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Integrin β3 directly inhibits the Gα13-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosis

Nature communications, 2023-08, Vol.14 (1), p.4966-4966, Article 4966

2023

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Gα13 Mediates Transendothelial Migration of Neutrophils by Promoting Integrin-Dependent Motility without Affecting Directionality

The Journal of immunology (1950), 2021-12, Vol.207 (12), p.3038-3049

2021

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Carboxypeptidase M Is a Positive Allosteric Modulator of the Kinin B1 Receptor

The Journal of biological chemistry, 2013-11, Vol.288 (46), p.33226-33240

2013

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Ervin G. Erdös, MD, (October 16, 1922-November 17, 2019)

Hypertension (Dallas, Tex. 1979), 2020-06, Vol.75 (6), p.1360-1362

2020

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Targeting Gα13-integrin interaction ameliorates systemic inflammation

Nature communications, 2021-05, Vol.12 (1), p.1-14, Article 3185

2021

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Angiotensin I–Converting Enzyme Inhibitors Are Allosteric Enhancers of Kinin B1 and B2 Receptor Function

Hypertension (Dallas, Tex. 1979), 2010-02, Vol.55 (2), p.214-220

2010

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Endothelial Nitric-oxide Synthase Activation Generates an Inducible Nitric-oxide Synthase-like Output of Nitric Oxide in Inflamed Endothelium

The Journal of biological chemistry, 2013-02, Vol.288 (6), p.4174-4193

2013

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Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice

PloS one, 2009-01, Vol.4 (1), p.e4226-e4226

2009

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ICAM-1–activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration

Blood, 2012-08, Vol.120 (9), p.1942-1952

2012

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Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition

Molecular biology of the cell, 2012-04, Vol.23 (7), p.1388-1398

2012

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Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells

BMC medicine, 2012-01, Vol.10 (1), p.3-3, Article 3

2012

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Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling

Cellular signalling, 2015-01, Vol.27 (1), p.90-103

2015

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PR65A phosphorylation regulates PP2A complex signaling

PloS one, 2014-01, Vol.9 (1), p.e85000-e85000

2014

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Cross-talk between Carboxypeptidase M and the Kinin B1 Receptor Mediates a New Mode of G Protein-coupled Receptor Signaling

The Journal of biological chemistry, 2011-05, Vol.286 (21), p.18547-18561

2011

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Novel Mechanism of Endothelial Nitric Oxide Synthase Activation Mediated by Caveolae Internalization in Endothelial Cells

Circulation research, 2006-10, Vol.99 (8), p.870-877

2006

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High-loading Gα 13 -binding EXE peptide nanoparticles prevent thrombosis and protect mice from cardiac ischemia/reperfusion injury

Science translational medicine, 2020-07, Vol.12 (552)

2020

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Carboxypeptidase M and Kinin B1 Receptors Interact to Facilitate Efficient B1 Signaling from B2 Agonists

The Journal of biological chemistry, 2008-03, Vol.283 (12), p.7994-8004

2008

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A Phosphoinositide 3-Kinase-AKT-Nitric Oxide-cGMP Signaling Pathway in Stimulating Platelet Secretion and Aggregation

The Journal of biological chemistry, 2006-06, Vol.281 (24), p.16333-16339

2006

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UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy

Cellular signalling, 2015-05, Vol.27 (5), p.908-922

2015

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Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studies

Peptides, 2004-03, Vol.25 (3), p.521-525

2004

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Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output

Biological chemistry, 2013-03, Vol.394 (3), p.335-345

2013

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Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity

The Journal of biological chemistry, 2015-05, Vol.290 (19), p.12058-12067

2015

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Caveolin-1 Regulates Store-Operated Ca2+ Influx by Binding of Its Scaffolding Domain to Transient Receptor Potential Channel-1 in Endothelial Cells

Molecular pharmacology, 2006-10, Vol.70 (4), p.1174-1183

2006

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Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator

International immunopharmacology, 2007-12, Vol.7 (14), p.1888-1899

2007

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Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors

Cellular signalling, 2012-08, Vol.24 (8), p.1619-1631

2012

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Integrin β3 directly inhibits the Gα13-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosis

Gα13 Mediates Transendothelial Migration of Neutrophils by Promoting Integrin-Dependent Motility without Affecting Directionality

Carboxypeptidase M Is a Positive Allosteric Modulator of the Kinin B1 Receptor

Ervin G. Erdös, MD, (October 16, 1922-November 17, 2019)

Targeting Gα13-integrin interaction ameliorates systemic inflammation

Angiotensin I–Converting Enzyme Inhibitors Are Allosteric Enhancers of Kinin B1 and B2 Receptor Function

Endothelial Nitric-oxide Synthase Activation Generates an Inducible Nitric-oxide Synthase-like Output of Nitric Oxide in Inflamed Endothelium

Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice

ICAM-1–activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration

Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition

Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells

Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling

PR65A phosphorylation regulates PP2A complex signaling

Cross-talk between Carboxypeptidase M and the Kinin B1 Receptor Mediates a New Mode of G Protein-coupled Receptor Signaling

Novel Mechanism of Endothelial Nitric Oxide Synthase Activation Mediated by Caveolae Internalization in Endothelial Cells

High-loading Gα 13 -binding EXE peptide nanoparticles prevent thrombosis and protect mice from cardiac ischemia/reperfusion injury

Carboxypeptidase M and Kinin B1 Receptors Interact to Facilitate Efficient B1 Signaling from B2 Agonists

A Phosphoinositide 3-Kinase-AKT-Nitric Oxide-cGMP Signaling Pathway in Stimulating Platelet Secretion and Aggregation

UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy

Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studies

Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output

Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity

Caveolin-1 Regulates Store-Operated Ca2+ Influx by Binding of Its Scaffolding Domain to Transient Receptor Potential Channel-1 in Endothelial Cells

Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator

Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors

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