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Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats

Toxicological sciences, 2021-06, Vol.181 (2), p.148-159

2021

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Diagnosis of drug-induced renal tubular toxicity using global gene expression profiles

Journal of translational medicine, 2007-10, Vol.5 (1), p.47-47, Article 47

2007

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Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide

Carcinogenesis (New York), 2000-09, Vol.21 (9), p.1661-1669

2000

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Computer program for the analysis of mutational spectra: application to p53 mutations

Carcinogenesis (New York), 1994-10, Vol.15 (10), p.2281-2285

1994

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Suppression of spontaneous and hydrogen peroxide-induced mutagenesis by the antioxidant ascorbate in mismatch repair-deficient human colon cancer cells

Carcinogenesis (New York), 2001-10, Vol.22 (10), p.1709-1713

2001

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Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice

Cancer research (Chicago, Ill.), 1996-10, Vol.56 (20), p.4654-4661

1996

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Extent of CpG methylation is not proportional to the in vivo spontaneous mutation frequency at transgenic loci in Big Blue™ rodents

Mutation research, 2001-05, Vol.476 (1), p.1-11

2001

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Statistical test for the comparison of samples from mutational spectra

Journal of molecular biology, 1987-04, Vol.194 (3), p.391-396

1987

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Cytotoxic and mutagenic response of mismatch repair-defective human cancer cells exposed to a food-associated heterocyclic amine

Carcinogenesis (New York), 1999-03, Vol.20 (3), p.391-394

1999

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Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests

Environmental and molecular mutagenesis, 2002, Vol.40 (1), p.1-17

2002

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Relative sensitivity of the endogenous hprt gene and lacl transgene in ENU-treated big blue™ B6C3F1 mice

Environmental and molecular mutagenesis, 1995, Vol.26 (1), p.9-15

1995

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In vitro mutational spectrum of aflatoxin B1 in the human hypoxanthine guanine phosphoribosyltransferase gene

Cancer research (Chicago, Ill.), 1994-08, Vol.54 (16), p.4436-4441

1994

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In Vivo Mutations in Human Blood Cells: Biomarkers for Molecular Epidemiology

Environmental Health Perspectives; (United States), 1993-03, Vol.99, p.135-141

1993

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Comparison of motility and membrane integrity to assess rat sperm viability

Reproductive toxicology (Elmsford, N.Y.), 1998-03, Vol.12 (2), p.105-114

1998

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Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines

Mutation research, 1999-06, Vol.427 (2), p.67-78

1999

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Detection of DNA adducts using a quantitative long PCR technique and the fluorogenic 5′ nuclease assay (TaqMan ®)

Mutation research, 2001-12, Vol.484 (1), p.3-18

2001

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In vivo transgenic mutation assays

Environmental and molecular mutagenesis, 2000, Vol.35 (3), p.253-259

2000

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A low volume, high-throughput forward mutation assay in Salmonella typhimurium based on fluorouracil resistance

Mutation research, 2005-10, Vol.578 (1), p.210-224

2005

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Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay

Biochemical and biophysical research communications, 1978-09, Vol.84 (2), p.411-416

1978

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A novel assay for allelic discrimination that combines the fluorogenic 5′ nuclease polymerase chain reaction (TaqMan®) and mismatch amplification mutation assay

Mutation research, 1999-11, Vol.430 (1), p.1-12

1999

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Specificity of mutations induced by the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine in colon cancer cell lines defective in mismatch repair

Cancer research (Chicago, Ill.), 2000-09, Vol.60 (17), p.4921-4925

2000

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Analysis of Mutations Occurring at the Human hprt Locus

Journal of molecular biology, 1993-05, Vol.231 (1), p.41-57

1993

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Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells

Cancer research (Chicago, Ill.), 1992-04, Vol.52 (7), p.2008-2011

1992

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Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats

A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function

Diagnosis of drug-induced renal tubular toxicity using global gene expression profiles

Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide

Computer program for the analysis of mutational spectra: application to p53 mutations

Suppression of spontaneous and hydrogen peroxide-induced mutagenesis by the antioxidant ascorbate in mismatch repair-deficient human colon cancer cells

Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice

Extent of CpG methylation is not proportional to the in vivo spontaneous mutation frequency at transgenic loci in Big Blue™ rodents

Statistical test for the comparison of samples from mutational spectra

Cytotoxic and mutagenic response of mismatch repair-defective human cancer cells exposed to a food-associated heterocyclic amine

Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests

Relative sensitivity of the endogenous hprt gene and lacl transgene in ENU-treated big blue™ B6C3F1 mice

In vitro mutational spectrum of aflatoxin B1 in the human hypoxanthine guanine phosphoribosyltransferase gene

In Vivo Mutations in Human Blood Cells: Biomarkers for Molecular Epidemiology

Comparison of motility and membrane integrity to assess rat sperm viability

Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines

Detection of DNA adducts using a quantitative long PCR technique and the fluorogenic 5′ nuclease assay (TaqMan ®)

In vivo transgenic mutation assays

A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function : The predictive safety testing consortium

A low volume, high-throughput forward mutation assay in Salmonella typhimurium based on fluorouracil resistance

Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay

A novel assay for allelic discrimination that combines the fluorogenic 5′ nuclease polymerase chain reaction (TaqMan®) and mismatch amplification mutation assay

Specificity of mutations induced by the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine in colon cancer cell lines defective in mismatch repair

Analysis of Mutations Occurring at the Human hprt Locus

Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells

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