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Selective Thyroid Hormone Receptor-β Activation: A Strategy for Reduction of Weight, Cholesterol, and Lipoprotein (a) with Reduced Cardiovascular Liability

Proceedings of the National Academy of Sciences - PNAS, 2003-08, Vol.100 (17), p.10067-10072

2003

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Effects of the Thyroid Hormone Receptor Agonist GC-1 on Metabolic Rate and Cholesterol in Rats and Primates: Selective Actions Relative to 3,5,3′-Triiodo-l-Thyronine

Endocrinology (Philadelphia), 2004-04, Vol.145 (4), p.1656-1661

2004

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Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.9010-9026

2015

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Reduction of Skeletal Muscle Atrophy by a Proteasome Inhibitor in a Rat Model of Denervation

Experimental biology and medicine (Maywood, N.J.), 2006-03, Vol.231 (3), p.335-341

2006

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Thyroid Receptor Ligands. 1. Agonist Ligands Selective for the Thyroid Receptor β1

Journal of medicinal chemistry, 2003-04, Vol.46 (9), p.1580-1588

2003

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Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold

Journal of medicinal chemistry, 2006-12, Vol.49 (26), p.7596-7599

2006

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Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.3015-3025

2007

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Pharmacologic Profile of the Dihydropyrimidine Calcium Channel Blockers SQ 32,547 and SQ 32,946

Journal of cardiovascular pharmacology, 1995-08, Vol.26 (2), p.289-294

1995

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Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats

Endocrinology (Philadelphia), 2007-01, Vol.148 (1), p.4-12

2007

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Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity

American journal of physiology. Heart and circulatory physiology, 2004-10, Vol.287 (4), p.H1747-H1755

2004

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PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.673-678

2018

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Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor

ACS medicinal chemistry letters, 2019-06, Vol.10 (6), p.911-916

2019

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Diphenylpyridylethanamine (DPPE) Derivatives as Cholesteryl Ester Transfer Protein (CETP) Inhibitors

Journal of medicinal chemistry, 2012-07, Vol.55 (13), p.6162-6175

2012

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Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (3), p.860-864

2014

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N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2794-2798

2009

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Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 2. Structure-Activity Studies on Benzopyranylcyanoguanidines; Modification of the Benzopyran Ring

Journal of medicinal chemistry, 1995-05, Vol.38 (11), p.1966-1973

1995

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Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KA TP) Openers. 6. Effect of Modifications at C6 of Benzopyranyl Cyanoguanidines

Journal of medicinal chemistry, 1999-09, Vol.42 (18), p.3711-3717

1999

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Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4487-4490

2007

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Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KATP) Openers. 5. Identification of 4-(N-Aryl)-Substituted Benzopyran Derivatives with High Selectivity

Journal of medicinal chemistry, 1997-01, Vol.40 (1), p.24-34

1997

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Ruthenium Red Improves Postischemic Contractile Function in Isolated Rat Hearts

Journal of cardiovascular pharmacology, 1990-11, Vol.16 (5), p.783-789

1990

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Cardioselective anti-ischemic ATP-sensitive potassium channel openers

Journal of medicinal chemistry, 1993-11, Vol.36 (24), p.3971-3974

1993

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Preconditioning in rat hearts is independent of mitochondrial F1F0 ATPase inhibition

American journal of physiology. Heart and circulatory physiology, 1998-01, Vol.274 (1), p.H90

1998

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Reduction of ischemic damage in isolated rat hearts by the potassium channel opener, RP 52891

European journal of pharmacology, 1990-11, Vol.191 (1), p.11-18

1990

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In vitro effects of capsaicin: antiarrhythmic and antiischemic activity

European journal of pharmacology, 1995-01, Vol.272 (2), p.269-278

1995

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Pharmacologic profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs

Journal of cardiovascular pharmacology, 1990-12, Vol.16 (6), p.853-864

1990

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Selective Thyroid Hormone Receptor-β Activation: A Strategy for Reduction of Weight, Cholesterol, and Lipoprotein (a) with Reduced Cardiovascular Liability

Effects of the Thyroid Hormone Receptor Agonist GC-1 on Metabolic Rate and Cholesterol in Rats and Primates: Selective Actions Relative to 3,5,3′-Triiodo-l-Thyronine

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)

Reduction of Skeletal Muscle Atrophy by a Proteasome Inhibitor in a Rat Model of Denervation

Thyroid Receptor Ligands. 1. Agonist Ligands Selective for the Thyroid Receptor β1

Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold

Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications

Pharmacologic Profile of the Dihydropyrimidine Calcium Channel Blockers SQ 32,547 and SQ 32,946

Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats

Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor

Diphenylpyridylethanamine (DPPE) Derivatives as Cholesteryl Ester Transfer Protein (CETP) Inhibitors

Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors

N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation

Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 2. Structure-Activity Studies on Benzopyranylcyanoguanidines; Modification of the Benzopyran Ring

Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KA TP) Openers. 6. Effect of Modifications at C6 of Benzopyranyl Cyanoguanidines

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators

Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KATP) Openers. 5. Identification of 4-(N-Aryl)-Substituted Benzopyran Derivatives with High Selectivity

Ruthenium Red Improves Postischemic Contractile Function in Isolated Rat Hearts

Cardioselective anti-ischemic ATP-sensitive potassium channel openers

Preconditioning in rat hearts is independent of mitochondrial F1F0 ATPase inhibition

Reduction of ischemic damage in isolated rat hearts by the potassium channel opener, RP 52891

In vitro effects of capsaicin: antiarrhythmic and antiischemic activity

Pharmacologic profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs

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