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Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Journal of medicinal chemistry, 2008-07, Vol.51 (14), p.4239-4252

2008

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Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor

Drug metabolism and disposition, 2003-11, Vol.31 (11), p.1352-1360

2003

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Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3175-3179

2006

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Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5671-5676

2007

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Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor

Drug metabolism and disposition, 2001-06, Vol.29 (6), p.813

2001

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Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1780-1783

2006

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Identification of epoxide- and quinone-derived bromobenzene adducts to protein sulfur nucleophiles

Chemical research in toxicology, 1991-05, Vol.4 (3), p.349-359

1991

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Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective Iks-blocking class III antiarrhythmic agents

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1165-1168

2003

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In vitro and in vivo studies on the metabolism of tirofiban

Drug metabolism and disposition, 1999-11, Vol.27 (11), p.1360

1999

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Rizatriptan, a Novel 5-HT1B/1D Agonist for Migraine: Single- and Multiple-Dose Tolerability and Pharmacokinetics in Healthy Subjects

Journal of clinical pharmacology, 2000-01, Vol.40 (1), p.74-83

2000

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The potential for CYP2D6 inhibition screening using a novel scintillation proximity assay-based approach

Journal of biomolecular screening, 2001-08, Vol.6 (4), p.225-231

2001

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In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s

Drug metabolism and disposition, 1997-10, Vol.25 (10), p.1191

1997

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Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs

Drug metabolism and disposition, 1998-05, Vol.26 (5), p.388

1998

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Synthesis of mercapturic acid derivatives of putative toxic metabolites of bromobenzene

Journal of organic chemistry, 1990-04, Vol.55 (9), p.2736-2742

1990

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Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2 S )-4-(2,5-Difluorophenyl)- N -[(3 R ,4 S )-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)- N -methyl-2-phenyl-2,5-dihydro-1 H -pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Journal of medicinal chemistry, 2008-07, Vol.51 (14), p.4239-4252

2008

Volltextzugriff (PDF)

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I Ks-blocking class III antiarrhythmic agents

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1165-1168

2003

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Kinesin spindle protein (KSP) inhibitors. Part 4: 1 Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (12), p.3175-3179

2006

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Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective IKs-Blocking Class III Antiarrhythmic Agents’

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (15), p.2611

2003

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Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I(Ks)-blocking class III antiarrhythmic agents

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1165-1168

2003

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Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective I Ks-Blocking Class III Antiarrhythmic Agents’ : [Bioorg. Med. Chem. Lett. 13 (2003) 1165]

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (15), p.2611-2611

2003

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Identification of Covalent Adducts to Protein Sulfur Nucleophiles by Alkaline Permethylation

Analytical biochemistry, 1993-02, Vol.208 (2), p.288-295

1993

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Rizatriptan, a Novel 5-HTlB/lD Agonist for Migraine: Single- and Multiple-Dose Tolerability and Pharmacokinetics in Healthy Subjects

Journal of clinical pharmacology, 2000-01, Vol.40 (1), p.74-83

2000

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Rizatriptan, a Novel 5‐HT 1B/1D Agonist for Migraine: Single‐ and Multiple‐Dose Tolerability and Pharmacokinetics in Healthy Subjects

Journal of clinical pharmacology, 2000-01, Vol.40 (1), p.74-83

2000

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Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP

Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP

Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor

Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Identification of epoxide- and quinone-derived bromobenzene adducts to protein sulfur nucleophiles

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective Iks-blocking class III antiarrhythmic agents

In vitro and in vivo studies on the metabolism of tirofiban

Rizatriptan, a Novel 5-HT1B/1D Agonist for Migraine: Single- and Multiple-Dose Tolerability and Pharmacokinetics in Healthy Subjects

The potential for CYP2D6 inhibition screening using a novel scintillation proximity assay-based approach

In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s

Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs

Synthesis of mercapturic acid derivatives of putative toxic metabolites of bromobenzene

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2 S )-4-(2,5-Difluorophenyl)- N -[(3 R ,4 S )-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)- N -methyl-2-phenyl-2,5-dihydro-1 H -pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I Ks-blocking class III antiarrhythmic agents

Kinesin spindle protein (KSP) inhibitors. Part 4: 1 Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP

Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective IKs-Blocking Class III Antiarrhythmic Agents’

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I(Ks)-blocking class III antiarrhythmic agents

Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective I Ks-Blocking Class III Antiarrhythmic Agents’ : [Bioorg. Med. Chem. Lett. 13 (2003) 1165]

Identification of Covalent Adducts to Protein Sulfur Nucleophiles by Alkaline Permethylation

Rizatriptan, a Novel 5-HTlB/lD Agonist for Migraine: Single- and Multiple-Dose Tolerability and Pharmacokinetics in Healthy Subjects

Rizatriptan, a Novel 5‐HT 1B/1D Agonist for Migraine: Single‐ and Multiple‐Dose Tolerability and Pharmacokinetics in Healthy Subjects

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

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