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The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

Redox biology, 2021-10, Vol.46, p.102109-102109, Article 102109

Siraki, Arno G.

2021

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Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants

Chemico-biological interactions, 2021-08, Vol.345, p.109574-109574, Article 109574

2021

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Target identification of small molecules: an overview of the current applications in drug discovery

BMC biotechnology, 2023-10, Vol.23 (1), p.1-44, Article 44

2023

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Heating of consumer cannabis oils can lead to free radical initiated degradation, causing CBD and THC depletion

Free radical biology & medicine, 2022-11, Vol.192, p.77-83

2022

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Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action

British journal of pharmacology, 2019-12, Vol.176 (24), p.4599-4608

2019

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Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Health

Critical reviews in toxicology, 2005-08, Vol.35 (7), p.609-662

2005

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Comprehensive in vitro characterization of PD-L1 small molecule inhibitors

Scientific reports, 2019-08, Vol.9 (1), p.12392-19, Article 12392

2019

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Neutrophil Myeloperoxidase-Mediated N‑Demethylation of Quetiapine Leads to N‑Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite

Chemical research in toxicology, 2022-06, Vol.35 (6), p.1001-1010

2022

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The Interaction of Myeloperoxidase with the Industrial Contaminant 6‑PPD: A Potential Pathway for Reactive Metabolites

Chemical research in toxicology, 2024-10, Vol.37 (10), p.1738-1746

2024

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Introduction to the special issue from the 10th meeting of the Canadian Oxidative Stress Consortium

Chemico-biological interactions, 2019-10, Vol.312, p.108800-108800, Article 108800

2019

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Application of electron paramagnetic resonance spectroscopy for determining the relative nanoenvironment fluidity of polymeric micelles

European biophysics journal, 2024-05, Vol.53 (4), p.171-181

2024

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Comparing the oxidative functions of neutrophil myeloperoxidase and cytochrome P450 enzymes in drug metabolism

Chemico-biological interactions, 2024-04, Vol.392, p.110942-110942, Article 110942

2024

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Caution for the routine use of phenol red – It is more than just a pH indicator

Chemico-biological interactions, 2019-09, Vol.310, p.108739-108739, Article 108739

2019

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Characterization of Mechanisms of Glutathione Conjugation with Halobenzoquinones in Solution and HepG2 Cells

Environmental science & technology, 2018-03, Vol.52 (5), p.2898-2908

2018

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Effect of Plasma-Activated Water Bubbles on Fusarium graminearum , Deoxynivalenol, and Germination of Naturally Infected Barley during Steeping

Toxins, 2023-02, Vol.15 (2), p.124

2023

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Post-Trapping Derivatization of Radical-Derived EPR-Silent Adducts: Application to Free Radical Detection by HPLC/UV in Chemical, Biochemical, and Biological Systems and Comparison with EPR Spectroscopy

Analytical chemistry (Washington), 2012-08, Vol.84 (15), p.6739-6746

2012

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Eosinophil peroxidase oxidizes isoniazid to form the active metabolite against M. tuberculosis, isoniazid-NAD

Chemico-biological interactions, 2019-05, Vol.305, p.48-53

2019

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2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy

Scientific reports, 2018-02, Vol.8 (1), p.2780-15, Article 2780

2018

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Machine learning in toxicological sciences: opportunities for assessing drug toxicity

Frontiers in drug discovery, 2024-02, Vol.4

2024

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Scavenging of Free-Radical Metabolites of Aniline Xenobiotics and Drugs by Amino Acid Derivatives: Toxicological Implications of Radical-Transfer Reactions

Chemical research in toxicology, 2013-12, Vol.26 (12), p.1872-1883

2013

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Current status and future prospects of toxicogenomics in drug discovery

Drug discovery today, 2014-05, Vol.19 (5), p.562-578

2014

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β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models

International journal of molecular sciences, 2021-09, Vol.22 (19), p.10550

2021

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Reactive Oxygen Species Mediate Therapeutic Ultrasound-Induced, Mitogen-Activated Protein Kinase Activation in C28/I2 Chondrocytes

Ultrasound in medicine & biology, 2018-10, Vol.44 (10), p.2105-2114

2018

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Role of Reactive Oxygen Species during Low-Intensity Pulsed Ultrasound Application in MC-3 T3 E1 Pre-osteoblast Cell Culture

Ultrasound in medicine & biology, 2017-11, Vol.43 (11), p.2699-2712

2017

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Phenylbutazone Oxidation via Cu,Zn-SOD Peroxidase Activity: An EPR Study

Chemical research in toxicology, 2015-07, Vol.28 (7), p.1476-1483

2015

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The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants

Target identification of small molecules: an overview of the current applications in drug discovery

Heating of consumer cannabis oils can lead to free radical initiated degradation, causing CBD and THC depletion

Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action

Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Health

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors

Neutrophil Myeloperoxidase-Mediated N‑Demethylation of Quetiapine Leads to N‑Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite

The Interaction of Myeloperoxidase with the Industrial Contaminant 6‑PPD: A Potential Pathway for Reactive Metabolites

Introduction to the special issue from the 10th meeting of the Canadian Oxidative Stress Consortium

Application of electron paramagnetic resonance spectroscopy for determining the relative nanoenvironment fluidity of polymeric micelles

Comparing the oxidative functions of neutrophil myeloperoxidase and cytochrome P450 enzymes in drug metabolism

Caution for the routine use of phenol red – It is more than just a pH indicator

Characterization of Mechanisms of Glutathione Conjugation with Halobenzoquinones in Solution and HepG2 Cells

Effect of Plasma-Activated Water Bubbles on Fusarium graminearum , Deoxynivalenol, and Germination of Naturally Infected Barley during Steeping

Post-Trapping Derivatization of Radical-Derived EPR-Silent Adducts: Application to Free Radical Detection by HPLC/UV in Chemical, Biochemical, and Biological Systems and Comparison with EPR Spectroscopy

Eosinophil peroxidase oxidizes isoniazid to form the active metabolite against M. tuberculosis, isoniazid-NAD

2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy

Machine learning in toxicological sciences: opportunities for assessing drug toxicity

Scavenging of Free-Radical Metabolites of Aniline Xenobiotics and Drugs by Amino Acid Derivatives: Toxicological Implications of Radical-Transfer Reactions

Current status and future prospects of toxicogenomics in drug discovery

β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models

Reactive Oxygen Species Mediate Therapeutic Ultrasound-Induced, Mitogen-Activated Protein Kinase Activation in C28/I2 Chondrocytes

Role of Reactive Oxygen Species during Low-Intensity Pulsed Ultrasound Application in MC-3 T3 E1 Pre-osteoblast Cell Culture

Phenylbutazone Oxidation via Cu,Zn-SOD Peroxidase Activity: An EPR Study

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