27 as Jekyll and Hyde: Regulation of cell cycle and cell motility

Cell cycle (Georgetown, Tex.), 2009-11, Vol.8 (21), p.3455-3461

2009

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Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells

Clinical cancer research, 2018-10, Vol.24 (19), p.4874-4886

2018

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Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Cytokines, Obesity, and Cancer: New Insights on Mechanisms Linking Obesity to Cancer Risk and Progression

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression

p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted Therapies

Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b-Mediated Malignant Progression

p27 transcriptionally coregulates cJun to drive programs of tumor progression

mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation

VEGFA activates an epigenetic pathway upregulating ovarian cancer‐initiating cells

C-terminally phosphorylated p27 activates self-renewal driver genes to program cancer stem cell expansion, mammary hyperplasia and cancer

p27 as a Transcriptional Regulator: New Roles in Development and Cancer

Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy

MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

Long-Range Activation of GREB1 by Estrogen Receptor via Three Distal Consensus Estrogen-Responsive Elements in Breast Cancer Cells

Obtaining Human Breast Adipose Cells for Breast Cancer Cell Co-culture Studies

A low-glucose eating pattern is associated with improvements in glycemic variability among women at risk for postmenopausal breast cancer: an exploratory analysis

PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy

Combined Src and Aromatase Inhibition Impairs Human Breast Cancer Growth In vivo and Bypass Pathways Are Activated in AZD0530-Resistant Tumors

Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression

The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development

ERα Phosphorylation at Y537 by Src Triggers E6-AP-ERα Binding, ERα Ubiquitylation, Promoter Occupancy, and Target Gene Expression

p27 as Jekyll and Hyde: Regulation of cell cycle and cell motility

Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells

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