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γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

Nature reviews. Neuroscience, 2002-04, Vol.3 (4), p.281-290

2002

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The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

The Journal of biological chemistry, 2003-03, Vol.278 (10), p.7751-7754

2003

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Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice

Cell, 2005-03, Vol.120 (5), p.701-713

2005

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Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats

Annals of the New York Academy of Sciences, 2005-11, Vol.1056 (1), p.261-278

2005

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Evidence That Synaptically Released beta -Amyloid Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice

The Journal of neuroscience, 2002-11, Vol.22 (22), p.9785-9793

2002

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Nuclear Inclusions in Glutamine Repeat Disorders: Are They Pernicious, Coincidental, or Beneficial?

Cell, 1998-10, Vol.95 (1), p.1-4

Sisodia, Sangram S

1998

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Mutant genes in familial Alzheimer's disease and transgenic models

Annual review of neuroscience, 1998-01, Vol.21 (1), p.479-505

1998

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Spatial segregation of gamma-secretase and substrates in distinct membrane domains

The Journal of biological chemistry, 2005-07, Vol.280 (27), p.25892-25900

2005

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Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces

Neuron (Cambridge, Mass.), 2001-12, Vol.32 (5), p.911-926

2001

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Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited

The Journal of neuroscience, 2005-03, Vol.25 (9), p.2386-2395

2005

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Evidence That the “NF” Motif in Transmembrane Domain 4 of Presenilin 1 Is Critical for Binding with PEN-2

The Journal of biological chemistry, 2005-12, Vol.280 (51), p.41953-41966

2005

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Assessment of antidiabetic potential of Cinnamomum tamala leaves extract in streptozotocin induced diabetic rats

Indian journal of pharmacology, 2011-09, Vol.43 (5), p.582-585

2011

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β-Amyloid Precursor Protein Cleavage by a Membrane-Bound Protease

Proceedings of the National Academy of Sciences - PNAS, 1992-07, Vol.89 (13), p.6075-6079

Sisodia, Sangram S.

1992

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Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

Neuron (Cambridge, Mass.), 1997-10, Vol.19 (4), p.939-945

1997

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Presenilin-dependent “γ-Secretase” Processing of Deleted in Colorectal Cancer (DCC)

The Journal of biological chemistry, 2003-08, Vol.278 (33), p.30425-30428

2003

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Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system

The Journal of neuroscience, 1993-07, Vol.13 (7), p.3136-3142

1993

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Phospholipase D1 Corrects Impaired βAPP Trafficking and Neurite Outgrowth in Familial Alzheimer's Disease-Linked Presenilin-1 Mutant Neurons

Proceedings of the National Academy of Sciences - PNAS, 2006-02, Vol.103 (6), p.1936-1940

2006

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ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models

Annual review of genetics, 1998-01, Vol.32 (1), p.461-493

1998

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Hepatoprotective activity of Eugenia jambolana Lam. in carbon tetrachloride treated rats

Indian journal of pharmacology, 2009-01, Vol.41 (1), p.23-27

2009

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Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

Nature Medicine, 1998-04, Vol.4 (4), p.447-451

1998

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Presenilin-1 Uses Phospholipase D1 as a Negative Regulator of β-Amyloid Formation

Proceedings of the National Academy of Sciences - PNAS, 2006-02, Vol.103 (6), p.1941-1946

2006

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A Sequence within the First Transmembrane Domain of PEN-2 Is Critical for PEN-2-mediated Endoproteolysis of Presenilin 1

The Journal of biological chemistry, 2005-01, Vol.280 (3), p.1992-2001

2005

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Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

The Journal of biological chemistry, 2001-11, Vol.276 (47), p.43756-43760

2001

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ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

Neuron (Cambridge, Mass.), 1997-02, Vol.18 (2), p.327-338

1997

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Effects of PS1 deficiency on membrane protein trafficking in neurons

Neuron (Cambridge, Mass.), 1998-11, Vol.21 (5), p.1213-1221

1998

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γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice

Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats

Evidence That Synaptically Released beta -Amyloid Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice

Nuclear Inclusions in Glutamine Repeat Disorders: Are They Pernicious, Coincidental, or Beneficial?

Mutant genes in familial Alzheimer's disease and transgenic models

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces

Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited

Evidence That the “NF” Motif in Transmembrane Domain 4 of Presenilin 1 Is Critical for Binding with PEN-2

Assessment of antidiabetic potential of Cinnamomum tamala leaves extract in streptozotocin induced diabetic rats

β-Amyloid Precursor Protein Cleavage by a Membrane-Bound Protease

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

Presenilin-dependent “γ-Secretase” Processing of Deleted in Colorectal Cancer (DCC)

Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system

Phospholipase D1 Corrects Impaired βAPP Trafficking and Neurite Outgrowth in Familial Alzheimer's Disease-Linked Presenilin-1 Mutant Neurons

ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models

Hepatoprotective activity of Eugenia jambolana Lam. in carbon tetrachloride treated rats

Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

Presenilin-1 Uses Phospholipase D1 as a Negative Regulator of β-Amyloid Formation

A Sequence within the First Transmembrane Domain of PEN-2 Is Critical for PEN-2-mediated Endoproteolysis of Presenilin 1

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

Effects of PS1 deficiency on membrane protein trafficking in neurons

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