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The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

Science (American Association for the Advancement of Science), 1993-06, Vol.260 (5116), p.1953-1955

1993

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Cell, 1992-08, Vol.70 (3), p.431-442

1992

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Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

Molecular and Cellular Biology, 1993-12, Vol.13 (12), p.7677-7688

1993

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Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

Molecular and Cellular Biology, 1992-03, Vol.12 (3), p.981-990

1992

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The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

The Journal of biological chemistry, 1996-08, Vol.271 (35), p.20997-21000

1996

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Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

Molecular and Cellular Biology, 1994-08, Vol.14 (8), p.5192-5201

1994

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The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake

Proceedings of the National Academy of Sciences - PNAS, 1995-10, Vol.92 (22), p.10247-10251

1995

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Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK)

Development (Cambridge), 2001-05, Vol.128 (9), p.1559-1572

2001

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Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation

The EMBO journal, 1992-09, Vol.11 (9), p.3469-3479

1992

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Nck Associates with the SH2 Domain-Docking Protein IRS-1 in Insulin- Stimulated Cells

Proceedings of the National Academy of Sciences - PNAS, 1993-12, Vol.90 (24), p.11713-11717

1993

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The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors

Molecular and Cellular Biology, 1992-12, Vol.12 (12), p.5824-5833

1992

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The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

The EMBO journal, 1993-05, Vol.12 (5), p.1929-1936

1993

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Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

Cell, 1991-04, Vol.65 (1), p.83-90

1991

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Activation of Ras by receptor tyrosine kinases

Journal of the American Society of Nephrology, 1994-12, Vol.5 (6), p.1288-1299

1994

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Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

The Journal of biological chemistry, 1998-11, Vol.273 (46), p.30497-30508

1998

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Structural Basis for Discrimination of 3-Phosphoinositides by Pleckstrin Homology Domains

Molecular cell, 2000-08, Vol.6 (2), p.373-384

2000

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Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin

Molecular and Cellular Biology, 1995-03, Vol.15 (3), p.1778-1785

1995

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

The EMBO journal, 1998-09, Vol.17 (18), p.5374-5387

1998

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Advanced glycosylation endproduct-specific receptors on human and rat T-lymphocytes mediate synthesis of interferon γ : role in tissue remodeling

The Journal of experimental medicine, 1993-12, Vol.178 (6), p.2165-2172

1993

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Activation of p38 Mitogen-Activated Protein Kinase by Sodium Salicylate Leads to Inhibition of Tumor Necrosis Factor-Induced IκBα Phosphorylation and Degradation

Molecular and Cellular Biology, 1998-01, Vol.18 (1), p.78-84

1998

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Sodium Salicylate Induces Apoptosis via p38 Mitogen-Activated Protein Kinase but Inhibits Tumor Necrosis Factor-Induced c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase Activation

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (7), p.2869-2873

1997

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NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

The EMBO journal, 1997-03, Vol.16 (6), p.1279-1290

1997

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Genetic Analysis of the Myotubularin Family of Phosphatases in Caenorhabditis elegans

The Journal of biological chemistry, 2003-09, Vol.278 (36), p.34380-34386

2003

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Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A2 receptor antibody-positive membranous nephropathy

Clinical kidney journal, 2012-04, Vol.5 (2), p.162-165

2012

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Nck-Interacting Ste20 Kinase Couples Eph Receptors to c-Jun N-Terminal Kinase and Integrin Activation

Molecular and Cellular Biology, 2000-03, Vol.20 (5), p.1537-1545

2000

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The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake

Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK)

Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation

Nck Associates with the SH2 Domain-Docking Protein IRS-1 in Insulin- Stimulated Cells

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors

The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

Activation of Ras by receptor tyrosine kinases

Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

Structural Basis for Discrimination of 3-Phosphoinositides by Pleckstrin Homology Domains

Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

Advanced glycosylation endproduct-specific receptors on human and rat T-lymphocytes mediate synthesis of interferon γ : role in tissue remodeling

Activation of p38 Mitogen-Activated Protein Kinase by Sodium Salicylate Leads to Inhibition of Tumor Necrosis Factor-Induced IκBα Phosphorylation and Degradation

Sodium Salicylate Induces Apoptosis via p38 Mitogen-Activated Protein Kinase but Inhibits Tumor Necrosis Factor-Induced c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase Activation

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

Genetic Analysis of the Myotubularin Family of Phosphatases in Caenorhabditis elegans

Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A2 receptor antibody-positive membranous nephropathy

Nck-Interacting Ste20 Kinase Couples Eph Receptors to c-Jun N-Terminal Kinase and Integrin Activation

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