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Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo

Oncogenesis (New York, NY), 2015-02, Vol.4 (2), p.e137-e137

2015

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Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides

Organic & biomolecular chemistry, 2017-06, Vol.15 (22), p.4882-4896

2017

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Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

Chemical science (Cambridge), 2014-01, Vol.5 (12), p.4794-4799

2014

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Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum

European journal of medicinal chemistry, 2017-02, Vol.127, p.22-40

2017

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Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration

RSC chemical biology, 2022-04, Vol.3 (4), p.468-485

2022

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Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)

MedChemComm, 2017-02, Vol.8 (2), p.465-470

2017

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Identification of potential hit compounds for Dengue virus NS2B/NS3 protease inhibitors by combining virtual screening and binding free energy calculations

Tropical biomedicine, 2013-09, Vol.30 (3), p.388-408

2013

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Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.482-491

2018

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Design, Synthesis, and Structure−Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-yl)ethylamino]pyridazine Derivatives as Acetylcholinesterase Inhibitors

Journal of medicinal chemistry, 2001-08, Vol.44 (17), p.2707-2718

2001

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Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1545-1555

2016

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Epigenetic Drug Discovery

1, 2019

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PARADOCKS – a framework for molecular docking

Journal of cheminformatics, 2011-04, Vol.3 (Suppl 1), p.P35-P35, Article P35

2011

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Application of biasing-potential replica exchange simulations for loop modeling and refinement of proteins in explicit solvent

Journal of cheminformatics, 2011-04, Vol.3 (Suppl 1), p.P33-P33, Article P33

2011

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Translational molecular imaging and drug development in Parkinson's disease

Molecular neurodegeneration, 2023-02, Vol.18 (1), p.11-11, Article 11

2023

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Receptor-based 3D QSAR analysis of estrogen receptor ligands--merging the accuracy of receptor-based alignments with the computational efficiency of ligand-based methods

Journal of computer-aided molecular design, 2000-08, Vol.14 (6), p.559-572

Sippl, W

2000

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Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni

Journal of molecular biology, 2014-10, Vol.426 (20), p.3442-3453

2014

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Development of biologically active compounds by combining 3D QSAR and structure-based design methods

Journal of computer-aided molecular design, 2002-11, Vol.16 (11), p.825-830

2002

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Docking and virtual screening of novel inhibitors for mono-ADP-ribosylating toxins

Journal of cheminformatics, 2011-04, Vol.3 (Suppl 1), p.P38-P38, Article P38

2011

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Target-Based Approach to Inhibitors of Histone Arginine Methyltransferases

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2319-2325

2007

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Binding affinity prediction of novel estrogen receptor ligands using receptor-based 3-D QSAR methods

Bioorganic & medicinal chemistry, 2002-12, Vol.10 (12), p.3741-3755

Sippl, Wolfgang

2002

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Model of a specific human histamine H3 receptor (hH3R) binding pocket suitable for virtual drug design

Inflammation research, 2005-04, Vol.54 Suppl 1 (S1), p.S50-S51

2005

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Degradation of tropoelastin by matrix metalloproteinases - cleavage site specificities and release of matrikines

The FEBS journal, 2010-04, Vol.277 (8), p.1939-1956

2010

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Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimidesElectronic supplementary information (ESI) available: Additional photochromic data, docking scores, additional docking poses and NMR spectra. See DOI: 10.1039/c7ob00976c

2017-06

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Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni

Journal of biomolecular screening, 2015-01, Vol.20 (1), p.112-121

2015

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Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)The authors declare no competing interests.Electronic supplementary information (ESI) available: All the experimental details, NMR spectra, MS and HPLC analysis results. See DOI: 10.1039/c6md00647g

2017-02

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Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides

Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum

Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration

Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)

Identification of potential hit compounds for Dengue virus NS2B/NS3 protease inhibitors by combining virtual screening and binding free energy calculations

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)

Design, Synthesis, and Structure−Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-yl)ethylamino]pyridazine Derivatives as Acetylcholinesterase Inhibitors

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

Epigenetic Drug Discovery

PARADOCKS – a framework for molecular docking

Application of biasing-potential replica exchange simulations for loop modeling and refinement of proteins in explicit solvent

Translational molecular imaging and drug development in Parkinson's disease

Receptor-based 3D QSAR analysis of estrogen receptor ligands--merging the accuracy of receptor-based alignments with the computational efficiency of ligand-based methods

Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni

Development of biologically active compounds by combining 3D QSAR and structure-based design methods

Docking and virtual screening of novel inhibitors for mono-ADP-ribosylating toxins

Target-Based Approach to Inhibitors of Histone Arginine Methyltransferases

Binding affinity prediction of novel estrogen receptor ligands using receptor-based 3-D QSAR methods

Model of a specific human histamine H3 receptor (hH3R) binding pocket suitable for virtual drug design

Degradation of tropoelastin by matrix metalloproteinases - cleavage site specificities and release of matrikines

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimidesElectronic supplementary information (ESI) available: Additional photochromic data, docking scores, additional docking poses and NMR spectra. See DOI: 10.1039/c7ob00976c

Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni

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